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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Rho GTPase activating protein 1

RhoGAP, DLC1, Cdc42GAP
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: Rhodopsin, GAP, RhoA, Actin, Cdc42
Papers using RhoGAP antibodies
The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1
Supplier
Lo Su Hao et al., In The Journal of Cell Biology, 2003
... The full-length and truncated fragments of DLC-1 were subcloned in frame into mammalian expression vector pEGFP-C2 (CLONTECH Laboratories, Inc.), yeast expression ...
ERK5 promotes Src-induced podosome formation by limiting Rho activation
Supplier
Martin G. Steven et al., In The Journal of Cell Biology, 1999
... blebbistatin were obtained from EMD; MEK inhibitors U0126 and PD 98,059 were obtained from Sigma-Aldrich; anti-RhoGAP7/DLC-1 was obtained from BD Biosciences; and gelatin–Oregon green 488 ...
Papers on RhoGAP
A combined binary interaction and phenotypic map of C. elegans cell polarity proteins.
New
Impact
Boxem et al., Utrecht, Netherlands. In Nat Cell Biol, Feb 2016
We demonstrate the predictive capabilities of the network by showing that the physical interaction between the RhoGAP PAC-1 and PAR-6 is required for radial polarization of the C. elegans embryo.
SYD-1 Promotes Multiple Developmental Steps Leading to Neuronal Connectivity.
New
Quinn et al., Milwaukee, United States. In Mol Neurobiol, Jan 2016
In this review, we focus on SYD-1, a RhoGAP-like protein that has been implicated in each step of axonal development.
Inhibitory effects of Arhgap6 on cervical carcinoma cells.
Review
New
Yin et al., Shanghai, China. In Tumour Biol, Jan 2016
UNASSIGNED: Ras homology GTPase activation protein 6 (Arhgap6), as a member of the rhoGAP family of proteins, performs vital functions on the regulation of actin polymerization at the plasma membrane during several cellular processes.
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
New
Impact
Yap et al., Brisbane, Australia. In Nat Cell Biol, Oct 2015
ROCK1 protects junctional RhoA by phosphorylating Rnd3 to prevent the cortical recruitment of the Rho suppressor, p190B RhoGAP.
Rho regulation: DLC proteins in space and time.
Review
New
Olayioye et al., Stuttgart, Germany. In Cell Signal, Aug 2015
In this review we will focus on the Deleted in Liver Cancer (DLC) family of RhoGAP proteins and summarize the evidence gathered over the past years revealing their different subcellular localizations that might account for isoform-specific functions.
An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity.
New
Impact
Nance et al., New York City, United States. In Nat Cell Biol, Jun 2015
In Caenorhabditis elegans, contacts polarize early embryonic cells by recruiting the RhoGAP PAC-1 to the adjacent cortex, inducing PAR protein asymmetry.
Dystrophin induced cognitive impairment: mechanisms, models and therapeutic strategies.
Review
New
Wijekoon et al., Chandīgarh, India. In Ann Neurosci, Apr 2015
TGF-β, RhoGAP and CAM mediated signalling molecules are the chief cause of mortalities due to respiratory and cardiac involvement but remain underevaluated targets for cognitive impairment in DMD/BMD.
Clinicopathological Significance of DLC-1 Expression in Cancer: a Meta-Analysis.
Luo et al., Changsha, China. In Asian Pac J Cancer Prev, 2014
BACKGROUND: Recent reports have shown that DLC-1 is widely expressed in normal tissues and is down- regulated in a wide range of human tumors, suggesting it may act as a tumor suppressor gene.
Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.
Grinstein et al., Toronto, Canada. In Nat Commun, 2014
Through a screen of 62 RhoGAP-family members, we demonstrate that ARHGAP12, ARHGAP25 and SH3BP1 are responsible for GTPase inactivation.
Enhanced p122RhoGAP/DLC-1 Expression Can Be a Cause of Coronary Spasm.
Okumura et al., Hirosaki, Japan. In Plos One, 2014
We also reported that p122Rho GTPase-activating protein/deleted in liver cancer-1 (p122RhoGAP/DLC-1) protein, which was discovered as a PLC-δ1 stimulator, was upregulated in CSA patients.
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.
Wu et al., In J Clin Invest, 2014
Structural analyses revealed that the RhoGAP domain of Myo9b contains a unique patch that specifically recognizes RhoA.
Molecular physiology of the tensin brotherhood of integrin adaptor proteins.
Review
Haynie, Tampa, United States. In Proteins, 2014
Involved in cell attachment and migration, cytoskeleton reorganization, signal transduction and other processes relevant to cancer research, tensins have recently been linked to functional properties of deleted in liver cancer 1 (DLC1) and a mitogen-activated protein kinases (MAPK), to cell migration in breast cancer, and to metastasis suppression in the kidney.
Deleted in liver cancer-1 (DLC1): an emerging metastasis suppressor gene.
Review
Goodison et al., Bethesda, United States. In Mol Diagn Ther, 2014
Evidence implicating the protein deleted in liver cancer-1 (DLC1), a Rho GTPase activator, in metastasis has accumulated to a point where DLC1 may be considered as a metastasis suppressor gene.
Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells.
GeneRIF
Lowy et al., Bethesda, United States. In Cancer Res, 2012
complex formation between the DLC1 START domain and CAV-1 contributes to DLC1 tumor suppression via a RhoGAP-independent mechanism, and suggest that DLC1 inactivation probably contributes to cancer progression.
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.
Impact
Yap et al., Brisbane, Australia. In Nat Cell Biol, 2012
Centralspindlin also inhibits the junctional localization of p190 B RhoGAP, which can inactivate Rho.
Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.
GeneRIF
Zhu et al., Hong Kong, Hong Kong. In J Biol Chem, 2012
The tumor suppressor DLC1 utilizes a novel binding site for tensin2 PTB domain interaction
DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity.
GeneRIF
Zimonjic et al., Bethesda, United States. In Mol Cell Biol, 2012
a new mechanism through which DLC1 exerts its strong oncosuppressive function by positively influencing adherens junctions stability
Secretory pathway-dependent localization of the Saccharomyces cerevisiae Rho GTPase-activating protein Rgd1p at growth sites.
GeneRIF
Doignon et al., Bordeaux, France. In Eukaryot Cell, 2012
Rgd1p colocalizes with a subset of the post-golgi marker Sec2p and is transported to the bud tip.
Downregulation of DLEC1 in sinonasal inverted papilloma and squamous cell carcinoma.
GeneRIF
Tsai et al., Taiwan. In J Otolaryngol Head Neck Surg, 2012
Repression of DLEC1 in squamous cell carcinoma tissues is associated with promoter hypermethylation. DLEC1 is downregulated in sinonasal squamous cell carcinoma and inverted papilloma and has a distinct mechanism.
Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans.
Impact
Hengartner et al., Zürich, Switzerland. In Nat Cell Biol, 2011
Multicellular animals rapidly clear dying cells from their bodies.
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