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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulator of G-protein signaling 2, 24kDa

RGS2, regulator of G-protein signaling 2
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: RGS, RGS4, V1a, CAN, HAD
Papers using RGS2 antibodies
RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes
Chidiac Peter et al., In The Journal of Cell Biology, 2005
... The purified RGS2 peptide was made by custom peptide synthesis, and the RGS2-ala mutants were made by custom gene synthesis (Genscript Corporation) ...
Papers on RGS2
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.
Hepler et al., Atlanta, United States. In Mol Pharmacol, Feb 2016
Here, we review and highlight the current knowledge of specific RGS proteins (RGS2, RGS4, RGS7, RGS9-2, and RGS14) that have been clearly demonstrated to serve critical roles in modulating synaptic signaling and plasticity throughout the brain, and we consider their potential as future therapeutic targets.
The angiotensin II receptor antagonist, losartan, enhances regulator of G protein signaling 2 mRNA expression in vascular smooth muscle cells of Wistar rats.
Uehara et al., Shijiazhuang, China. In Hypertens Res, Feb 2016
UNASSIGNED: Angiotensin II (Ang II) reportedly enhances regulator of G-protein signaling 2 (RGS2), thus making a negative feedback loop for Ang II signal transduction.
Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
Kimura et al., Chiba, Japan. In J Recept Signal Transduct Res, Feb 2016
To evaluate intrinsic potency of these RGS proteins, we compared inhibitory effects of RGS1, RGS2, RGS3, RGS4, RGS5, RGS8 and RGS16 on AT1 receptor signaling.
Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: Molecular Basis for Gα Selectivity.
Tesmer et al., United States. In J Biol Chem, Feb 2016
In contrast, only one RGS protein, RGS2, is known to be selective for Gαq/11.
Novel developments in genetic and epigenetic mechanisms of anxiety.
Domschke et al., Würzburg, Germany. In Curr Opin Psychiatry, Jan 2016
Variants in RGS2 and ASIC1 genes were linked to panic disorder, with the latter also being implicated in SAD treatment response.
Impaired response of regulator of Gαq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats.
Uehara et al., Shijiazhuang, China. In Hypertens Res, Dec 2015
The expression of regulatory protein of Gαq signaling-2 (RGS2) mRNA in the aortic walls in response to Ang-II infusion was lower in Dahl S than Dahl R rats (P<0.05).
The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Chen et al., Winston-Salem, United States. In Neuroscience, Nov 2015
The mRNA levels of RGS2 and RGS4 in both the VTA and NAc were positively correlated with the rate of AMPH intake.
Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells.
van Calker et al., Freiburg, Germany. In Plos One, 2014
Expression of RGS-2 mRNA as well as RGS2 protein was increased up to 30-fold by adenosine agonists in astrocytes.
Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function.
Blumer et al., Philadelphia, United States. In Prog Mol Biol Transl Sci, 2014
Among members of this family, RGS2 and RGS5 have been shown to play key roles in cardiac and smooth muscle function by tightly regulating signaling pathways that are activated through Gq/11 and Gi/o classes of heterotrimeric G proteins.
Time course of the response to ACTH in pig: biological and transcriptomic study.
Mormède et al., France. In Bmc Genomics, 2014
In particular, DDIT4, DUSP1, FKBP5, IL7R, NFKBIA, PER1, RGS2 and RHOB were shown to be connected to each other by the glucocorticoid receptor NR3C1.
Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ.
Wong et al., Hong Kong, Hong Kong. In Bmc Cancer, 2014
Other effectors of Gαq including RGS2 and p63RhoGEF were unable to interact with Fhit.
Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease.
Brouillet et al., Fontenay-aux-Roses, France. In Front Cell Neurosci, 2013
Recent research shows that some of these striatal markers have a pro-survival/neuroprotective role in neurons (e.g., MSK1, A2A, and CB1 receptors) whereas others enhance the susceptibility of striatal neurons to mHtt (e.g., Rhes, RGS2, D2 receptors).
Genetic factors in anxiety disorders.
Maron et al., Würzburg, Germany. In Mod Trends Pharmacopsychiatri, 2012
Presently available clinical genetic studies point to a considerable heritability of anxiety disorders (30-67%), with multiple vulnerability genes such as 5-HT1A, 5-HTT, MAO-A, COMT, CCK-B, ADORA2A, CRHR1, FKBP5, ACE, RGS2/7 and NPSR1 suggested by molecular genetic association studies.
Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.
Blumer et al., Saint Louis, United States. In J Biol Chem, 2012
systemic or endothelium-specific RGS2 deficiency causes endothelial dysfunction resulting in impaired EDHF-dependent vasodilatation.
RGS2 is a negative regulator of STAT3-mediated Nox1 expression.
Baek et al., Taegu, South Korea. In Cell Signal, 2012
RGS2 negatively regulates TLR2-mediated Nox1 expression via PKC-eta and PLD2 pathway.
RGS2-mediated intracellular Ca2+ level plays a key role in the intracellular replication of Brucella abortus within phagocytes.
Kim et al., Japan. In J Infect Dis, 2012
These results indicate that Brucella abortus infection induces host RGS2 expression and that up-regulation of [Ca(2+)](i) levels is an essential factor for the intracellular survival of the bacteria within phagocytes.
Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles.
Guo et al., Lexington, United States. In J Biol Chem, 2012
Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2
β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.
Newton et al., Calgary, Canada. In Proc Natl Acad Sci U S A, 2012
Data show that Rgs2-deficient mice revealed enhanced bronchoconstriction to spasmogens and an absence of beta(2)-adrenoceptor agonist (LABA)-induced bronchoprotection.
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors.
Muallem et al., Dallas, United States. In Nat Cell Biol, 2005
The RGS2 proteins recognize GPCRs to confer signalling specificity.
RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III.
Kehrl et al., Bethesda, United States. In Nature, 2001
Here we report that RGS2 reduces cAMP production by odorant-stimulated olfactory epithelium membranes, in which the alpha(s) family member alpha(olf) links odorant receptors to adenylyl cyclase activation.
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