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Regulatory factor X, 4

RFX4, regulatory factor X4
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: RFX, RFX5, RFX2, AGE, ACID
Papers on RFX4
Tupaia small RNAs provide insights into function and evolution of RNAi-based transposon defense in mammals.
New
Zischler et al., Mainz, Germany. In Rna, May 2015
Finally, our analyses of tree shrew piRNA clusters indicate A-Myb and the testis-expressed transcription factor RFX4 to be involved in the transcriptional regulation of mammalian piRNA clusters.
RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder.
McMahon et al., Bethesda, United States. In Mol Psychiatry, 2014
DE transcripts include those of serine/arginine-rich splicing factor 5 (SRSF5) and regulatory factor X4 (RFX4), which along with lncRNAs have a role in mammalian circadian rhythms.
Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells.
Okano et al., Tokyo, Japan. In Stem Cells Dev, 2014
Rfx4, which was highly expressed in NS/PCs positive for the Msi1-6IE reporter, bound to this region, and both of the palindromic Rfx binding sites were required for the transactivation of Msi1-6IE.
Whole genome methylation analyses of schizophrenia patients before and after treatment.
Toncheva et al., Sofia, Bulgaria. In Biotechnol Biotechnol Equip, 2014
We found significant differences in the methylation profiles between male schizophrenia patients with complete remission and control male pool before treatment (C16orf70, CST3, DDRGK1, FA2H, FLJ30058, MFSD2B, RFX4, UBE2J1, ZNF311) and male schizophrenia patients with complete remission and control male pool after treatment (AP1S3, C16orf59, KCNK15, LOC146336, MGC16384, XRN2) that potentially could be used as target genes for new therapeutic strategies as well as markers for good treatment response.
RFX7 is required for the formation of cilia in the neural tube.
Kato et al., Tallahassee, United States. In Mech Dev, 2014
RFX7 controlled the formation of cilia by regulating the expression of RFX4 gene, which has been reported to be required for ciliogenesis in the neural tube.
Gene network analyses of first service conception in Brangus heifers: use of genome and trait associations, hypothalamic-transcriptome information, and transcription factors.
Thomas et al., Australia. In J Anim Sci, 2012
There were 5 transcription factors with 21 or more connections: ZMAT3, STAT6, RFX4, PLAGL1, and NR6A1 for FSC.
Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence.
Liu et al., Johnson City, United States. In J Mol Neurosci, 2012
Interestingly, several genes (TESK2, TIPARP, THEMIS, ABLIM1, RFX4, STON2 and LILRA1) are associated with three personality traits with pā€‰<ā€‰10(-3) using single trait analysis and AD.
Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population.
French Parkinson's Disease Genetics Study Group et al., Toulouse, France. In Hum Mol Genet, 2011
The 12q24 locus includes RFX4, an isoform of which, named RFX4_v3, encodes brain-specific transcription factors that regulate many genes involved in brain morphogenesis and intracellular calcium homeostasis.
Differential expression of Rfx1-4 during mouse spermatogenesis.
GeneRIF
Kistler et al., Columbia, United States. In Gene Expr Patterns, 2009
the dominant Rfx4 transcript present begins at a downstream exon and lacks the DNA binding domain
The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.
GeneRIF
Peterson et al., San Francisco, United States. In Sci Signal, 2008
Rfx4 is a regionally specific transcriptional regulator of ciliogenesis and thus is also a regionally specific modulator of Shh signaling during development of the central nervous system.
Transcription factor RFX4 binding to the testis-specific histone H1t promoter in spermatocytes may be important for regulation of H1t gene transcription during spermatogenesis.
Grimes et al., Shreveport, United States. In J Cell Biochem, 2008
The X-box binding protein RFX4 is highly expressed in testis in contrast with other tissues, but its function there is unknown.
Immune transcriptome alterations in the temporal cortex of subjects with autism.
Persico et al., Nashville, United States. In Neurobiol Dis, 2008
Critical expression changes were confirmed by qPCR (BCL6, CHI3L1, CYR61, IFI16, IFITM3, MAP2K3, PTDSR, RFX4, SPP1, RELN, NOTCH2, RIT1, SFN, GADD45B, HSPA6, HSPB8 and SERPINH1).
G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.
GeneRIF
Zeldin et al., United States. In J Biol Chem, 2008
GPS2 interacts with RFX4_v3 to modulate transactivation of genes involved in brain morphogenesis, including Cx3Cl1
Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease.
Review
Blackshear et al., United States. In J Neurosci Res, 2007
Regulatory factor X4 variant 3 (RFX4_v3) is a recently identified transcription factor specifically expressed in the brain.
Identification and characterization of novel human tissue-specific RFX transcription factors.
Chen et al., Canada. In Bmc Evol Biol, 2007
Phylogenetic analysis suggests that the RFX family in the human genome has undergone at least three gene duplications in evolution and the seven human RFX genes can be clearly categorized into three subgroups: (1) RFX1-3, (2) RFX4 and RFX6, and (3) RFX5 and RFX7.
Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4.
GeneRIF
Owen et al., Cardiff, United Kingdom. In Mol Psychiatry, 2005
The gene encoding the transcription factor RFX4 represents an excellent neurobiological and positional candidate gene for Bipolar disorder due to the potential involvement of RFX4 proteins in the regulation of circadian rhythms, linked to chromosome 12.
Restricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus.
GeneRIF
Abe et al., Chiba, Japan. In J Biol Chem, 2004
mouse regulatory factor X4 transcript is expressed in the suprachiasmatic nucleus and regulated by light
Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.
Impact
Burley et al., New York City, United States. In Nature, 2000
Fusions of the ligand-binding domain of the oestrogen receptor with the DBD of RFX4 occur in some human breast tumours.
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