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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

REV3 Rev3p

REV3, DNA polymerase zeta, pso1
Top mentioned proteins: POLYMERASE, Rev1, CAN, FUS, REV7
Papers on REV3
Cytotoxic and genotoxic profiles of benzo[a]pyrene and N-nitrosodimethylamine demonstrated using DNA repair deficient DT40 cells with metabolic activation.
Hirota et al., Hachiōji, Japan. In Chemosphere, Feb 2016
The REV3(-/-) mutant cell line exhibited the highest sensitivity, in terms of increased cytotoxicity, to the both compounds after metabolic activation consistent with the known ability of these two compounds to induce DNA adducts.
Subtype-selective Nicotinic Acetylcholine Receptor agonists can improve Cognitive Flexibility in an Attentional Set Shifting Task.
Shoaib et al., Newcastle, South Africa. In Neuropharmacology, Feb 2016
All compounds except for PNU-120596 were observed to significantly improve extra-dimensional (ED) shift performance, nicotine, 5IA-85380 and SSR180711 further enhanced the final reversal (REV3) stage of the task.
MAT- gene structure and mating behavior of Hymenoscyphus fraxineus and Hymenoscyphus albidus.
Gross et al., Zürich, Switzerland. In Fungal Genet Biol, Jan 2016
Furthermore, we present the complete mating type 1-1 locus of H. fraxineus and report the finding of three additional genes within this region; the as yet unobserved typical mating type gene MAT1-1-1, a DNA polymerase zeta catalytic subunit and a pre-mRNA-splicing factor SLU7.
The Translesion Polymerase ζ Has Roles Dependent on and Independent of the Nuclease MUS81 and the Helicase RECQ4A in DNA Damage Repair in Arabidopsis.
Puchta et al., Karlsruhe, Germany. In Plant Physiol, Dec 2015
DNA polymerase zeta catalytic subunit REV3 is known to play an important role in the repair of DNA damage induced by cross-linking and methylating agents.
Discrete lineages within Alternaria alternata species group: Identification using new highly variable loci and support from morphological characters.
Clarkson et al., Luton, United Kingdom. In Fungal Biol, Nov 2015
These loci included three new phylogenetic loci (TMA22, PGS1, and REV3) identified as highly variable based on publically available genome sequence data for Dothideomycete species.
MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection.
Jacobs et al., Amsterdam, Netherlands. In Nature, Jun 2015
These activities of MAD2L2 depend on ATM kinase activity, RNF8, RNF168, 53BP1 and RIF1, but not on PTIP, REV1 and REV3, the latter two acting with MAD2L2 in translesion synthesis.
REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.
Canman et al., Ann Arbor, United States. In Environ Mol Mutagen, 2012
It is now well recognized that translesion DNA synthesis (TLS), especially through the activities of REV1 and DNA polymerase zeta (Polζ), is necessary for both ICL repair pathways operating throughout the cell cycle.
Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis.
Hashimoto et al., Yokohama, Japan. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment has been crystallized. The crystals belonged to space group P3(1)21, with unit-cell parameters a = b = 74.7, c = 124.5 A
Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity.
Diaz et al., United States. In J Immunol, 2012
DNA polymerase zeta transgene participates directly in immunoglobulin hypermutation.
The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.
Moriya et al., Stony Brook, United States. In J Biol Chem, 2012
REV7 subunit of pol zeta mediated the interaction between REV3 and the REV1 C terminus.
REV1 and polymerase ζ facilitate homologous recombination repair.
Canman et al., Ann Arbor, United States. In Nucleic Acids Res, 2012
The REV1/Polzeta complex maintains genomic stability by directly participating in DNA double-stranded break repair.
Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells.
Marti et al., Zürich, Switzerland. In Neoplasia, 2011
Findings indicate that depletion of REV3 not only can amend cisplatin-based cancer therapy but also can be applied for susceptible cancers as a potential monotherapy.
Mechanism of replication-coupled DNA interstrand crosslink repair.
Walter et al., Boston, United States. In Cell, 2008
Immunodepletion experiments suggest that extension requires DNA polymerase zeta.
DNA polymerase zeta (pol zeta) in higher eukaryotes.
Wood et al., Pittsburgh, United States. In Cell Res, 2008
Most current knowledge about DNA polymerase zeta (pol zeta) comes from studies of the enzyme in the budding yeast Saccharomyces cerevisiae, where pol zeta consists of a complex of the catalytic subunit Rev3 with Rev7, which associates with Rev1.
Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae.
Henriques et al., Porto Alegre, Brazil. In Mutat Res, 2003
Of the seven DNA repair genes involved in induced mutagenesis three PSO loci [PSO1/REV3, PSO8/RAD6, PSO9/MEC3] were allelic to already known repair genes, whereas three, PSO2/SNM1, PSO3/RNR4, and PSO4/PRP19 represent new genes involved in DNA repair and nucleic acid metabolism in S. cerevisiae.
DNA polymerase zeta: new insight into eukaryotic mutagenesis and mammalian embryonic development.
Zhang et al., Hangzhou, China. In World J Gastroenterol, 2003
DNA polymerase zeta (pol zeta), which was found firstly in budding yeast Saccharomyces cerevisiae and consists of catalytic subunit scRev3 and stimulating subunit scRev7, has received more attention in recent years.
DNA damage-induced mutagenesis : a novel target for cancer prevention.
Wang, Lexington, United States. In Mol Interv, 2001
Error-prone lesion bypass constitutes a major mechanism of mutagenesis and, in eukaryotes, is primarily effected by the DNA polymerase zeta (Polzeta) pathway.
The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.
Casali et al., New York City, United States. In Immunity, 2001
Inhibition of the pol zeta REV3 catalytic subunit by specific phosphorothioate-modified oligonucleotides impaired Ig and bcl-6 hypermutation and UV damage-induced DNA mutagenesis, without affecting cell cycle or viability.
Deoxycytidyl transferase activity of yeast REV1 protein.
Hinkle et al., Rochester, United States. In Nature, 1996
Mutagenesis induced by DNA damage in Saccharomyces cerevisiae requires the products of the REV1, REV3 and REV7 genes.
Thymine-thymine dimer bypass by yeast DNA polymerase zeta.
Hinkle et al., Rochester, United States. In Science, 1996
The Rev3-Rev7 complex is the sixth eukaryotic DNA polymerase to be described, and is therefore called DNA polymerase zeta.
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