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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Rh blood group, D antigen

RhD, Rh30
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, RHCE, POLYMERASE, ACID, HAD
Papers on RhD
Intron 4 of the RH Gene in Han Chinese, Tibetan, and Mongol Populations.
New
Zhou et al., Guangzhou, China. In Genet Test Mol Biomarkers, Jan 2016
AIMS: This study aimed to compare the intron 4 sequence of the RHD and RHCE genes from Han Chinese, Tibetans, and Mongols, and explore its polymorphisms.
[Molecular mechanism of 101A>G and 845G>A mutations of RHD gene responsible for a weak RhD].
New
Li et al., Shenyang, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Oct 2015
METHODS: Regular serological assaying and indirect antiglobulin testing (IAT) were performed to characterize the RhD blood group.
Impact of a confirmatory RhD test on the correct serologic typing of blood donors.
New
da Silva Malta et al., Belo Horizonte, Brazil. In Rev Bras Hematol Hemoter, Sep 2015
BACKGROUND: The RHD gene is highly polymorphic, which results in a large number of RhD variant phenotypes.
[Standardization of the quantitative flow cytometric test with anti-D antibodies for fetomaternal hemorrhage in RhD negative women].
New
Brojer et al., In Ginekol Pol, Jul 2015
One of the quantitative methods of FMH analysis is based on flow cytometry (FACS) which makes use of monoclonal antibodies to RhD antigen (anti-D test).
Worse Health Status and Higher Incidence of Health Disorders in Rhesus Negative Subjects.
Dammann et al., Praha, Czech Republic. In Plos One, 2014
Rhesus-positive and Rhesus-negative persons differ in the presence-absence of highly immunogenic RhD protein on the erythrocyte membrane.
Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition.
Dominici et al., Roma, Italy. In J Exp Clin Cancer Res, 2014
METHODS: RH4 and RH30 alveolar RMS (ARMS) cell lines were treated with crizotinib and then assessed by using proliferation, viability, migration and colony formation assays.
IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors.
Heyman et al., Uppsala, Sweden. In Plos One, 2014
This is used clinically in Rhesus prophylaxis, where administration of IgG anti-RhD prevents RhD-negative women from becoming immunized against RhD-positive fetal erythrocytes aquired transplacentally.
Non-invasive prenatal testing using cell-free fetal DNA in maternal circulation.
Review
Zhao et al., In Clin Chim Acta, 2014
In recent years, technical advances in the molecular analysis of fetal DNA (e.g., digital PCR and massively parallel sequencing (MPS)) has enabled the successful implementation of noninvasive testing into clinical practice, such as fetal sex assessment, RhD genotyping, and fetal chromosomal aneuploidy detection.With the ability to decipher the entire fetal genome from maternal plasma DNA, we foresee that an increased number of non-invasive prenatal tests will be available for detecting many single-gene disorders in the near future.
Clinical and laboratory update on the DEL variant.
Review
Prachayasittikul et al., Bangkok, Thailand. In Lab Med, 2013
Serological assays for the RhD blood group are based on detection of the RhD antigen on human red blood cells using a specific anti-D antibody.
Congenital factor XI deficiency: an update.
Review
Salomon et al., Milano, Italy. In Semin Thromb Hemost, 2013
Inhibitors to FXI were described in patients with null-allele mutations, following exposure to plasma, FXI concentrates, or anti-RhD immunoglobulin.
Tracking fetal development through molecular analysis of maternal biofluids.
Review
Bianchi et al., Boston, United States. In Biochim Biophys Acta, 2012
Over the last 15 years, significant advances in noninvasive prenatal diagnosis (NIPD) via cell-free fetal (cff) nucleic acids in maternal plasma have resulted in the ability to determine fetal sex, RhD genotype, and aneuploidy.
Characterization of novel RHD alleles: relationship between phenotype, genotype, and trimeric architecture.
GeneRIF
Bailly et al., Marseille, France. In Transfusion, 2012
Characterization of novel RHD alleles.
RHD alleles in Brazilian blood donors with weak D or D-negative phenotypes.
GeneRIF
Bordin et al., São Paulo, Brazil. In Transfus Med, 2012
The RHD genotyping proved to be a necessary tool to characterise RHD alleles in donors phenotyped as D- or weak D to increase the transfusion safety in highly racial mixed population.
A novel laboratory technique demonstrating the influences of RHD zygosity and the RhCcEe phenotype on erythrocyte D antigen expression.
GeneRIF
Ware et al., Houston, United States. In Am J Hematol, 2012
RHD homozygotes had nearly twice as many D antigen sites as hemizygotes. Expression of c or E antigens was associated with increased RBC D antigen expression, but presence of C or e antigens reduced expression.
Anti-D investigations in individuals expressing weak D Type 1 or weak D Type 2: allo- or autoantibodies?
GeneRIF
Le Pennec et al., Paris, France. In Transfusion, 2011
Anti-D investigations in individuals expressing weak D Type 1 or weak D Type 2
Distribution of weak D types in the Croatian population.
GeneRIF
Jukic et al., In Transfus Med, 2011
Distribution of weak D types in the Croatian population.
Molecular genetics and clinical applications for RH.
Review
Flegel, Bethesda, United States. In Transfus Apher Sci, 2011
The RHD and RHCE genes are strongly homologous.
The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast.
Impact
Chérif-Zahar et al., Brussels, Belgium. In Nat Genet, 2000
The Rhesus blood-group antigens are defined by a complex association of membrane polypeptides that includes the non-glycosylated Rh proteins (RhD and RhCE) and the RHag glycoprotein, which is strictly required for cell surface expression of these antigens.
Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma.
Impact
Wainscoat et al., Hong Kong, Hong Kong. In N Engl J Med, 1999
BACKGROUND: The ability to determine fetal RhD Status noninvasively is useful in the treatment of RhD-sensitized pregnant women whose partners are heterozygous for the RhD gene.
Molecular genetic basis of the human Rhesus blood group system.
Impact
Le Van Kim et al., Paris, France. In Nat Genet, 1993
The Rhesus (RH) blood group locus is composed of two related structural genes, D and CcEe, that encode red cell membrane proteins carrying the D, Cc and Ee antigens.
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