Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.
Atlanta, United States. In Mol Pharmacol, Feb 2016
Here, we review and highlight the current knowledge of specific RGS proteins (RGS2, RGS4, RGS7, RGS9-2, and RGS14) that have been clearly demonstrated to serve critical roles in modulating synaptic signaling and plasticity throughout the brain, and we consider their potential as future therapeutic targets.
RGS Protein Regulation of Phototransduction.
Houston, United States. In Prog Mol Biol Transl Sci, 2014
The role of RGS in vision has also been established a synapse away in retinal depolarizing bipolar cells (DBCs), where RGS7 and RGS11 work redundantly and in a complex with Gβ5-S as GAPs for Goα in the metabotropic glutamate receptor 6 pathway situated at DBC dendritic tips.
Localized, non-random differences in chromatin accessibility between homologous metaphase chromosomes.
London, Canada. In Mol Cytogenet, 2013
Differences in hybridization between homologs were non-random for 8 genomic regions (RGS7, CACNA1B, GABRA5, SNRPN, HERC2, PMP22:IVS3, ADORA2B:IVS1, ACR) and were not unique to known imprinted domains or specific chromosomes.
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling.
Minneapolis, United States. In Cell Biochem Biophys, 2008
Four proteins in this group, RGS6, RGS7, RGS9, and RGS11, share a common molecular organization of three modules: (i) the catalytic RGS domain, (ii) a GGL domain that recruits G beta(5), an outlying member of the G protein beta subunit family, and (iii) a DEP/DHEX domain that mediates interactions with the membrane anchor proteins R7BP and R9AP.