Structural basis of death domain signaling in the p75 neurotrophin receptor.
Singapore, Singapore. In Elife, Jan 2016
Here we report structures of complexes formed by the DD of p75 neurotrophin receptor (p75(NTR)) with RhoGDI, for activation of the RhoA pathway, with caspase recruitment domain (CARD) of RIP2 kinase, for activation of the NF-kB pathway, and with itself, revealing how DD dimerization controls access of intracellular effectors to the receptor.
Ubiquitination in Rho signaling.
Xiamen, China. In Curr Top Med Chem, 2011
Importantly, regulators for Rho GTP-GDP cycling such as RhoGDI and Rho-GEF ECT2 were also found to be modulated by the ubiquitin pathway.
Glioma pathophysiology: insights emerging from proteomics.
Edinburgh, United Kingdom. In Brain Pathol, 2010
Importantly 10 of the 99 proteins found differentially expressed in glioma [PHB, Hsp20, serum albumin, epidermal growth factor receptor (EGFR), EA-15, RhoGDI, APOA1, GFAP, HSP70, PDIA3] were identified in multiple publications.
RhoGDI signaling provides targets for cancer therapy.
Charlottesville, United States. In Eur J Cancer, 2010
Using examples of RhoGDI-mediated signaling and expression patterns in endothelial cells as well as pancreatic, breast, and bladder cancer, the multitude of potential cancer therapeutic targets presented by a better understanding of their function is illustrated.