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Ras homolog gene family, member B

RhoB, H-6
member of the ras gene superfamily; GTP-binding proteins [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoA, Actin, RhoC, CAN
Papers on RhoB
The bisphosphonate zoledronic acid regulates key angiogenesis-related genes in primary human gingival fibroblasts.
Seymour et al., Dunedin, New Zealand. In Arch Oral Biol, Mar 2016
Statistically significant increases in gene expression were found for RHOB, VEGFA, CD55 and BMP2 (p≤0.05) in response to 30μM zoledronic acid.
RASSF1A suppresses the invasion and metastatic potential of human non-small cell lung cancer cells by inhibiting YAP activation through the GEF-H1/RhoB pathway.
Zalcman et al., Caen, France. In Cancer Res, Feb 2016
Mechanistic investigations revealed that RASSF1A blocked tumor growth by stimulating cofilin/PP2A-mediated dephosphorylation of the guanine nucleotide exchange factor GEF-H1, thereby stimulating its ability to activate the anti-metastatic small GTPase RhoB.
The Role of RhoA, RhoB and RhoC GTPases in Cell Morphology, Proliferation and Migration in Human Cytomegalovirus (HCMV) Infected Glioblastoma Cells.
Sourvinos et al., Irákleion, Greece. In Cell Physiol Biochem, Feb 2016
METHODS: RhoA, RhoB and RhoC were individually depleted in U373MG glioblastoma cells as well as U373MG cells stably expressing the HCMV IE1 protein (named U373MG-IE1 cells) shRNA lentivirus vectors.
Romidepsin and azacitidine synergize in their epigenetic modulatory effects to induce apoptosis in CTCL.
Dummer et al., Zürich, Switzerland. In Clin Cancer Res, Jan 2016
We identified genes that were selectively induced by the combination treatment, such the tumor suppressor gene RhoB that is linked to enhanced histone acetylation at its promoter region in parallel with pronounced expression of p21.
Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells.
Rupasinghe et al., Truro, Canada. In Chem Biol Interact, Jan 2016
This correlated with the downregulation of G-protein (RHOA, RHOB) and RAS (ATF2, HRAS, KRAS, NRAS) pathway signaling.
Dual inhibition of histone deacetylases and phosphoinositide 3-kinases: effects on Burkitt lymphoma cell growth and migration.
Klumb et al., Rio de Janeiro, Brazil. In J Leukoc Biol, Dec 2015
Moreover, histone deacetylase inhibitor/PI3K inhibitor cotreatment suppressed Burkitt lymphoma cell migration and decreased cell polarization, Akt and ERK1/2 phosphorylation, and leads to RhoB induction.
RhoB regulates the function of macrophages in the hypoxia-induced inflammatory response.
Lu et al., Shanghai, China. In Cell Mol Immunol, Oct 2015
The small GTPase RhoB is usually rapidly induced by a variety of stimuli and has been described as an important regulator of cytoskeletal organization and vesicle and membrane receptor trafficking.
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease.
Lutz et al., Göttingen, Germany. In Front Pharmacol, 2014
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC.
Time course of the response to ACTH in pig: biological and transcriptomic study.
Mormède et al., France. In Bmc Genomics, 2014
In particular, DDIT4, DUSP1, FKBP5, IL7R, NFKBIA, PER1, RGS2 and RHOB were shown to be connected to each other by the glucocorticoid receptor NR3C1.
Postnatal neuronal apoptosis in the cerebral cortex: physiological and pathophysiological mechanisms.
Tucker et al., Heidelberg, Germany. In Neuroscience, 2014
The underlying reason for this apoptotic wave remains unclear, but molecular mechanisms are starting to be elucidated that account for its mechanism, including a role for insulin-like growth factor I (IGF-1) and the Rho GTPases RhoA and RhoB.
Toward understanding RhoGTPase specificity: structure, function and local activation.
Hordijk et al., Amsterdam, Netherlands. In Small Gtpases, 2013
RhoA, RhoB, and RhoC are highly homologous GTPases that, however, succeed in generating specific intracellular responses.
Rho GTPase isoforms in cell motility: Don't fret, we have FRET.
Hodgson et al., United States. In Cell Adh Migr, 2013
Clearly, additional efforts are still required to produce biosensor systems capable of detecting other isoforms of Rho GTPases including RhoB, Rac2/3, RhoG, etc. Through such efforts, we will uncover the isoform-specific roles of these near-identical proteins in living cells, clearly an important area of the Rho GTPase biology that is not yet fully appreciated.
Physiological roles of Rho and Rho effectors in mammals.
Narumiya et al., Kyoto, Japan. In Eur J Cell Biol, 2013
Of several Rho GTPases in mammals, the best characterized is the Rho subfamily including ubiquitously expressed RhoA and its homologs RhoB and RhoC.
Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia.
Wilkins et al., London, United Kingdom. In Circ Res, 2012
RhoB mediates adaptational changes to acute hypoxia in the vasculature, but its continual activation by chronic hypoxia can accentuate vascular remodeling to promote development of pulmonary hypertension.
Immunohistochemical expression of Rho GTPases in ameloblastomas.
Crema et al., Florianópolis, Brazil. In J Oral Pathol Med, 2012
RhoB may have a key role in ameloblastoma neoplastic epithelial cell phenotype determination, as well as in variant and subtype determination; different results of RhoB are observed in follicular and plexiform ameloblastomas.
Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB.
Gopala et al., Thiruvananthapuram, India. In Eur J Pharm Sci, 2012
AE downregulated mRNA expression and promoter/gelatinolytic activity of the RhoB expression at gene and protein level.
Altered apoptotic responses in neurons lacking RhoB GTPase.
Morris et al., Glasgow, United Kingdom. In Eur J Neurosci, 2011
These data directly implicate neuronal RhoB in caspase 3 activation and the initial stages of programmed cell death.
miR-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells.
Bi et al., Chengdu, China. In Febs Lett, 2011
Data show that expression of miR-21 in HEK293 and several colorectal cancer cell lines is inversely correlated with ras homolog gene family, member B (RhoB) expression.
Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.
Ahn et al., Boulder, United States. In Science, 2008
The process requires endosome trafficking, is associated with multivesicular bodies, and is regulated by Wnt5a through the small guanosine triphosphatases Rab4 and RhoB.
Actin' up: RhoB in cancer and apoptosis.
Prendergast, United States. In Nat Rev Cancer, 2001
RhoB is dispensable for normal cell physiology but it has a suppressor or negative modifier function in stress-associated processes including cancer.
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