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Retinal G protein coupled receptor

RGR, retinal G protein-coupled receptor
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, CIs, Rhodopsin
Papers on RGR
Effects of Cu(2+) and Zn(2+) on growth and physiological characteristics of green algae, Cladophora.
New
Shi et al., Hefei, China. In Environ Sci Pollut Res Int, Nov 2015
The stress concent of Cu(2+) was strictly correlated with the total soluble sugar content, Chla+Chlb, and MDA in Cladophora, and the stress concent of Zn(2+) was strictly correlated with the relative growth rate (RGR) and MDA of Cladophora.
Effects of the Timing of Herbivory on Plant Defense Induction and Insect Performance in Ribwort Plantain (Plantago lanceolata L.) Depend on Plant Mycorrhizal Status.
New
Biere et al., Wageningen, Netherlands. In J Chem Ecol, Nov 2015
Mycorrhizal infection reduced the relative growth rate (RGR) of later arriving herbivores, associated with a reduction in efficiency of conversion of ingested food rather than a reduction in relative consumption rates.
De novo transcriptome of the European brittle star Amphiura filiformis pluteus larvae.
New
Flammang et al., Mons, Belgium. In Mar Genomics, Oct 2015
Additionally, partial non-visual RGR (retinal G protein coupled receptor) opsin mRNAs were identified,possibly indicating the presence of visual cycle reaction in early pluteus larvae.
The impact of GABA in harpin-elicited biotic stress responses in Nicotiana tabaccum.
New
Türkan et al., İzmir, Turkey. In J Plant Physiol, Oct 2015
RGR, RWC and photosynthetic efficiency were all affected in harpin-infiltrated tobacco leaves, but the rate of decline was more remarkable on RGR.
Spectral Tuning of Phototaxis by a Go-Opsin in the Rhabdomeric Eyes of Platynereis.
New
Jékely et al., Tübingen, Germany. In Curr Biol, Oct 2015
Opsins have been classified into three major families, the r-opsins, the c-opsins, and the Go/RGR opsins, a family uniting Go-opsins, retinochromes, RGR opsins, and neuropsins.
Effect of herbicide resistance endowing Ile-1781-Leu and Asp-2078-Gly ACCase gene mutations on ACCase kinetics and growth traits in Lolium rigidum.
New
Powles et al., Australia. In J Exp Bot, Aug 2015
Relative growth rate (RGR) and components (net assimilation rate, leaf area ratio), resource allocation to different organs, and growth responses in competition with a wheat crop were assessed.
[Expression, purification, and characterization of fusion protein TAT-cytoglobin].
Xu et al., In Sheng Wu Gong Cheng Xue Bao, 2014
Both TAT-Cygb and Cygb pretreatment group could protect Hacat cells against oxidation of H2O2, but only TAT-Cygb treatment group could remedy cells injuried by H2O2 (RGR = 98%), which was significantly different from Cygb treatment group (RGR = 79%).
Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs.
Nishina et al., Bar Harbor, United States. In Plos One, 2013
In Mfrprd6 eyes, a significant 1.5- to 2.0-fold decrease was observed among transcripts of genes linked to retinal degeneration, including those involved in visual cycle (Rpe65, Lrat, Rgr), phototransduction (Pde6a, Guca1b, Rgs9), and photoreceptor disc morphogenesis (Rpgrip1 and Fscn2).
Identification of genomic regions associated with feed efficiency in Nelore cattle.
Regitano et al., São Carlos, Brazil. In Bmc Genet, 2013
The traits analyzed included: average daily gain (ADG), dry matter intake (DMI), feed-conversion ratio (FCR), feed efficiency (FE), residual feed intake (RFI), maintenance efficiency (ME), efficiency of gain (EG), partial efficiency of growth (PEG) and relative growth rate (RGR).
Peptide-mediated targeting of cytokines to tumor vasculature: the NGR-hTNF example.
Review
Gregorc et al., Milano, Italy. In Biodrugs, 2013
In particular, we provide an overview of peptide-cytokine conjugates made with peptides containing the NGR, RGD, isoDGR or RGR sequences and describe, in more details, the biological and pharmacological properties of NGR-hTNF, a peptide-tumor necrosis factor-α conjugate that is currently being tested in phase II and III clinical studies.
High opsin diversity in a non-visual infaunal brittle star.
Flammang et al., Mons, Belgium. In Bmc Genomics, 2013
Finally, two sequences from one putative RGR opsin similar to Sp-opsin 7 were also detected.
The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral.
GeneRIF
Pellicer et al., New York City, United States. In Oncogene, 2011
conclude that the ability of hRgr to activate both Ral and Ras is responsible for its transformation-inducing phenotype and it could be an important contributor in the development of some T-cell malignancies
Screening genes of the visual cycle RGR, RBP1 and RBP3 identifies rare sequence variations.
GeneRIF
Hamel et al., Montpellier, France. In Ophthalmic Genet, 2010
It is likely that mutations in RGR, RBP3, and possibly RBP1 occur rarely in inherited retinal dystrophies.
Accumulation of extracellular RGR-d in Bruch's membrane and close association with drusen at intercapillary regions.
GeneRIF
Fong et al., Los Angeles, United States. In Exp Eye Res, 2009
the exon-skipping variant of RGR (RGR-d) is found in extracellular deposits;at the base of early-stage drusen mounds in the older donors and may precede the formation of these drusen
Retinal pigment epithelium-retinal G protein receptor-opsin mediates light-dependent translocation of all-trans-retinyl esters for synthesis of visual chromophore in retinal pigment epithelial cells.
GeneRIF
Travis et al., United States. In J Biol Chem, 2008
RGR-opsin mediates light-dependent translocation of all-trans-retinyl esters from a storage pool in lipid droplets to an "isomerase pool" in membranes of the endoplasmic reticulum.
Origin of the vertebrate visual cycle.
Review
Tsuda et al., Japan. In Photochem Photobiol, 2007
We identified four genes encoding putative visual cycle proteins, homologs of retinal G protein-coupled receptor (Ci-opsin3), cellular retinaldehyde-binding protein (Ci-CRALBP), beta-carotene 15,15'monooxygenase (Ci-BCO) and RPE-specific 65 kDa protein (Ci-RPE65) in the ascidian, Ciona intestinalis.
Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane.
GeneRIF
Fong et al., Los Angeles, United States. In Mol Vis, 2006
These results indicate that after exon-skipping RGR splice isoform (RGR-d) is synthesized, the RGR-d epitope is released at the basal surface of the retinal pigment epithelium and deposited into Bruch's membrane in human eyes throughout adult life.
A newly discovered visual cycle necessary for vision during continuous illumination.
Review
Wolf, Berkeley, United States. In Nutr Rev, 2002
A protein found in the retinal pigment epithelium named retinal G protein- coupled receptor (RGR) reacts to light in an opposite but parallel way: its prosthetic group, all-trans-retinal, is photoisomerized to 11-cis-retinal.
A photic visual cycle of rhodopsin regeneration is dependent on Rgr.
Impact
Fong et al., Los Angeles, United States. In Nat Genet, 2001
It could be that the retinochrome-like opsins, peropsin, or the retinal G protein-coupled receptor (RGR) opsin12-16 are isomerases in the RPE.
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