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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Retinoid X receptor, alpha

retinoid X receptor alpha, retinoid X receptor beta, RXRB, RXRA
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, PPAR, RAR, CIs
Papers on retinoid X receptor alpha
RXRα, PXR and CAR xenobiotic receptors mediate the apoptotic and neurotoxic actions of nonylphenol in mouse hippocampal cells.
Kajta et al., Kraków, Poland. In J Steroid Biochem Mol Biol, Feb 2016
In the present study, we investigated the role of the retinoid X receptor (RXR), the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), in the apoptotic and toxic effects of nonylphenol in mouse primary neuronal cell cultures.
Hypothyroidism Side Effect in Patients Treated with Sunitinib or Sorafenib: Clinical and Structural Analyses.
Lin et al., Chongqing, China. In Plos One, Dec 2015
Then, we used docking method and identified 3 proteins specifically binding to sunitinib but not sorafenib, i.e., retinoid X receptor alpha, retinoic acid receptors beta and gamma.
De novo 9q gain in an infant with tetralogy of Fallot with absent pulmonary valve: Patient report and review of congenital heart disease in 9q duplication syndrome.
Wambach et al., Saint Louis, United States. In Am J Med Genet A, Dec 2015
This duplicated interval disrupted RXRA (retinoid X receptor alpha; OMIM #180245) at intron 1.
Genetic Variants in the Vitamin D Pathway Genes VDBP and RXRA Modulate Cutaneous Melanoma Disease-Specific Survival.
Wei et al., Suzhou, China. In Pigment Cell Melanoma Res, Dec 2015
and the same for RXRA rs7850212 C>A (combined HR=0.38), which were further confirmed by the Fine and Gray competing risks regression model.
Effects of Low-Dose Diethylstilbestrol Exposure on DNA Methylation in Mouse Spermatocytes.
Liu et al., Chongqing, China. In Plos One, 2014
Rxra, an important component of the retinoic acid signaling pathway, and mybph, a RhoA pathway-related protein, were found to be hypermethylated, and Prkcd, an apoptosis-related protein, was hypomethylated.
Association of Retinoid X Receptor Alpha Gene Polymorphism with Clinical Course of Chronic Glomerulonephritis.
Jagodziński et al., Poznań, Poland. In Med Sci Monit, 2014
MATERIAL AND METHODS GFR category 1-3 ChGN patients (n=195), GFR category 5D ChGN patients (n=178), and controls (n=751) underwent testing for polymorphisms of genes encoding VD binding protein (GC, rs2298849, rs7041, rs1155563), VDR (VDR, rs2228570, rs1544410), and retinoid X receptor alpha (RXRA, rs10776909, rs10881578, rs749759).
RARA fusion genes in acute promyelocytic leukemia: a review.
De Braekeleer et al., Brest, France. In Expert Rev Hematol, 2014
The resulting fusion proteins retain domains of the RARA protein allowing binding to retinoic acid response elements (RARE) and dimerization with the retinoid X receptor protein (RXRA).
An emerging role for retinoid X receptor α in malignant hematopoiesis.
Kamel-Reid et al., Toronto, Canada. In Leuk Res, 2012
Highlight of recent studies that clarify the role of RXR alpha in normal and malignant hematopoiesis.
Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis.
Strick et al., Erlangen, Germany. In J Cell Biochem, 2012
proposed that Syncytin-1 is regulated by PPARgamma/RXRalpha signaling during placentogenesis to drive multinuclear syncytiotrophoblast layer formation and maintenance.
Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers.
Fernandez et al., Knoxville, United States. In Proc Natl Acad Sci U S A, 2012
Data show a structural basis for allosteric communication between 3,3',5 triiodo-L-thyronine (T3) and 9-cis retinoic acid receptor (RXR) and negative cooperativity between their binding pockets.
Retinoid X receptor alpha (RXRα) and peroxisome proliferator-activated receptor gamma (PPARγ) expression in breast cancer: an immunohistochemical study.
Jeschke et al., München, Germany. In In Vivo, 2012
Data show that RXRalpha was strongly and moderately expressed in 11 (14.10%) and 33 (42.31%) cases, respectively, and PPARgamma was strongly and moderately expressed in 33 (41.25%) and 25 (31.25%) cases, respectively.
Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.
Kida et al., Tokyo, Japan. In Mol Brain, 2011
The expression of dominant-negative RAR (dnRAR) in the forebrain down-regulated the expression of RARbeta, a target gene of RAR/RXR, indicating that dnRAR mice exhibit dysfunction of the RAR/RXR signaling pathway.
[RXR, a key member of the oncogenic complex in acute promyelocytic leukemia].
De Thé et al., Paris, France. In Med Sci (paris), 2011
RXRa is required for rexinoid-induced acute promyelocytic leukemia; thus RXRa is a key member of the oncogenic complex.
Granuloma formation in ANCA-associated vasculitides.
Kallenberg et al., Lübeck, Germany. In Apmis Suppl, 2009
The HLA-DPB1/RING1/RXRB region constitutes a quantitative trait locus for ANCA-positive WG with the strongest association to be reported up to now.
[Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis].
Bartosz et al., Łódź, Poland. In Postepy Hig Med Dosw (online), 2008
Although the mechanisms of the regulation of seladin-1 activity demand further elucidation, it has already been shown that DHCR24 gene was activated byLXRa/RXRa in skin, by ERa in neurons, and by AR in prostate.
RXR is an essential component of the oncogenic PML/RARA complex in vivo.
de Thé et al., Paris, France. In Cancer Cell, 2007
Although PML-enforced RARA homodimerization allows PML/RARA to bind DNA independently of its coreceptor RXR, the latter was identified within the PML/RARA complex.
Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta.
Noda et al., Tokyo, Japan. In Nat Genet, 2004
The testicular phenotypes of Cnot7(-/-) mice are similar to those of mice deficient in retinoid X receptor beta (Rxrb).
Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding.
Evans et al., Los Angeles, United States. In Science, 1993
The three-dimensional solution structure of the DNA binding domain (DBD) of the retinoid X receptor alpha (RXR alpha) was determined by nuclear magnetic resonance spectroscopy.
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
Mader et al., Strasbourg, France. In Cell, 1992
The purified protein is a human retinoid X receptor beta (hRXR beta).
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