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Regulator of G-protein signaling 13

RGS18, RGS13, regulator of G protein signaling 13
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RGS, RGS16, RGS2, regulator of G protein signaling, HAD
Papers on RGS18
Modulating platelet reactivity through control of RGS18 availability.
Brass et al., Philadelphia, United States. In Blood, Jan 2016
We have shown previously that a critical node in the G-protein signaling network in platelets is formed by a scaffold protein, spinophilin (SPL), the tyrosine phosphatase, Src homology region 2 domain-containing phosphatase-1 (SHP-1), and the regulator of G-protein signaling family member, RGS18.
R4 Regulator of G Protein Signaling (RGS) Proteins in Inflammation and Immunity.
Druey et al., Bethesda, United States. In Aaps J, Dec 2015
Prominent roles in the trafficking of B and T lymphocytes and macrophages have been described for RGS1, RGS13, and RGS16, while RGS18 appears to control platelet and osteoclast functions.
Identification of extracellularly phosphorylated membrane proteins.
Schrader et al., Düsseldorf, Germany. In Proteomics, Oct 2015
Using this approach we identified novel phosphorylation sites on five ectophosphoproteins (NOTCH1, otopetrin 1, regulator of G-protein signalling 13 (RGS13), protein tyrosine phosphatase receptor type D isoform 3 (PTPRD), usherin isoform B (USH2A)).
The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis.
Khasawneh et al., Pomona, United States. In Biochem Biophys Res Commun, Aug 2015
RGS18 is identified as an R4 subfamily member of this family with specific expression in hematopoietic progenitors, myeloerythroid cells, megakaryocytes and platelets.
Identification of novel immune phenotypes for allergic and nonallergic childhood asthma.
Schaub et al., München, Germany. In J Allergy Clin Immunol, 2015
In parallel, expressions of anti-inflammatory IL37, proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2), and the neutrophil-associated genes CD93, triggering receptor expressed on myeloid cells 1 (TREM1), and regulator of G-protein signaling 13 (RGS13) were increased in patients with NA.
Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).
Brass et al., Philadelphia, United States. In Plos One, 2014
This node is comprised of a scaffold protein (spinophilin, SPL), a protein tyrosine phosphatase (SHP-1), and either of the two members of the Regulators of G protein Signaling family predominantly expressed in platelets (RGS10 or RGS18).
Plasma profiling reveals three proteins associated to amyotrophic lateral sclerosis.
Nilsson et al., Stockholm, Sweden. In Ann Clin Transl Neurol, 2014
RESULTS: Disease-associated significant differences were observed and replicated for profiles from antibodies targeting the proteins: neurofilament medium polypeptide (NEFM), solute carrier family 25 (SLC25A20), and regulator of G-protein signaling 18 (RGS18).
Regulators of G protein signaling are up-regulated in aspirin-resistant platelets from patients with metabolic syndrome.
Huo et al., In Pharmazie, 2014
Although there were no clinical differences between the two groups, transcripts of RGS2, RGS10, and RGS18 were significantly higher in aspirin-resistant patients than in aspirin-sensitive patients.
Regulator of G-protein signaling 18 controls both platelet generation and function.
Bono et al., Toulouse, France. In Plos One, 2013
RGS18 is a myeloerythroid lineage-specific regulator of G-protein signaling, highly expressed in megakaryocytes (MKs) and platelets.
Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice.
Mountz et al., Birmingham, United States. In Arthritis Rheum, 2013
This study was undertaken to determine the mechanisms by which RGS13 promotes the generation of pathogenic autoantibodies in germinal centers (GCs), using BXD2-Rgs13-/- mice.
Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets.
Smolenski et al., Dublin, Ireland. In Plos One, 2012
Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein that turns off Gq signaling in platelets.
Regulators of G protein signaling: role in hematopoiesis, megakaryopoiesis and platelet function.
Freson et al., Leuven, Belgium. In J Thromb Haemost, 2012
More recent studies also focused on their expression in platelets, and for R4 RGS subfamily members RGS2, RGS16 and RGS18, it could be demonstrated that they regulate megakaryopoiesis and/or platelet function.
Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system.
Freson et al., Leuven, Belgium. In Faseb J, 2012
study is the first to show that RGS18 regulates megakaryopoiesis but also reveals its unexpected role in ciliogenesis, at least in lower vertebrates, via interference with Wnt signaling.
Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets.
Smolenski et al., Dublin, Ireland. In Blood, 2012
These findings indicate cross-talk between platelet activation and inhibition pathways at the level of RGS18 and Gq.
A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.
Brass et al., Philadelphia, United States. In Blood, 2012
Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.
p53 negatively regulates RGS13 protein expression in immune cells.
Druey et al., Bethesda, United States. In J Biol Chem, 2011
p53 may modulate immune responses through suppression of RGS13 transcription in mast cells and B cells
Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation.
Druey et al., Bethesda, United States. In J Mol Cell Biol, 2010
RGS13 turnover was significantly reduced in cells stimulated with cAMP, which was reversed by expression of the PKA-specific inhibitory peptide PKI.
Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.
Mountz et al., Birmingham, United States. In Nat Immunol, 2008
Production of IL-17 correlates with upregulated expression of the genes Rgs13 and Rgs16, which encode regulators of G-protein signaling, and results in suppression of the B cell chemotactic response to the chemokine CXCL12.
Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13.
Druey et al., Bethesda, United States. In Nat Immunol, 2008
Here we show that RGS13 inhibited allergic responses by physically interacting with the regulatory p85alpha subunit of phosphatidylinositol-3-OH kinase in mast cells and disrupting its association with an FcepsilonRI-activated scaffolding complex.
Regulation of chemokine-induced lymphocyte migration by RGS proteins.
Kehrl et al., Bethesda, United States. In Methods Enzymol, 2003
Among RGS proteins with the highest levels of expression are RGS1, RGS2, RGS10, RGS13, RGS14, RGS16, and RGS19.
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