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Rhesus blood group-associated C glycoprotein

Rhcg, Rhcg1
plasma membrane glycoportein; mouse homolog is an ammonium transporter; may be involved in ammonium secretion into bile fluid [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rhbg, CD45, ACID, Rh2, ATPase
Papers on Rhcg
Differential modulation of ammonia excretion, Rhesus glycoproteins and ion-regulation in common carp (Cyprinus carpio) following individual and combined exposure to waterborne copper and ammonia.
Boeck et al., Antwerp, Belgium. In Aquat Toxicol, Jan 2016
Expression of Rhcg (Rhcg-a and Rhcg-b) mRNA was upregulated during HEA, thereby facilitated ammonia efflux out of gills.
Mechanisms of ammonia and ammonium transport by rhesus-associated glycoproteins.
Nakhoul et al., New Orleans, United States. In Am J Physiol Cell Physiol, Jan 2016
In this study we characterized ammonia and ammonium (NH3/NH4 (+)) transport by the rhesus-associated (Rh) glycoproteins RhAG, Rhbg, and Rhcg expressed in Xenopus oocytes.
The water channel aquaporin-1a1 facilitates movement of CO2 and ammonia in zebrafish (Danio rerio) larvae.
Perry et al., Ottawa, Canada. In J Exp Biol, Dec 2015
The possibility that AQP1a1 and the rhesus glycoprotein Rhcg1, which also serves as a dual CO2 and ammonia channel, act in concert to facilitate CO2 and ammonia excretion was explored.
Cortisol affects metabolic and ionoregulatory responses to a different extent depending on feeding ration in common carp, Cyprinus carpio.
De Boeck et al., Kuala Terengganu, Malaysia. In Comp Biochem Physiol A Mol Integr Physiol, Nov 2015
At 3%-BM, this did not increase plasma ammonia, reflecting improved excretion efficiency concomitant with upregulation of Rhesus glycoprotein Rhcg-1 in gill.
Expression of ammonia transporters Rhbg and Rhcg in mouse skeletal muscle and the effect of 6-week training on these proteins.
Takemasa et al., Tsukuba, Japan. In Physiol Rep, Oct 2015
The purposes of our study were to examine (1) Rh B glycoprotein (Rhbg) and Rh C glycoprotein (Rhcg) expressions in mouse skeletal muscle; and (2) the effect of 6-week training on Rhbg and Rhcg expressions.
Mechanism of NH4(+) Recruitment and NH3 Transport in Rh Proteins.
Bernèche et al., Basel, Switzerland. In Structure, Sep 2015
Using molecular and quantum mechanical calculations, we show that a crystallographically identified site in the RhCG pore actually recruits NH4(+), which is found in higher concentration and binds with higher affinity than NH3, increasing the efficiency of the transport mechanism.
Physiological and molecular responses of the goldfish (Carassius auratus) kidney to metabolic acidosis, and potential mechanisms of renal ammonia transport.
Wood et al., Vancouver, Canada. In J Exp Biol, Jul 2015
There was also a 3.5-fold increase in the mRNA expression of renal Rhcg-b (Rhcg1) mRNA.
Effect of dietary protein restriction on renal ammonia metabolism.
Weiner et al., China. In Am J Physiol Renal Physiol, Jul 2015
Rhcg deletion did not alter ammonia excretion in response to dietary protein restriction.
Evaluating the microRNA-target gene regulatory network in renal cell carcinomas, identification for potential biomarkers and critical pathways.
Sheng et al., Shanghai, China. In Int J Clin Exp Med, 2014
PPI nodes of high degrees, such as RHCG, RALYL, SLC4A1, UMOD and CA9, were obtained.
Ammonia transport in the kidney by Rhesus glycoproteins.
Verlander et al., Gainesville, United States. In Am J Physiol Renal Physiol, 2014
Subsequently, the nonerythroid Rh glycoproteins, Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg), were cloned and identified as ammonia transporters.
Characteristics of mammalian Rh glycoproteins (SLC42 transporters) and their role in acid-base transport.
Lee Hamm et al., New Orleans, United States. In Mol Aspects Med, 2013
The mammalian Rh glycoproteins belong to the solute transporter family SLC42 and include RhAG, present in red blood cells, and two non-erythroid members RhBG and RhCG that are expressed in various tissues, including kidney, liver, skin and the GI tract.
Effect of hypokalemia on renal expression of the ammonia transporter family members, Rh B Glycoprotein and Rh C Glycoprotein, in the rat kidney.
Weiner et al., Seoul, South Korea. In Am J Physiol Renal Physiol, 2011
Increased plasma membrane Rhcg expression in response to hypokalemia in the rat, particularly in the outer medullary collecting duct, likely contributes to the increased ammonia excretion and thereby to the development of metabolic alkalosis.
The rhesus protein RhCG: a new perspective in ammonium transport and distal urinary acidification.
Houillier et al., Zürich, Switzerland. In Kidney Int, 2011
In rodents, RhBG and RhCG are expressed in the collecting duct, whereas in humans only RhCG was detected.
Molecular physiology of the Rh ammonia transport proteins.
Verlander et al., Gainesville, United States. In Curr Opin Nephrol Hypertens, 2010
RECENT FINDINGS: The Rh glycoproteins, RhAG/Rhag, RhBG/Rhbg and RhCG/Rhcg, transport ammonia in the form of molecular NH3, although there is some evidence suggesting the possibility of NH4 transport.
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.
Weiner et al., Gainesville, United States. In Am J Physiol Renal Physiol, 2010
Rhcg expression in intercalated cells is necessary for the normal renal response to metabolic acidosis, contributing to both basal and acidosis-stimulated ammonia excretion. Adaptations in Rhbg expression occur in response to acid-loading.
Expression of ammonia transporter family members, Rh B glycoprotein and Rh C glycoprotein, in the developing rat kidney.
Weiner et al., Seoul, South Korea. In Am J Physiol Renal Physiol, 2010
Expression of Rhbg and Rhcg parallels intercalated cell development and that immature Rhbg and Rhcg expression at birth contributes to incomplete ammonia excretion capacity.
Function of human Rh based on structure of RhCG at 2.1 A.
Stroud et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2010
X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport.
The Rh protein family: gene evolution, membrane biology, and disease association.
Ye et al., New York City, United States. In Cell Mol Life Sci, 2010
The Rh factor and Rh-associated glycoprotein (RhAG), with epithelial cousins RhBG and RhCG, form four subgroups conferring upon vertebrates a genealogical commonality.
Functional reconstitution into liposomes of purified human RhCG ammonia channel.
Ripoche et al., Paris, France. In Plos One, 2009
major finding of this study is that RhCG protein is active as an NH(3) channel and that this function does not require any protein partner
A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility.
Marini et al., Brussels, Belgium. In Nature, 2008
a critical role for Rhcg in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract
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