gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

RE1-silencing transcription factor

REST, NRSF, neuron-restrictive silencer factor
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: CAN, Histone, V1a, CoREST, ACID
Papers on REST
REST and stress resistance in ageing and Alzheimer's disease.
New
Impact
Yankner et al., Boston, United States. In Nature, 27 Apr 2014
Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuron-restrictive silencer factor, NRSF) is a universal feature of normal ageing in human cortical and hippocampal neurons.
REST is Present in Human Control and Huntington's Disease Neurons.
New
Zuccato et al., Pavia, Italy. In Neuropathol Appl Neurobiol, 17 Apr 2014
AIMS: The repressor element-1 silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a master regulator of neuronal gene expression.
EFFECTS OF DIFFERENT REST INTERVALS BETWEEN ANTAGONIST PAIRED SETS ON REPETITION PERFOMANCE AND MUSCLE ACTIVATION.
New
Miranda et al., Charleston, United States. In J Strength Cond Res, 11 Apr 2014
The purpose of the current study was to examine the effects of different rest intervals between sets for exercises that involve antagonistic muscle groups; a technique referred to as antagonist paired sets (APS).
Consuming a Western diet for two weeks suppresses fetal genes in mouse hearts.
New
Marsh et al., Washington, D.C., United States. In Am J Physiol Regul Integr Comp Physiol, 12 Mar 2014
Hypertrophy is regulated at chromatin by repressor element 1-silencing transcription factor (REST), and pathological hypertrophy is associated with reexpression of a fetal cardiac gene program.
Autophagy Pathway Is Required for IL-6 Induced Neuroendocrine Differentiation and Chemoresistance of Prostate Cancer LNCaP Cells.
New
Kung et al., Davis, United States. In Plos One, Dec 2013
Most important to this study is the discovery of REST, a neuronal gene-specific transcriptional repressor that is involved in autophagy activation.
Effect of Age on Complexity and Causality of the Cardiovascular Control: Comparison between Model-Based and Model-Free Approaches.
New
Catai et al., Milano, Italy. In Plos One, Dec 2013
The framework was applied to study age-related modifications of complexity and causality in healthy humans in supine resting (REST) and during standing (STAND).
Expression and function of the dense-core vesicle membranes are governed by the transcription repressor REST.
Review
New
Meldolesi et al., Castellana Grotte, Italy. In Febs Lett, Jul 2013
REST, the transcription repressor expressed at high levels in non-neural and at very low levels in neural cells, was found to regulate the genes encoding almost all the proteins of both the core and the membrane of the dense-core vesicles, including the transporter for catecholamines and the SNAREs for their exocytosis.
REST: an oncogene or a tumor suppressor?
Review
New
Meldolesi et al., Milano, Italy. In Trends Cell Biol, Jun 2013
The Repressor Element-1 (RE-1) Silencing Transcription (REST) factor, which is highly expressed in stem cells and non-neural cells, with low expression in neurons and other neural cells, orchestrates neural differentiation and preserves the unique neural phenotype.
The role of the CoREST/REST repressor complex in herpes simplex virus 1 productive infection and in latency.
Review
New
Roizman et al., Chicago, United States. In Viruses, May 2013
REST is a key component of the HDAC1 or 2, CoREST, LSD1, REST (HCLR) repressor complex.
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
New
Impact
Fu et al., Wuhan, China. In Cell, Feb 2013
A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells.
Epigenetics and epilepsy.
Review
Hsieh et al., Madison, United States. In Epilepsia, 2012
One transcription factor in particular, repressor element 1-silencing transcription factor (REST), has received a lot of attention due to the possibility that it may control fundamental transcription patterns that drive circuit excitability, seizures, and epilepsy.
Multiple Aspects of Gene Dysregulation in Huntington's Disease.
Review
Caboche et al., Paris, France. In Front Neurol, 2012
Another key mechanism described so far, is an alteration of cytoplasmic retention of the transcriptional repressor REST, which is normally associated with wild-type Htt.
Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.
Impact
Walsh et al., Boston, United States. In Cell, 2012
ZNF335 is a component of a vertebrate-specific, trithorax H3K4-methylation complex, directly regulating REST/NRSF, a master regulator of neural gene expression and cell fate, as well as other essential neural-specific genes.
REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells.
GeneRIF
Ballas et al., Stony Brook, United States. In Development, 2012
central role for REST during neural development in promoting neural stem/progenitor cell self-renewal while restricting the generation and maturation of neurons and oligodendrocytes
Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors.
GeneRIF
Roopra et al., Madison, United States. In Cancer Res, 2012
findings therefore show a critical role for the REST-LIN28A axis in tumor aggression and suggest a causative relationship between REST loss and tumorigenicity in vivo
The joint association of REST and NFKB1 polymorphisms on the risk of colorectal cancer.
GeneRIF
Chen et al., Hangzhou, China. In Ann Hum Genet, 2012
the present study found that mutation in the REST gene rather than the NFKB1 gene was associated with the risk of CRC.
Ubiquitination and deubiquitination of REST and its roles in cancers.
Review
GeneRIF
Bao et al., Cleveland, United States. In Febs Lett, 2012
role of REST in cancers
REST controls self-renewal and tumorigenic competence of human glioblastoma cells.
GeneRIF
Cattaneo et al., Milano, Italy. In Plos One, 2011
REST controls self-renewal and tumorigenic competence of human glioblastoma cells.
Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.
Impact
GeneRIF
Bao et al., Cleveland, United States. In Nat Cell Biol, 2011
These data demonstrate that HAUSP stabilizes REST through deubiquitylation and antagonizes beta-TrCP in regulating REST at the post-translational level.
Can controversies be put to REST?
Impact
Fisher et al., London, United Kingdom. In Nature, 2010
The contribution of REST to embryonic stem (ES) cell pluripotency has been uncertain.
share on facebooktweetadd +1mail to friends