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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Rho-related BTB domain containing 1

RHOBTB1, RHOBTB
The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] (from NCBI)
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Top mentioned proteins: Rhodopsin, Cul3, Ubiquitin, Arht1, Early Growth Response Protein 2
Papers on RHOBTB1
Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.
Rivero et al., Köln, Germany. In Exp Cell Res, 2008
Two of the three RhoBTB proteins, RhoBTB1 and RhoBTB2, have been proposed as tumor suppressors and might function as adaptors of Cul3-dependent ubiquitin ligase complexes.
Rho GTPases of the RhoBTB subfamily and tumorigenesis.
Review
Rivero et al., Köln, Germany. In Acta Pharmacol Sin, 2008
In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3.
Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer.
GeneRIF
Shimizu et al., Okayama, Japan. In J Cancer Res Clin Oncol, 2006
Frequent allelic loss and decreased expression of RHOBTB1 suggested that this gene has a role in tumorigenesis of a subset of HNSCC (Head-Neck Squamous Cell Carcinoma).
Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection.
Spaink et al., Leiden, Netherlands. In Genomics, 2005
The analysis shows the presence of 32 zebrafish Rho genes representing one or more homologs of the human RHOA, RND3, RHOF, RHOG, RHOH, RHOJ, RHOU, RHOV, CDC42, RAC1, RAC2, RAC3, RND1, RHOBTB1, RHOBTB2, RHOBTB3, and RHOT1 genes.
DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways.
Hamaguchi et al., United States. In J Mol Biol, 2005
The tumor suppressor DBC2 belongs to a previously uncharacterized gene family, RHOBTB (Bric-a-brac, Tramtrack, Broad-complex).
High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor.
Zacksenhaus et al., Toronto, Canada. In Gene Expr Patterns, 2004
Deleted in Breast Cancer-2, Dbc2, identified as a candidate tumor suppressor gene for breast cancer and other human malignancies, is a member of a novel gene family encoding putative small GTPases designated as Rhobtb.
Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.
Rivero et al., Köln, Germany. In Gene, 2002
RHOBTB1 and RHOBTB2 have a similar exon-intron organization and are closely related to the single gene encoding the RhoBTB orthologs of two insect species.
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