GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
Ras homolog enriched in brain like 1
RhebL1, Rheb2, Rheb-like protein
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Top mentioned proteins:
mTOR, Rheb, ACID, mTORC1, CAN
Papers on
RhebL1
Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.
New
Tokyo, Japan. In J Biol Chem, Feb 2015
Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) in mammalian cells, are unique members of the Ras superfamily and play central roles in regulating protein synthesis and cell growth by activating mTOR.
Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.
Cardiff, United Kingdom. In Mol Psychiatry, 2013
an intergenic polymorphism on chromosome 12 located between RHEBL1 and DHH.
DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia.
Bologna, Italy. In Oncotarget, 2013
We identified a new fusion transcript in the CBFA2T3-GLIS2-positive patients, involving Desert Hedgehog (DHH), a member of Hedgehog family, and Ras Homologue Enrich in Brain Like 1 (RHEBL1), a gene coding for a small GTPase of the Ras family.
Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function.
Review
Indianapolis, United States. In Ann N Y Acad Sci, 2012
This review provides information about the general field of CB transplantation and about studies from the author's laboratory that focus on regulation of HSCs and HPCs by CD26/DPPIV, SDF-1/CXCL12, the Rheb2-mTOR pathway, SIRT1, DEK, cyclin-dependent kinase inhibitors, and cytokines/growth factors.
Effects of RhebL1 silencing on the mTOR pathway.
GeneRIF
Camarillo, United States. In Mol Biol Rep, 2012
RhebL1 may be impacting the mTOR pathway in a different manner than Rheb1.
Ex vivo rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice.
Indianapolis, United States. In Blood Cells Mol Dis, 2011
Our laboratory previously demonstrated that Rheb2 overexpression significantly impaired the repopulating ability of HSC.
Rheb1 is required for mTORC1 and myelination in postnatal brain development.
Chengdu, China. In Dev Cell, 2011
The roles of mTor activators, Rheb1 and Rheb2, have not been established in vivo.
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.
Chapel Hill, United States. In Oncogene, 2010
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer and are attractive targets for anti-cancer drug discovery.
Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation.
Indianapolis, United States. In Blood, 2009
We examined the role of the novel ras gene Rheb2, an activator of the mTOR kinase, in colony-forming ability, survival, and repopulation of immature mouse hematopoietic cells.
Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition.
Cardiff, United Kingdom. In Cell Signal, 2009
Finally, we show that activation of mTORC1 by both Rheb and RhebL1 is impaired by FKBP38.
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
Los Angeles, United States. In J Biol Chem, 2009
Both Rheb1 and Rheb2 activate mTORC1.
The monomeric G proteins AGS1 and Rhes selectively influence Galphai-dependent signaling to modulate N-type (CaV2.2) calcium channels.
Logan, United States. In Am J Physiol Cell Physiol, 2008
Transfection with HRas, KRas2, Rap1A-G12V, Rap2B, Rheb2, or Gem failed to duplicate the effects of AGS1 and Rhes on Ca(V)2.2.
Activation of the mTOR signaling pathway in renal clear cell carcinoma.
Philadelphia, United States. In J Urol, 2007
Mutational analysis of Rheb and RhebL1 was performed on DNA from phospho-mTOR/phospho-S6 positive clear cell renal cell carcinoma.
Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas.
Philadelphia, United States. In Mod Pathol, 2006
We hypothesized that this S6 hyperphosphorylation could reflect mutational activation of Rheb or Rheb-like protein (RhebL1), Ras family members which directly activate mTOR.
Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B.
GeneRIF
Shanghai, China. In Mol Biol Rep, 2005
RHEBL1 is a positive regulator of NF-kappa B-mediated gene transcription.
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
GeneRIF
Dundee, United Kingdom. In Febs Lett, 2005
Data show that Rheb like-1 protein (RhebL1) rescues mTOR signaling during nutrient withdrawal, and identify critical residues in Rheb and RhebL1 which are required for their efficient activation of mTOR signaling.
