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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Paired-like homeodomain 2

RGS, Pitx2
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, GPCR, RGS4, HAD
Papers using RGS antibodies
The high-molecular-weight cytochrome c Cyc2 of Acidithiobacillus ferrooxidans is an outer membrane protein
Supplier
Shi Liang et al., In Frontiers in Microbiology, 2001
... RGS-His antibody was used for detecting the recombinant protein tagged with RGS-His epitope by Western blot analysis (QIAGEN, Valencia, CA, USA) ...
The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines.
Supplier
Jin Dong-Yan, In PLoS ONE, 2000
... anti-HA, clone 3F10 (Roche), mouse monoclonal anti-FLAG M2 (Sigma-Aldrich), mouse monoclonal anti-penta-His (Qiagen), mouse monoclonal anti-RGS-His (Qiagen), mouse monoclonal anti-S-tag (Novagen), ...
Papers on RGS
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.
Review
New
Hepler et al., Atlanta, United States. In Mol Pharmacol, Feb 2016
The regulator of G protein signaling (RGS) family of proteins serves critical roles in G protein-coupled receptor (GPCR) and heterotrimeric G protein signal transduction.
Reference genes selection and relative expression analysis from Shiraia sp. SUPER-H168 productive of hypocrellin.
New
Cai et al., Wuxi, China. In Gene, Feb 2016
We selected and assessed nine candidate RGs in the presence and absence of hypocrellin biosynthesis using geNorm and NormFinder algorithms.
The angiotensin II receptor antagonist, losartan, enhances regulator of G protein signaling 2 mRNA expression in vascular smooth muscle cells of Wistar rats.
New
Uehara et al., Shijiazhuang, China. In Hypertens Res, Feb 2016
Ang II subtype-2 receptor (AT2R) was not involved in Ang II-mediated RGS expression.
TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians.
New
Tian et al., Shanghai, China. In Cardiovasc Res, Feb 2016
METHODS AND RESULTS: We screened six candidate genes (CAV1, KCNJ2, KCNQ1, NKX2.5, PITX2, and TBX5) for novel mutations in 139 patients of Chinese descent with early-onset AF and 576 controls.
Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: Molecular Basis for Gα Selectivity.
New
Tesmer et al., United States. In J Biol Chem, Feb 2016
UNASSIGNED: Regulator of G protein signaling (RGS) proteins interact with activated Gα subunits via their RGS domains and accelerate the hydrolysis of GTP.
RGS proteins destroy spare receptors: Effects of GPCR-interacting proteins and signal deamplification on measurements of GPCR agonist potency.
Review
New
Chidiac, Canada. In Methods, Feb 2016
Many GPCRs are able to activate multiple distinct signaling pathways, and these may include biochemical cascades activated via either heterotrimeric G proteins or by β-arrestins.
Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase-Extracellular Signal-Regulated Protein Kinase 1/2 Signaling.
Review
New
Yuan et al., Changsha, China. In Hypertension, Jan 2016
Regulator of G-protein signaling 10 (RGS10) is an important member of the RGS family and produces biological effects in multiple organs.
PANCR, the PITX2 Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression.
New
Smith et al., Cleveland, United States. In Circ Arrhythm Electrophysiol, Jan 2016
METHODS AND RESULTS: RNA sequencing performed on human left/right pairs identified an intergenic long noncoding RNA adjacent to the PITX2 gene, which we have named PANCR (PITX2 adjacent noncoding RNA).
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
New
Impact
International Stroke Genetics Consortium (ISGC) et al., In Lancet Neurol, Jan 2016
Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10(-19); joint OR 1·37, 1·30-1·45, p=2·79 × 10(-32)) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10(-7); joint OR 1·17, 1·11-1·23, p=2·29 × 10(-10)) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10(-8); joint OR 1·24, 1·15-1·33, p=4·52 × 10(-9)) for large artery atherosclerosis stroke.
Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer.
Review
New
Murph et al., Athens, United States. In Future Med Chem, Aug 2015
More than 30 regulators of G protein signaling (RGS) proteins encompass the RGS protein superfamily of critical regulators essential to cellular homeostasis.
RGS Redundancy and Implications in GPCR-GIRK Signaling.
Review
Doupnik, Tampa, United States. In Int Rev Neurobiol, 2014
Regulators of G protein signaling (RGS proteins) are key components of GPCR complexes, interacting directly with G protein α-subunits to enhance their intrinsic GTPase activity.
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
Impact
International Stroke Genetics Consortium et al., London, United Kingdom. In Lancet Neurol, 2012
FINDINGS: We verified previous associations for cardioembolic stroke near PITX2 (p=2·8×10(-16)) and ZFHX3 (p=2·28×10(-8)), and for large-vessel stroke at a 9p21 locus (p=3·32×10(-5)) and HDAC9 (p=2·03×10(-12)).
Endocytosis of the seven-transmembrane RGS1 protein activates G-protein-coupled signalling in Arabidopsis.
Impact
Jones et al., Chapel Hill, United States. In Nat Cell Biol, 2012
The Arabidopsis thaliana heterotrimeric Gα protein self-activates without accessory proteins, and is kept in its resting state by the negative regulator, AtRGS1 (regulator of G-protein signalling 1), which is the prototype of a seven-transmembrane receptor fused with an RGS domain.
FGF9-Pitx2-FGF10 signaling controls cecal formation in mice.
GeneRIF
Bellusci et al., Los Angeles, United States. In Dev Biol, 2012
Using tissue specific Fgf9 versus Pitx2 loss of function approaches in the gut epithelium and/or mesenchyme, we determined that FGF9 signals to the mesenchyme via Pitx2 to induce mesenchymal Fgf10 expression, which leads to epithelial cecal bud formation.
CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression.
GeneRIF
Ma et al., Beijing, China. In Biochem Biophys Res Commun, 2012
CITED2 variants decreased its ability to mediate the expression of vascular endothelial growth factor (VEGF) and the expression of the paired-like homeodomain transcription factor 2-gamma (PITX2C), both of which are closely related to cardiac development.
Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer.
GeneRIF
Werner et al., Tel Aviv-Yafo, Israel. In Horm Metab Res, 2012
Epigenetic regulation of PITX2 during the course of the disease may lead to orchestrated control of the AR and IGF signaling pathways.
DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients.
GeneRIF
Soltermann et al., Bonn, Germany. In Diagn Mol Pathol, 2012
DNA methylation of PITX2 and SHOX2 is an independent prognostic biomarker for disease progression in non-small-cell lung cancer patients.
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
Impact
Markus et al., Oxford, United Kingdom. In Nat Genet, 2012
We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus.
Regulation of motility of myogenic cells in filling limb muscle anlagen by Pitx2.
GeneRIF
Kioussi et al., Corvallis, United States. In Plos One, 2011
Pitx2 appears to regulate muscle anlagen development by appropriately balancing expression of cytoskeletal and adhesion molecules.
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.
Review
Impact
Siderovski et al., Chapel Hill, United States. In Pharmacol Rev, 2011
This review considers the drug discovery potential of two such components: members of the "regulators of G-protein signaling" (RGS protein) superfamily, as well as their substrates, the heterotrimeric G-protein α subunits.
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