G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.
Coleraine, United Kingdom. In Acta Diabetol, Feb 2016
In addition, GPR43 also couples to the Gαq subunit augmenting intracellular Ca(2+) and activating phospholipase C. GPR55 is specific for cannabinoid endogenous agonists (endocannabinoids) and non-cannabinoid fatty acids, which couples to Gα12/13 and Gαq proteins, leading to enhancing intracellular Ca(2+), extracellular signal-regulated kinase 1/2 (ERK) phosphorylation and Rho kinase.
Rho kinase inhibitors for glaucoma treatment - Review.
São Paulo, Brazil. In Arq Bras Oftalmol, Dec 2015
Currently, an increasing number of researches involve Rho kinase inhibitors, which are a new pharmacological class of hypotensive agents specifically targeting the diseased trabecular outflow pathway.
PPAR-ϒ pathway to vascular dysfunction.
Milwaukee, United States. In Cell Metab, 2012
(2012) shows that loss of PPAR-ϒ repression of the Rho kinase pathway leads to altered vascular function via a smooth-muscle-dependent pathway that is independent of NO and oxidant stress.