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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

MicroRNA 16-1

RGS16, miR-16, RGS14, miR-16-1, glycerophosphodiester phosphodiesterase
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: miR, CAN, RGS, POLYMERASE, V1a
Papers on RGS16
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.
Review
New
Hepler et al., Atlanta, United States. In Mol Pharmacol, Feb 2016
Here, we review and highlight the current knowledge of specific RGS proteins (RGS2, RGS4, RGS7, RGS9-2, and RGS14) that have been clearly demonstrated to serve critical roles in modulating synaptic signaling and plasticity throughout the brain, and we consider their potential as future therapeutic targets.
Quantitative evaluation of first, second, and third generation hairpin systems reveals the limit of mammalian vector-based RNAi.
New
Haley et al., San Francisco, United States. In Rna Biol, Feb 2016
Thus, we used quantitative cell-based assays to compare separate third generation artificial miRNA systems, miR-E (based on miR-30a) and miR-3G (based on miR-16-2 and first described in this study) to widely-adopted, first and second generation formats in both Pol-II and Pol-III expression vector contexts.
Direct detection of endogenous MicroRNAs and their post-transcriptional modifications in cancer serum by capillary electrophoresis-mass spectrometry.
New
Berezovski et al., Ottawa, Canada. In Anal Bioanal Chem, Feb 2016
Using the CE-MS method, we detected two endogenous human circulating miRNAs, a 23-nucleotide long 5'-phosporylated miRNA with 3'-uridylation (iso-miR-16-5p), and a 22-nucleotide long 5'-phosporylated miRNA (miR-21-5p) isolated from B-cell chronic lymphocytic leukemia serum.
Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
New
Kimura et al., Chiba, Japan. In J Recept Signal Transduct Res, Feb 2016
To evaluate intrinsic potency of these RGS proteins, we compared inhibitory effects of RGS1, RGS2, RGS3, RGS4, RGS5, RGS8 and RGS16 on AT1 receptor signaling.
Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion.
New
Han et al., Beijing, China. In Oncotarget, Feb 2016
Furthermore, we demonstrated that ARHGDIA is a potential target of miR-151-5p and miR-16 in gliomas.
Borrelia miyamotoi Disease: Neither Lyme Disease Nor Relapsing Fever.
Review
New
Lepore et al., Grafton, United States. In Clin Lab Med, Dec 2015
A diagnosis of BMD is confirmed by polymerase chain reaction analysis of acute blood samples, or by seroconversion using a recombinant glycerophosphodiester phosphodiesterase enzyme immunoassay.
Altered miRNA expression in pulmonary sarcoidosis.
New
Brzeziańska-Lasota et al., Łódź, Poland. In Bmc Med Genet, Dec 2015
METHODS: The aim of the study was to investigate the expression of selected miRNAs (miR-let7f, miR-15b, miR-16, miR-20a, miR-27b, miR-128a, miR-130a, miR-192 miR-221, miR-222) in patients with pulmonary sarcoidosis (n = 94) and controls (n = 50).
MicroRNAs in rheumatoid arthritis: altered expression and diagnostic potential.
Review
New
Knip et al., Petrozavodsk, Russia. In Autoimmun Rev, Nov 2015
MiR-16, miR-146a/b, miR-150, miR-155, and miR-223 described here were shown to be overexpressed at the systemic level: in both the periphery and RA joints.
[Non-coding RNAs in castration-resistant prostate cancer].
Review
New
Jiang et al., In Zhonghua Nan Ke Xue, Nov 2015
Some of the ncRNAs act as cancer genes, such as miR-19a, miR-125b, miR-616, miR-7, miR-221, MALAT-1, and PRNCR1, which are upregulated in castration-resistant prostate cancer (CRPC) tissues or cell lines, and promote the development and progression of CRPC, some act as tumor suppressor genes, including miR-185, miR-342, miR-15, miR-16, and miR-146, which are downregulated in CRPC tissues or cell lines and inhibit or delay the occurrence of CRPC, and still others, such as miR-7, miR-19a, miR-125b, miR-221, and MALAT-1, are differentially expressed in the serum or tissue and can be used as potential biomarkers for the early diagnosis and prognosis of CRPC.
miRNA-15a/16: as tumor suppressors and more.
Review
Chu et al., Shanghai, China. In Future Oncol, 2014
Since their first discovery in chronic lymphocytic leukemia, miR-15a and miR-16 have been reported to act as tumor suppressors or potential oncomiRs in different types of cancer.
Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis.
Impact
Kang et al., Princeton, United States. In Cancer Cell, 2013
Importantly, serum levels of sICAM1 and two osteoclast miRNAs, miR-16 and miR-378, which are elevated in osteoclast differentiation, correlate with bone metastasis burden.
GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK.
Impact
Sockanathan et al., Baltimore, United States. In Science, 2013
The six-transmembrane protein glycerophosphodiester phosphodiesterase 2 (GDE2) induces spinal motor neuron differentiation by inhibiting Notch signaling in adjacent motor neuron progenitors.
Vector-based miR-15a/16-1 plasmid inhibits colon cancer growth in vivo.
GeneRIF
Deng et al., Chengdu, China. In Cell Biol Int, 2012
The miR 16-1 inhibited cell proliferation and induced cycle arrest by targeting CCNB1, which increased the percentage of cells in G2/M phase.
MicroRNA 16 enhances differentiation of human bone marrow mesenchymal stem cells in a cardiac niche toward myogenic phenotypes in vitro.
GeneRIF
Shan et al., Guangzhou, China. In Life Sci, 2012
MiR-16 enhances G1 phase arrest in mesenchymal stem cells (MSCs), contributing to the differentiation of MSCs toward myogenic phenotypes when in a cardiac niche.
RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.
GeneRIF
Druey et al., Bethesda, United States. In J Immunol, 2012
RGS16-mediated confinement of T cells to Schistosome granulomas mitigates widespread cytokine-mediated pulmonary inflammation.
Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16.
GeneRIF
Kreth et al., München, Germany. In Shock, 2012
Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16
miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene.
GeneRIF
Chen et al., Omaha, United States. In Plos One, 2011
miR-16 targets SMRT and modulates NF-kappaB-regulated transactivation of the IL-8 gene.
Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia.
Impact
Croce et al., Columbus, United States. In Jama, 2011
OBJECTIVE: To determine whether the microRNA miR-15a/miR-16-1 cluster (located at 13q), tumor protein p53 (TP53, located at 17p), and miR-34b/miR-34c cluster (located at 11q) are linked in a molecular pathway that explains the pathogenetic and prognostic implications (indolent vs aggressive form) of recurrent 13q, 17p, and 11q deletions in CLL.
miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants.
Impact
GeneRIF
Kellermann et al., Paris, France. In Science, 2010
study shows SERT is a target of miR-16; miR-16 is expressed at higher level in noradrenergic than serotonergic cells; its reduction in noradrenergic neurons causes SERT expression; propose miR-16 contributes to therapeutic action of SSRI antidepressants
MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation.
Impact
Liu et al., Bethesda, United States. In Nat Immunol, 2010
Here we show that during human monocyte-macrophage differentiation, expression of the microRNAs miR-223, miR-15a and miR-16 decreased considerably, which led to higher expression of the serine-threonine kinase IKKalpha in macrophages.
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