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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulatory factor X, 1

RFX, RFX1, regulatory factor X, EFC, Crt1
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MHC, CAN, CIITA, RFX5, ACID
Papers on RFX
Evaluation of prothrombin time and activated partial thromboplastin time mixing studies using an estimated factor correction method.
Chandler et al., Seattle, United States. In Blood Coagul Fibrinolysis, Jan 2016
We compared this estimated factor correction (EFC) method to normal range, percentage correction, and Rosner index.
Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques.
Apetrei et al., Chicago, United States. In Plos Pathog, Jan 2016
Our goal was to assess the biological and clinical impact of a therapeutic strategy designed to reduce microbial translocation through reduction of the microbial content of the intestine (Rifaximin-RFX) and of gut inflammation (Sulfasalazine-SFZ).
Encapsulated Thyroid Carcinoma of Follicular Cell Origin.
Ghossein et al., New York City, United States. In Endocr Pathol, Sep 2015
This group includes an encapsulated/well-circumscribed (E/WC) follicular variant of papillary carcinoma (FVPTC) and encapsulated follicular and Hurthle cell carcinoma (EFC, EHC respectively).
A Newly-Discovered Mutation in the RFX6 Gene of the Rare Mitchell-Riley Syndrome.
Dandan et al., In J Clin Res Pediatr Endocrinol, Feb 2015
However, the genetic mutation in RFX6 (regulatory factor X on chromosome 6) was only detected in babies who had diabetes, making it different from the previously known mutations for the disease.
RFX transcription factors are essential for hearing in mice.
Hertzano et al., Tel Aviv-Yafo, Israel. In Nat Commun, 2014
We identify RFX transcription factors as essential and evolutionarily conserved regulators of the HC-specific transcriptomes, and detect Rfx1,2,3,5 and 7 in the developing HCs.
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation.
Ehrlich et al., Chicago, United States. In Bmc Cancer, 2014
The DNA regions studied were promoters (BRCA1, CD44, ESR1, GSTM2, GSTP1, MAGEA1, MSI1, NFE2L3, RASSF1A, RUNX3, SIX3 and TFF1), far-upstream regions (EN1, PAX3, PITX2, and SGK1), introns (APC, EGFR, LHX2, RFX1 and SOX9) and the LINE-1 and satellite 2 DNA repeats.
[Transcriptional control of ciliary genes].
Durand et al., Villeurbanne, France. In Med Sci (paris), 2014
At least two classes of transcription factors are involved in ciliogenesis: the RFX family, essential for the assembly of most cilia and the FOXJ1 transcription factors that are key regulators of motile cilia assembly.
MHC class I and II deficiencies.
Etzioni et al., Haifa, Israel. In J Allergy Clin Immunol, 2014
These transacting factors are the class II transactivator and 3 subunits of regulatory factor X (RFX): RFX containing ankyrin repeats (RFXANK), the fifth member of the RFX family (RFX5), and RFX-associated protein (RFXAP).
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.
Walsh et al., Boston, United States. In Science, 2014
Here, we describe a 15-base pair deletion mutation in a regulatory element of GPR56 that selectively disrupts human cortex surrounding the Sylvian fissure bilaterally including "Broca's area," the primary language area, by disrupting regional GPR56 expression and blocking RFX transcription factor binding.
Expression regulation and function of NLRC5.
Qian et al., Shanghai, China. In Protein Cell, 2013
The expression of MHC class I genes is regulated by NLRC5 in coordination with the RFX components through an enhanceosome-dependent manner.
Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus.
Lu et al., Changsha, China. In J Autoimmun, 2013
On the other hand, certain miRNAs, RFX1, defective ERK pathway signaling, Gadd45α and DNA hydroxymethylation have been proposed as potential mechanisms leading to DNA hypomethylation in lupus.
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.
Vermeulen et al., Utrecht, Netherlands. In Cell, 2013
Readers for these modifications are only partially overlapping, and some readers, such as Rfx proteins, display strong specificity.
Ciliogenic RFX transcription factors regulate FGF1 gene promoter.
Chiu et al., Taiwan. In J Cell Biochem, 2012
Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs.
Regulatory factor X1-induced down-regulation of transforming growth factor β2 transcription in human neuroblastoma cells.
Zuo et al., Charlottesville, United States. In J Biol Chem, 2012
RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription.
Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization.
Jarman et al., Edinburgh, United Kingdom. In Dev Cell, 2012
It was shown that fd3F is required for specialization of the mechanosensory cilium of chordotonal neurons. Fd3F cooperates with the panciliary transcription factor, Rfx, to regulate its targets directly.
NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression.
Kobayashi et al., Boston, United States. In J Immunol, 2012
NLRC5-mediated histocompatibiility class I gene induction requires the W/S and X1, X2 cis-regulatory elements.
Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development.
Zaret et al., Philadelphia, United States. In Plos Genet, 2011
Rfx1 could be an indicator of progression from Barrett's esophagus to adenocarcinoma.
Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.
Katsanis et al., Baltimore, United States. In Nature, 2003
Finally, we demonstrate that all available Caenorhabditis elegans BBS homologues are expressed exclusively in ciliated neurons, and contain regulatory elements for RFX, a transcription factor that modulates the expression of genes associated with ciliogenesis and intraflagellar transport.
Chromatin remodeling and extragenic transcription at the MHC class II locus control region.
Reith et al., Genève, Switzerland. In Nat Immunol, 2003
We show here that this LCR is bound by the MHC class II-specific transactivators regulatory factor X (RFX) and class II transactivator (CIITA).
Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome.
Peterlin et al., San Francisco, United States. In Nat Immunol, 2002
Its wild-type counterpart restored binding of the RFX complex to DNA, transcription of all MHC class II genes and the appearance of these determinants on the surface of BLS cells.
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