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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulator of G-protein signaling 20

RGSZ1, RGS20, RET-RGS1
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: RGS, GAIP, RGS17, GAP, CAN
Papers on RGSZ1
Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis.
Wong et al., Hong Kong, Hong Kong. In Cancer Lett, 2013
Coexpression of RGS19, but not RGS20, in NIH3T3 cells effectively suppressed neoplastic transformation and tumorigenesis induced by the oncogenic Ras(GV) mutant.
Estradiol induces partial desensitization of serotonin 1A receptor signaling in the paraventricular nucleus of the hypothalamus and alters expression and interaction of RGSZ1 and Gαz.
Muma et al., Lawrence, United States. In Neuropharmacology, 2012
The effects of two once daily injections of 10 μg/kg/day EB on Gαz and RGSZ1 proteins were examined as components of the 5-HT(1A) receptor signaling system, which mediates the release of oxytocin and adrenocorticotropic hormone.
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.
Gelernter et al., New Haven, United States. In Behav Brain Funct, 2011
BACKGROUND: RGS17 and RGS20 encode two members of the regulator of G-protein signaling RGS-Rz subfamily.
Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling.
Jockers et al., Paris, France. In Embo J, 2010
The molecular organization of the ternary MT₁/G(i)/RGS20 complex was monitored in its basal and activated state by bioluminescence resonance energy transfer between probes inserted at multiple sites of the complex.
RGS19 enhances cell proliferation through its C-terminal PDZ motif.
Wong et al., Hong Kong, Hong Kong. In Cell Signal, 2010
This growth promoting effect was not shared by other RGS proteins including RGS4, RGS10 and RGS20.
Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling.
Garzón et al., Madrid, Spain. In Plos One, 2009
In neurons, histidine triad nucleotide binding protein 1 (HINT1) connects the regulators of G protein signaling RGSZ1 and RGSZ2 to the C terminus of the MOR.
Probing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse.
Vardi et al., Philadelphia, United States. In J Comp Neurol, 2008
We obtained positive transcripts for G(o) interactors: regulators of G-protein signaling (RGS), Ret-RGS1 (a variant of RGS20), RGS16, RGS7, purkinje cell protein 2 (PCP2, also called L7 or GPSM4), synembryn (RIC-8), LGN (GPSM2), RAP1GAP, and Gbeta5; cGMP modulators: guanylyl cyclase (GC) 1alpha1, GC1beta1, phosphodiesterase (PDE) 1C, and PDE9A; and channels: inwardly rectifying potassium channel Kir2.4,
NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.
Garzón et al., Madrid, Spain. In Cell Signal, 2008
In neurons, the C terminus of the Mu-opioid receptor (MOR) binds to the protein kinase C-interacting protein/histidine triad nucleotide binding protein 1 (PKCI/HINT1) which in turn binds the regulator of G-protein signalling RGSZ1/Z2 (RGSZ) protein.
Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.
Iyengar et al., New York City, United States. In Cell Signal, 2008
We have found that activated Galpha(o/i) interact with RGS20, a GTPase activating protein for members of the Galpha(omicron/i) family.
Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.
Miki et al., Japan. In Hypertens Res, 2008
Replication of the findings and possible polygenic interaction was evaluated in five G-protein-related positive genes (GNI2, GNA14, RGS2, RGS19, RGS20) in a large cohort population (total n=9,700, 3,305 hypertensives and 3,827 normotensive controls).
The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis.
Matta et al., Mobile, United States. In Bmc Med Genomics, 2007
In contrast, the metastatic melanomas express higher levels of genes such as MAGE, GPR19, BCL2A1, MMP14, SOX5, BUB1, RGS20, and more.
Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain.
Garzón et al., Madrid, Spain. In Neuropsychopharmacology, 2007
The RGSZ1 and RGSZ2 proteins, members of the RGS-Rz subfamily of GTPase-activating proteins (GAP), are involved in Mu-opioid receptor desensitization.
RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.
GeneRIF
Young et al., Princeton, United States. In Cell Signal, 2007
The major function of PKCI-1 is to modulate mu opioid receptor signaling pathway along with RGSZ1, rather than directly mediating the Galphaz RGSZ1 interaction.
RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling.
Review
Albert et al., London, Canada. In Semin Cell Dev Biol, 2006
The RZ/A family includes RGSZ2/RGS17 (the most recently discovered member of this family), GAIP/RGS19, RGSZ1/RGS20, and the RGSZ1 variant Ret-RGS.
A role for G(z) in pancreatic islet beta-cell biology.
Casey et al., Durham, United States. In J Biol Chem, 2005
Indeed, overexpression of a selective deactivator of G alpha(z), the RGS domain of RGSZ1, blocks the inhibitory effect of PGE1 on glucose-stimulated insulin secretion.
1H, 13C and 15N resonance assignments of human RGSZ1.
GeneRIF
Moy et al., In J Biomol Nmr, 2004
NMR study
Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.
GeneRIF
Young et al., Princeton, United States. In J Biol Chem, 2003
provide new evidence that RGSZ1 interacts not only with Galpha(z,) but also with Galpha(i), as supported by in vitro binding assays and functional studies
The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.
GeneRIF
Casey et al., Durham, United States. In J Biol Chem, 2002
Analysis of in vitro microtubule polymerization/depolymerization showed that binding of RGSZ1 to SCG10 effectively blocked the ability of SCG10 to induce microtubule disassembly
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