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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulator of G-protein signaling 9

RGS9, RGS9-2, RGS9-1, regulator of G-protein signaling 9
This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: RGS, ROD, RGS7, Phosphodiesterase, CAN
Papers on RGS9
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.
Hepler et al., Atlanta, United States. In Mol Pharmacol, Feb 2016
Here, we review and highlight the current knowledge of specific RGS proteins (RGS2, RGS4, RGS7, RGS9-2, and RGS14) that have been clearly demonstrated to serve critical roles in modulating synaptic signaling and plasticity throughout the brain, and we consider their potential as future therapeutic targets.
Retinal Architecture in ​RGS9- and ​R9AP-Associated Retinal Dysfunction (Bradyopsia).
Michaelides et al., London, United Kingdom. In Am J Ophthalmol, Dec 2015
PURPOSE: To characterize photoreceptor structure and mosaic integrity in subjects with ​RGS9- and R9AP-associated retinal dysfunction (bradyopsia) and compare to previous observations in other cone dysfunction disorders such as oligocone trichromacy.
Perinatal Treatments with the Dopamine D2-Receptor Agonist Quinpirole Produces Permanent D2-Receptor Supersensitization: a Model of Schizophrenia.
Brown et al., Johnson City, United States. In Neurochem Res, Dec 2015
However, quinpirole-induced D2-R supersensitivity is associated with cognitive deficits, also a deficit in pre-pulse inhibition and in neurotrophic factors, and low levels of the transcript regulator of G-protein signaling (RGS) RGS9 in brain; and acute reversal of these alterations by the antipsychotic agent olanzapine.
RGS9-2--controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states.
Zachariou et al., Irákleion, Greece. In Proc Natl Acad Sci U S A, Oct 2015
The striatal protein Regulator of G-protein signaling 9-2 (RGS9-2) plays a key modulatory role in opioid, monoamine, and other G-protein-coupled receptor responses.
Evidence for the contribution of genetic variations in regulator of G protein signaling 9 to the genetic susceptibility of heroin dependence.
Zhang et al., Xi'an, China. In Mol Med Report, May 2015
RGS9‑2, a brain‑specific splice variant of the RGS9 gene, is highly expressed in the striatum but lowly expressed in the periaqueductal gray and spinal cord, which mediate various actions of morphine and other opiates.
Speeding rod recovery improves temporal resolution in the retina.
Burns et al., Davis, United States. In Vision Res, May 2015
Here, we have used a transgenic mouse line with faster than normal rod phototransduction deactivation (RGS9-overexpressors) to test whether rod signaling to second-order retinal neurons is rate-limited by phototransduction or by other mechanisms.
Structure and binding of the C-terminal segment of R9AP to lipid monolayers.
Salesse et al., Québec, Canada. In Langmuir, Mar 2015
This is achieved by a protein complex which is presumably anchored to photoreceptor disc membranes by means of the transmembrane C-terminal segment of RGS9-1-Anchor Protein (R9AP).
RGS Protein Regulation of Phototransduction.
Chen, Houston, United States. In Prog Mol Biol Transl Sci, 2014
First identified in yeast and worm and later in other species, the physiological importance of Regulators of G-protein Signaling (RGS) in mammals was first demonstrated at the turn of the century in mouse retinal photoreceptors, in which RGS9 is needed for timely recovery of rod phototransduction.
Retinal cone photoreceptors require phosducin-like protein 1 for G protein complex assembly and signaling.
Willardson et al., Salt Lake City, United States. In Plos One, 2014
G protein β subunits (Gβ) play essential roles in phototransduction as part of G protein βγ (Gβγ) and regulator of G protein signaling 9 (RGS9)-Gβ5 heterodimers.
Comparison between the behavior of different hydrophobic peptides allowing membrane anchoring of proteins.
Salesse et al., Québec, Canada. In Adv Colloid Interface Sci, 2014
The secondary structure content of the C-terminal peptides of retinol dehydrogenase 8, RGS9-1 anchor protein, lecithin retinol acyl transferase, and of the N-terminal peptide of retinol dehydrogenase 11 has been deduced by prediction tools from their primary sequence as well as by using infrared or circular dichroism analyses.
Timing is everything: GTPase regulation in phototransduction.
Wensel et al., Durham, United States. In Invest Ophthalmol Vis Sci, 2013
Soon after, the G protein β isoform Gβ5 was identified as an obligate partner subunit, followed by the discovery or R9AP, a transmembrane protein that anchors the RGS9 GAP complex to the disk membrane, and is essential for the localization, stability, and activity of this complex in vivo.
Pathognomonic (diagnostic) ERGs. A review and update.
Holder et al., Toronto, Canada. In Retina, 2013
PURPOSE: To review three inherited retinal disorders associated with diagnostic or pathognomonic electroretinogram (ERG) abnormalities: cone dystrophy with supernormal rod ERG (KCNV2), enhanced S-cone syndrome (NR2E3), and bradyopsia (RGS9/R9AP).
β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation.
Kim et al., Kwangyang, South Korea. In Mol Cell Biol, 2011
beta-Arrestin2 is required for the inhibition of D3R signaling by RGS9-2.
The involvement of RGS9 in l-3,4-dihydroxyphenylalanine-induced dyskinesias in unilateral 6-OHDA lesion rat model.
Zhu et al., Beijing, China. In Brain Res Bull, 2011
RGS9 expression in striatum may involve in the abnormal involuntary movements induced by l-DOPA therapy
RGS9-2 modulates nociceptive behaviour and opioid-mediated synaptic transmission in the spinal dorsal horn.
Antal et al., Irákleion, Greece. In Neurosci Lett, 2011
RGS9-2 may play a crucial role in opiate-mediated analgesic mechanisms at the level of the spinal cord.
RGS9 knockout causes a short delay in light responses of ON-bipolar cells.
Arshavsky et al., Durham, United States. In Plos One, 2010
RGS9 knockout causes a short delay in light responses of ON-bipolar cells.
Association between regulator of G protein signaling 9-2 and body weight.
Kovoor et al., Dallas, United States. In Plos One, 2010
These studies with humans, rats and mice implicate RGS9-2 as a factor in regulating body weight.
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.
Dryja et al., Boston, United States. In Nature, 2004
five unrelated patients with recessive mutations in the genes encoding either RGS9 or R9AP who report difficulty adapting to sudden changes in luminance levels mediated by cones
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A.
Sigler et al., New Haven, United States. In Nature, 2001
Here we describe the crystal structure at 2.0 A of rod transducin alpha x GDP x AlF4- in complex with the effector molecule PDEgamma and the GTPase-activating protein RGS9.
Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1.
Simon et al., Pasadena, United States. In Nature, 2000
Recent reconstitution experiments indicate that one of these, RGS9-1, may account for much of the Galphat GAP activity in rod outer segments (ROS).
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