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Regulator of G-protein signaling 5

RGS5, regulator of G-protein signaling 5
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: RGS, RGS2, RGS4, RGS16, GPCR
Papers using RGS5 antibodies
Contractile smooth muscle cells derived from hair-follicle stem cells.
Emanueli Costanza, In PLoS ONE, 2007
... CD73, αSMA, KDR, Oct3/4 and PDGFRβ antibodies were from Santa Cruz (Santa Cruz, USA), rabbit anti-RGS5 antibody was from Invitrogen, calponin1 antibody was from Epitomics (Burlingame, USA), CD34 and ...
Papers on RGS5
Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
Kimura et al., Chiba, Japan. In J Recept Signal Transduct Res, Feb 2016
To evaluate intrinsic potency of these RGS proteins, we compared inhibitory effects of RGS1, RGS2, RGS3, RGS4, RGS5, RGS8 and RGS16 on AT1 receptor signaling.
The pericyte antigen RGS5 in perivascular soft tissue tumors.
James et al., Los Angeles, United States. In Hum Pathol, Jan 2016
RGS5, regulator of G-protein signaling 5, is a novel pericyte antigen with increasing use in animal models.
Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation.
Sedding et al., Hannover, Germany. In Arterioscler Thromb Vasc Biol, Jan 2016
OBJECTIVE: Regulator of G-protein signaling 5 (RGS5) is abundantly expressed in vascular smooth muscle cells (SMCs) and inhibits G-protein signaling by enhancing the guanosine triphosphate-hydrolyzing activity of Gα-subunits.
Gene expression alterations associated with outcome in aromatase inhibitor-treated ER+ early-stage breast cancer patients.
Ditzel et al., Odense, Denmark. In Breast Cancer Res Treat, Dec 2015
Twenty-six genes, including TFF3, DACH1, RGS5, and GHR, were shown to exhibit altered expression in tumors from patients with recurrence versus non-recurrent (fold change ≥1.5, p < 0.05), and the gene expression alterations were confirmed using qRT-PCR.
Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia.
Ganss et al., Australia. In Sci Transl Med, Jul 2015
We identified the role of regulator of G protein (heterotrimeric guanine nucleotide-binding protein) signaling 5 (RGS5) in blood pressure regulation during pregnancy and preeclampsia.
Overexpression of the regulator of G-protein signaling 5 reduces the survival rate and enhances the radiation response of human lung cancer cells.
Chen et al., Guangzhou, China. In Oncol Rep, Jun 2015
Regulator of G protein signaling 5 (RGS5) belongs to the R4 subfamily of RGS proteins, a family of GTPase activating proteins, which is dynamically regulated in various biological processes including blood pressure regulation, smooth muscle cell pathology, fat metabolism and tumor angiogenesis.
Endogenous brain pericytes are widely activated and contribute to mouse glioma microvasculature.
Bengzon et al., Lund, Sweden. In Plos One, 2014
GL261 mouse glioma was orthotopically implanted in mice expressing green fluorescent protein (GFP) under the pericyte marker regulator of G protein signaling 5 (RGS5).
Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations.
Liu et al., Hohhot, China. In Genet Mol Res, 2014
Genetic variants of the RGS5 gene are believed to be risk factors for hypertension and cardiovascular diseases.
Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function.
Blumer et al., Philadelphia, United States. In Prog Mol Biol Transl Sci, 2014
Among members of this family, RGS2 and RGS5 have been shown to play key roles in cardiac and smooth muscle function by tightly regulating signaling pathways that are activated through Gq/11 and Gi/o classes of heterotrimeric G proteins.
Keeping the Balance Right: Regulator of G Protein Signaling 5 in Vascular Physiology and Pathology.
Ganss, Perth, Australia. In Prog Mol Biol Transl Sci, 2014
Among RGS proteins, RGS5 is prominently expressed in arterial vascular smooth muscle cells (vSMC) suggesting an important role in vascular function.
Regulator of G-protein signaling 5 (RGS5) protein: a novel marker of cancer vasculature elicited and sustained by the tumor's proangiogenic microenvironment.
Bani et al., Milano, Italy. In Cell Mol Life Sci, 2012
demonstrate RGS5 in the blood vessels of other cancer models endowed with a proangiogenic environment, such as human melanoma and renal carcinoma xenografts
The relationship between RGS5 expression and cancer differentiation and metastasis in non-small cell lung cancer.
Chen et al., Nanjing, China. In J Surg Oncol, 2012
Low expression of RGS5 was strongly associated with cancer vasculature invasion and lymph node metastasis in non-small cell lung cancer.
Origin-specific epigenetic program correlates with vascular bed-specific differences in Rgs5 expression.
Heximer et al., Toronto, Canada. In Faseb J, 2012
Vessel bed-specific changes in regulation of Rgs5 expression occurred during blood vessel maturation.
Loss of regulator of G protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance.
Tang et al., Wuhan, China. In Plos One, 2011
Results indicate the role of RGS5 in obesity-associated metabolic dysfunction and insulin sensitivity.
Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans.
Adeyemo et al., Washington, D.C., United States. In J Hypertens, 2011
examined polymorphisms in three genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans
Normalization of the vasculature for treatment of cancer and other diseases.
Jain et al., Boston, United States. In Physiol Rev, 2011
More recently, genetic and pharmacological approaches have begun to unravel some other key regulators of vascular normalization such as proteins that regulate tissue oxygen sensing (PHD2) and vessel maturation (PDGFRβ, RGS5, Ang1/2, TGF-β).
A unifying hypothesis for scleroderma: identifying a target cell for scleroderma.
Schwartz et al., Seattle, United States. In Curr Rheumatol Rep, 2011
Regulator of G-protein signaling 5 (RGS5), a regulator of vasoactive G-protein-coupled receptors, is a cell type-specific marker of pericytes and scleroderma myofibroblasts.
Regulator of G protein signaling 5: a new player in vascular remodeling.
Ganss et al., Perth, Australia. In Trends Cardiovasc Med, 2009
One family member, RGS5, has recently been identified as a key regulator of vascular remodeling and pericyte maturation in tumors.
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators.
Varshavsky et al., Pasadena, United States. In Nature, 2005
The levels of regulatory proteins bearing N-terminal cysteine, such as RGS4, RGS5 and RGS16, are greatly increased in mouse ATE1-/- embryos, which lack arginylation.
Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.
Duzic et al., United States. In Nat Biotechnol, 1999
A cDNA product identified from the inhibitor screen encodes a previously identified regulator of G-protein signaling, human RGS5.
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