G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis.
Coleraine, United Kingdom. In Acta Diabetol, Feb 2016
In addition, GPR43 also couples to the Gαq subunit augmenting intracellular Ca(2+) and activating phospholipase C. GPR55 is specific for cannabinoid endogenous agonists (endocannabinoids) and non-cannabinoid fatty acids, which couples to Gα12/13 and Gαq proteins, leading to enhancing intracellular Ca(2+), extracellular signal-regulated kinase 1/2 (ERK) phosphorylation and Rho kinase.
Rho kinase inhibitors for glaucoma treatment - Review.
São Paulo, Brazil. In Arq Bras Oftalmol, Dec 2015
Currently, an increasing number of researches involve Rho kinase inhibitors, which are a new pharmacological class of hypotensive agents specifically targeting the diseased trabecular outflow pathway.
Progress in corneal wound healing.
Los Angeles, United States. In Prog Retin Eye Res, Nov 2015
Successful surgical ways of replacing the diseased endothelium have been clinically tested, and new approaches to accelerate endothelial healing and suppress endothelial-mesenchymal transformation have been proposed including Rho kinase (ROCK) inhibitor eye drops and gene therapy to activate TGF-β inhibitor SMAD7.
PPAR-ϒ pathway to vascular dysfunction.
Milwaukee, United States. In Cell Metab, 2012
(2012) shows that loss of PPAR-ϒ repression of the Rho kinase pathway leads to altered vascular function via a smooth-muscle-dependent pathway that is independent of NO and oxidant stress.