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RFC5 Rfc5p

RFC5, Rfc5p
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: RFC3, POLYMERASE, Ctf18, Rad17, PCNA
Papers on RFC5
Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer.
Gao et al., Wuhan, China. In Int J Oncol, 2014
The increase of SIX1 expression resulted in the upregulation of multiple genes related to the initiation of DNA replication, including the genes coding for the proteins in minichromosome maintenance complex (MCM2, MCM3, MCM6), DNA polymerase α-primase complex (POLA1, PRIM1, PRIM2), clamp loader (RFC3, RFC4, RFC5), DNA polymerase δ complex (POLD3) and DNA polymerase ε complex (POLE2).
Distinguishing between cancer cell differentiation and resistance induced by all-trans retinoic acid using transcriptional profiles and functional pathway analysis.
Wang et al., Wuhan, China. In Sci Rep, 2013
Transcriptional profiles and functional pathway analyses further demonstrated that 7 genes (FEN1, RFC5, EXO1, XRCC5, PARP1, POLR2F, and GTF2H3) that were relatively up-regulated in HL-60[R] cells and repressed in cells with ATRA-induced differentiation were related to mismatch repair in eukaryotes, DNA double-strand break repair, and nucleotide excision repair pathways.
Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia.
Hong et al., Rochester, United States. In Cancer Prev Res (phila), 2011
DFMO downregulated Krüppel-like factor 5 (KLF5), a transcription factor promoting cell proliferation, and suppressed RFC5 whose protein interacts with proliferating cell nuclear antigen.
Rfc5p regulates alternate RFC complex functions in sister chromatid pairing reactions in budding yeast.
Skibbens et al., Bethlehem, United States. In Cell Cycle, 2010
A novel and critical role for the small RFC subunit Rfc5p promotes anti-establishment activities.
Epitope tag-induced synthetic lethality between cohesin subunits and Ctf7/Eco1 acetyltransferase.
Skibbens et al., Bethlehem, United States. In Febs Lett, 2010
We further demonstrate that mutation in ELG1 or RFC5 anti-establishment genes suppress tag-induced lethality, consistent with the notion that the replication fork regulates Ctf7/Eco1.
Isolated hepatic perfusion with high-dose melphalan results in immediate alterations in tumor gene expression in patients with metastatic ocular melanoma.
Alexander et al., Baltimore, United States. In Ann Surg Oncol, 2010
In post-IHP samples the overexpression of a DNA replication associated gene, replication factor C (RFC5), was significantly associated with shortened survival (P < 0.003).
The Elg1-RFC clamp-loading complex performs a role in sister chromatid cohesion.
Skibbens et al., Bethlehem, United States. In Plos One, 2008
It is widely accepted that of the four Replication Factor C (RFC) complexes (defined by the associations of either Rfc1p, Ctf18p, Elg1p or Rad24p with Rfc2p-Rfc5p), only Ctf18-RFC functions in sister chromatid cohesion.
Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas.
Khan et al., Pittsburgh, United States. In Eur J Cancer, 2007
Such upregulated genes included those involved in nuclear structure and meiosis (SYCP2), DNA repair (RFC5), and transcription regulation (ZNF238).
The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading.
O'Donnell et al., New York City, United States. In J Biol Chem, 2006
RFC consists of five subunits in a spiral arrangement (RFC-A, -B, -C, -D, and -E, corresponding to subunits RFC1, RFC4, RFC3, RFC2, and RFC5, respectively).
Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast.
MacNeill et al., Edinburgh, United Kingdom. In Nucleic Acids Res, 2004
Cells carrying a temperature-sensitive mutation in the CTD, rfc1-44, arrest with incompletely replicated chromosomes, are sensitive to DNA damaging agents, are synthetically lethal with other DNA replication mutants, and can be suppressed by mutations in rfc5.
Rad18/Rad5/Mms2-mediated polyubiquitination of PCNA is implicated in replication completion during replication stress.
Enomoto et al., Sendai, Japan. In Genes Cells, 2004
Multicopy PCNA alleviated the replication defects of rfc5-1 strains, but not those of poldelta mutants.
Mechanical link between cohesion establishment and DNA replication: Ctf7p/Eco1p, a cohesion establishment factor, associates with three different replication factor C complexes.
Skibbens et al., Bethlehem, United States. In Mol Cell Biol, 2003
Chl12p/Ctf18p combines with Rfc2p to Rfc5p to form one of three independent RFC complexes.
The product of Saccharomyces cerevisiae WHIP/MGS1, a gene related to replication factor C genes, interacts functionally with DNA polymerase delta.
Enomoto et al., Sendai, Japan. In Mol Genet Genomics, 2002
Moreover, loss of MGS1 function interferes with the ability of multicopy PCNA to suppress the replication defect of the rfc5-1 mutant.
Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process.
Thelen et al., Livermore, United States. In Protein Sci, 2002
Additional sequence and structure analysis, supported by experimental data, suggests that RFC5 might be the third clamp loader subunit to bind the equivalent PCNA region.
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae.
Kolodner et al., San Diego, United States. In Cell, 2001
Mutations in Saccharomyces cerevisiae RFC5, DPB11, MEC1, DDC2 MEC3, RAD53, CHK1, PDS1, and DUN1 increased the rate of genome rearrangements up to 200-fold whereas mutations in RAD9, RAD17, RAD24, BUB3, and MAD3 had little effect.
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