Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.
Atlanta, United States. In Mol Pharmacol, Feb 2016
Here, we review and highlight the current knowledge of specific RGS proteins (RGS2, RGS4, RGS7, RGS9-2, and RGS14) that have been clearly demonstrated to serve critical roles in modulating synaptic signaling and plasticity throughout the brain, and we consider their potential as future therapeutic targets.
Speeding rod recovery improves temporal resolution in the retina.
Davis, United States. In Vision Res, May 2015
Here, we have used a transgenic mouse line with faster than normal rod phototransduction deactivation (RGS9-overexpressors) to test whether rod signaling to second-order retinal neurons is rate-limited by phototransduction or by other mechanisms.
RGS Protein Regulation of Phototransduction.
Houston, United States. In Prog Mol Biol Transl Sci, 2014
First identified in yeast and worm and later in other species, the physiological importance of Regulators of G-protein Signaling (RGS) in mammals was first demonstrated at the turn of the century in mouse retinal photoreceptors, in which RGS9 is needed for timely recovery of rod phototransduction.
Timing is everything: GTPase regulation in phototransduction.
Durham, United States. In Invest Ophthalmol Vis Sci, 2013
Soon after, the G protein β isoform Gβ5 was identified as an obligate partner subunit, followed by the discovery or R9AP, a transmembrane protein that anchors the RGS9 GAP complex to the disk membrane, and is essential for the localization, stability, and activity of this complex in vivo.
Pathognomonic (diagnostic) ERGs. A review and update.
Toronto, Canada. In Retina, 2013
PURPOSE: To review three inherited retinal disorders associated with diagnostic or pathognomonic electroretinogram (ERG) abnormalities: cone dystrophy with supernormal rod ERG (KCNV2), enhanced S-cone syndrome (NR2E3), and bradyopsia (RGS9/R9AP).