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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RFC3 Rfc3p

RFC3, Rfc3p
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, PCNA, POLYMERASE, RFC5, V1a
Papers on RFC3
The rice DUF1620-containing and WD40-like repeat protein is required for the assembly of the restoration of fertility complex.
Hu et al., Wuhan, China. In New Phytol, Feb 2016
Here, we identified RFC subunit 3, which encodes a DUF1620-containing and WD40-like repeat protein (RFC3) that is present in all tissues but highly expressed in leaves.
shRNA-mediated silencing of the RFC3 gene suppresses hepatocellular carcinoma cell proliferation.
Liu et al., Guangzhou, China. In Int J Mol Med, Nov 2015
The role of RFC3 in the development of HCC is, as of yet, not fully understood.
Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA.
Sakamoto et al., Stanford, United States. In Leukemia, Jun 2015
Replication factor C3 (RFC3) is required for chromatin loading of proliferating cell nuclear antigen (PCNA) which is a sliding clamp platform for recruiting numerous proteins in the DNA metabolism.
Exploring potential new floral organ morphogenesis genes of Arabidopsis thaliana using systems biology approach.
He et al., Guangzhou, China. In Front Plant Sci, 2014
It possibly formed a complex between RFC3 and RPS15 in cytoplasm, which regulated TSO1 and CPSF160 in the nucleus, to control the floral organ morphogenesis.
ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation.
Jiang et al., Guangzhou, China. In Int J Clin Exp Pathol, 2014
Replication factor C (RFC) plays an important role in DNA replication, DNA damage repair, and checkpoint control during cell cycle progression in all eukaryotes.
Identification of a subset of patients with acute myeloid leukemia characterized by long-term in vitro proliferation and altered cell cycle regulation of the leukemic cells.
Bruserud et al., Bergen, Norway. In Expert Opin Ther Targets, 2014
Patients with long-term proliferation showed altered expression in six cell cycle-related genes (HMMR, BUB1, NUSAP1, AURKB, CCNF, DLGAP5), two genes involved in DNA replication (TOP2A, RFC3) and one gene with unknown function (LHFPL2).
Overexpression of RFC3 is correlated with ovarian tumor development and poor prognosis.
Jiang et al., Guangzhou, China. In Tumour Biol, 2014
Replication factor C3 (RFC3) is an oncogene that can potentially predict prognosis in a variety of human cancers.
Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer.
Gao et al., Wuhan, China. In Int J Oncol, 2014
The increase of SIX1 expression resulted in the upregulation of multiple genes related to the initiation of DNA replication, including the genes coding for the proteins in minichromosome maintenance complex (MCM2, MCM3, MCM6), DNA polymerase α-primase complex (POLA1, PRIM1, PRIM2), clamp loader (RFC3, RFC4, RFC5), DNA polymerase δ complex (POLD3) and DNA polymerase ε complex (POLE2).
Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.
Barbour et al., Brisbane, Australia. In Nat Commun, 2013
WGS of 22 EAC cases show that catastrophes may lead to oncogene amplification through chromothripsis-derived double-minute chromosome formation (MYC and MDM2) or breakage-fusion-bridge (KRAS, MDM2 and RFC3).
9-Cis-retinoic acid induces growth inhibition in retinoid-sensitive breast cancer and sea urchin embryonic cells via retinoid X receptor α and replication factor C3.
Sohn et al., Kangnŭng, South Korea. In Mol Endocrinol, 2012
Here, we provide evidence that the inhibitory effect of 9-cis-RA on cell proliferation depends on 9-cis-RA-dependent interaction of retinoid X receptor α (RXRα) with replication factor C3 (RFC3), which is a subunit of the RFC heteropentamer that opens and closes the circular proliferating cell nuclear antigen (PCNA) clamp on DNA.
Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma.
Beer et al., Vancouver, Canada. In Clin Cancer Res, 2012
Data identified RFC3 as a candidate oncogene amplified in esophageal adenocarcinoma (EAC).
Interaction of C60 fullerene with the proteins involved in DNA mismatch repair pathway.
Dhawan et al., Lucknow, India. In J Biomed Nanotechnol, 2011
Significant interactions of fullerene with PMS2, RFC3 and PCNA proteins were observed.
Mutational and expressional analysis of RFC3, a clamp loader in DNA replication, in gastric and colorectal cancers.
Yoo et al., Seoul, South Korea. In Hum Pathol, 2010
RFC3 mutation and loss of RFC3 expression occur in large fractions of gastric and colorectal cancers and suggest that these alterations may contribute to the cancer pathogenesis by deregulating DNA repair and replication.
Production of Pectate Lyase by Penicillium viridicatum RFC3 in Solid-State and Submerged Fermentation.
Gomes et al., Ribeirão Preto, Brazil. In Int J Microbiol, 2009
Pectate lyase (PL) was produced by the filamentous fungus Penicillium viridicatum RFC3 in solid-state cultures of a mixture of orange bagasse and wheat bran (1 : 1 w/w), or orange bagasse, wheat bran and sugarcane bagasse (1 : 1 : 0.5 w/w), and in a submerged liquid culture with orange bagasse and wheat bran (3%) as the carbon source.
Purification of an Exopolygalacturonase from Penicillium viridicatum RFC3 Produced in Submerged Fermentation.
Silva et al., Ribeirão Preto, Brazil. In Int J Microbiol, 2008
An exo-PG obtained from Penicillium viridicatum in submerged fermentation was purified to homogeneity.
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