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Regulator of G-protein signaling 3

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RGS, RGS2, CAN, RGS4, RGS5
Papers on RGS3
PDZ-Reactive Peptide Activates Ephrin-B Reverse Signaling and Inhibits Neuronal Chemotaxis.
Xia et al., Hong Kong, Hong Kong. In Acs Chem Biol, Feb 2016
Our work provides direct evidence that PDZ-RGS3 bridges ephrin-B reverse signaling and SDF-1 induced G protein signaling for the first time.
Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
Kimura et al., Chiba, Japan. In J Recept Signal Transduct Res, Feb 2016
To evaluate intrinsic potency of these RGS proteins, we compared inhibitory effects of RGS1, RGS2, RGS3, RGS4, RGS5, RGS8 and RGS16 on AT1 receptor signaling.
Elevated microRNA-25 inhibits cell apoptosis in lung cancer by targeting RGS3.
Xia et al., Wuhan, China. In In Vitro Cell Dev Biol Anim, Jan 2016
Here, we reported that miR-25 is dramatically upregulated in NSCLC tissues and negatively correlated with RGS3 protein.
R4 Regulator of G Protein Signaling (RGS) Proteins in Inflammation and Immunity.
Druey et al., Bethesda, United States. In Aaps J, Dec 2015
The R4/B subfamily-the focus of this review-includes RGS1-5, 8, 13, 16, 18, and 21, which are the smallest RGS proteins in size, with the exception of RGS3.
PDZ Protein Regulation of G Protein-Coupled Receptor Trafficking and Signaling Pathways.
Ferguson et al., London, Canada. In Mol Pharmacol, Oct 2015
These PDZ domain-containing proteins include the membrane-associated guanylate-like kinases [postsynaptic density protein of 95 kilodaltons; synapse-associated protein of 97 kilodaltons; postsynaptic density protein of 93 kilodaltons; synapse-associated protein of 102 kilodaltons; discs, large homolog 5; caspase activation and recruitment domain and membrane-associated guanylate-like kinase domain-containing protein 3; membrane protein, palmitoylated 3; calcium/calmodulin-dependent serine protein kinase; membrane-associated guanylate kinase protein (MAGI)-1, MAGI-2, and MAGI-3], Na(+)/H(+) exchanger regulatory factor proteins (NHERFs) (NHERF1, NHERF2, PDZ domain-containing kidney protein 1, and PDZ domain-containing kidney protein 2), Golgi-associated PDZ proteins (Gα-binding protein interacting protein, C-terminus and CFTR-associated ligand), PDZ domain-containing guanine nucleotide exchange factors (GEFs) 1 and 2, regulator of G protein signaling (RGS)-homology-RhoGEFs (PDZ domain-containing RhoGEF and leukemia-associated RhoGEF), RGS3 and RGS12, spinophilin and neurabin-1, SRC homology 3 domain and multiple ankyrin repeat domain (Shank) proteins (Shank1, Shank2, and Shank3), partitioning defective proteins 3 and 6, multiple PDZ protein 1, Tamalin, neuronal nitric oxide synthase, syntrophins, protein interacting with protein kinase C α 1, syntenin-1, and sorting nexin 27.
The roles of ribosomal protein S19 C-terminus in a shortened neutrophil lifespan through delta lactoferrin.
Nakasho et al., Nishinomiya, Japan. In Immunobiology, Sep 2015
In contrast to an original ligand C5a, RP S19 polymer induces not only inhibition of the guanine nucleotide exchange factor activity but also initiation of the regulator of G protein signaling 3 (RGS3) promoter in a RP S19 C-terminus dependent manner.
Regulator of G protein signaling 3 protects against cardiac hypertrophy in mice.
Huang et al., Wuhan, China. In J Cell Biochem, 2014
Regulator of G protein signaling 3 (RGS3) is a negative regulator of G protein-mediated signaling.
Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.
Trejo et al., In J Biol Chem, 2014
We further found that ectopic expression of R4 subfamily members RGS2, RGS3, RGS4, and RGS5 reduced activated PAR1 wild-type signaling, whereas signaling by the PAR1 AKKAA mutant was minimally affected.
Mechanisms of the 14-3-3 protein function: regulation of protein function through conformational modulation.
Obsil et al., Praha, Czech Republic. In Physiol Res, 2013
In this minireview, we focus on mechanisms of the 14-3-3 protein-dependent regulation of three important 14-3-3 binding partners: yeast neutral trehalase Nth1, regulator of G-protein signaling 3 (RGS3), and phosducin.
RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation.
Dulin et al., Chicago, United States. In Am J Physiol Lung Cell Mol Physiol, 2013
Herein we demonstrated abundant expression of the Gi/Gq-specific RGS3 in activated T cells, and that diminished RGS3 expression in a T cell thymoma increased cytokine-induced migration.
RGS expression in cancer: oncomining the cancer microarray data.
Dulin et al., Chicago, United States. In J Recept Signal Transduct Res, 2013
We focused on the largest R4 sub-family of RGS proteins, containing RGS1, RGS2, RGS3, RGS4, RGS5, RGS8, RGS13, RGS16 and RGS18.
Regulator of G-protein signaling 3 isoform 1 (PDZ-RGS3) enhances canonical Wnt signaling and promotes epithelial mesenchymal transition.
Kehrl et al., Bethesda, United States. In J Biol Chem, 2012
Here we show that Wnt signaling enhances the expression of another RGS domain-containing protein, PDZ-RGS3.
[Identification of differentially expressed genes related to blastic crisis in chronic myeloid leukemia].
Xiao et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2012
CD40, CCR3, LGALS3, RGS3, CEACAM3 and the related transcription factors RAC1, CTNNB1, TP53, and NF-κB, all as the nodes of the entire regulatory network, were presumed to play key roles in disease progression.
Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G protein signaling 3 (RGS3) function.
Obsil et al., Praha, Czech Republic. In J Biol Chem, 2012
Results suggest that the 14-3-3 protein binding affects the structure of the Galpha interaction portion of RGS3 as well as sterically blocks the interaction between the RGS domain and the Galpha subunit of heterotrimeric G proteins.
Essential role of PDZ-RGS3 in the maintenance of neural progenitor cells.
Lu et al., Duarte, United States. In Stem Cells, 2010
Results reveal an essential role of PDZ-RGS3 in maintaining the balance between self-renewal and differentiation of neural progenitor cells and provide genetic evidence linking PDZ-RGS3 to ephrin-B reverse signaling.
14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3).
Obsil et al., Praha, Czech Republic. In J Struct Biol, 2010
14-3-3 protein binding induces structural changes in both the N-terminal part and the C-terminal RGS domain of phosphorylated RGS3 molecule
Genomic assessment of follicular marker genes as pregnancy predictors for human IVF.
Sirard et al., Canada. In Mol Hum Reprod, 2010
Regulator of G-protein signalling 3 (RGS3) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure.
Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase.
Yamamoto et al., Kumamoto, Japan. In Lab Invest, 2009
in apoptosis-initiated cells, the ligand-dependent C5aR-mediated dual signal affects the fate of cells, either apoptosis execution or survival, through regulation of RGS3 gene expression and subsequent modulation of ERK signal.
Regulators of G protein signalling: a spotlight on emerging functions in the cardiovascular system.
Chidiac et al., Mannheim, Germany. In Curr Opin Pharmacol, 2007
Recent data show that the 519-amino acid RGS3, the only RGS protein with an additional G protein betagamma dimer binding domain, largely alters the signalling of G(i) proteins to the monomeric GTPases Rac1 and RhoA in cardiomyocytes.
Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction.
Flanagan et al., Boston, United States. In Cell, 2001
We describe a cytoplasmic protein, PDZ-RGS3, which binds B ephrins through a PDZ domain, and has a regulator of heterotrimeric G protein signaling (RGS) domain.
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