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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

RE1-silencing transcription factor

REST, NRSF, neuron-restrictive silencer factor
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: CAN, Histone, V1a, CoREST, ACID
Papers on REST
OCT-4 and DAZL expression in precancerous lesions of the human uterine cervix.
New
Loutradis et al., Athens, Greece. In J Obstet Gynaecol Res, 10 Jan 2015
We used REST for statistical analysis of real-time PCR.
NRSF: an Angel or a Devil in Neurogenesis and Neurological Diseases.
New
Yang et al., Beijing, China. In J Mol Neurosci, 06 Jan 2015
UNLABELLED: The neuron-restrictive silencer factor (NRSF) a transcriptional regulator that function as a hub that coordinately regulates multiple aspects of neurogenesis, orchestrates neural differentiation, and preserves the unique neural phenotype.
Molecular Mechanisms Regulating the Defects in Fragile X Syndrome Neurons Derived from Human Pluripotent Stem Cells.
New
Benvenisty et al., Jerusalem, Israel. In Stem Cell Reports, 03 Jan 2015
Our data revealed aberrant regulation of neural differentiation and axon guidance genes in FXS-derived neurons, which are regulated by the RE-1 silencing transcription factor (REST).
347 could the differential expression of luteinizing hormone receptor isoforms explain the variability in superovulatory responses in cattle?
New
Viana et al., Juiz de Fora, Brazil. In Reprod Fertil Dev, 31 Dec 2014
Analyses were performed using the REST software and the expression values are shown as mean ± s.e.m.
49 effects of dietary conjugated linoleic Acid supplementation on bovine oocyte lipid metabolism, lipid composition, and embryo cryotolerance.
New
Godke et al., Baton Rouge, United States. In Reprod Fertil Dev, 31 Dec 2014
Relative gene expression of COC was evaluated using the REST 2009 Software.
REST and stress resistance in ageing and Alzheimer's disease.
New
Impact
Yankner et al., Boston, United States. In Nature, Apr 2014
Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuron-restrictive silencer factor, NRSF) is a universal feature of normal ageing in human cortical and hippocampal neurons.
HOTAIR: a cancer-related long non-coding RNA.
Review
New
Zhang et al., In Neoplasma, Dec 2013
Recent studies revealed HOX transcript antisense RNA, a lncRNA with regulatory functions of transcription, could bind PRC2 and LSD1/CoREST/REST complexes and direct to the specific gene sites, resulted in H3K27 methylation and H3K4 demethylation and ultimately gene silencing.
Expression and function of the dense-core vesicle membranes are governed by the transcription repressor REST.
Review
New
Meldolesi et al., Castellana Grotte, Italy. In Febs Lett, Jul 2013
REST, the transcription repressor expressed at high levels in non-neural and at very low levels in neural cells, was found to regulate the genes encoding almost all the proteins of both the core and the membrane of the dense-core vesicles, including the transporter for catecholamines and the SNAREs for their exocytosis.
The role of the CoREST/REST repressor complex in herpes simplex virus 1 productive infection and in latency.
Review
New
Roizman et al., Chicago, United States. In Viruses, May 2013
REST is a key component of the HDAC1 or 2, CoREST, LSD1, REST (HCLR) repressor complex.
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.
New
Impact
Fu et al., Wuhan, China. In Cell, Feb 2013
A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells.
Multiple Aspects of Gene Dysregulation in Huntington's Disease.
Review
Caboche et al., Paris, France. In Front Neurol, 2012
Another key mechanism described so far, is an alteration of cytoplasmic retention of the transcriptional repressor REST, which is normally associated with wild-type Htt.
Role of NRSF/REST in the regulation of cardiac gene expression and function.
Review
Kuwahara, Kyoto, Japan. In Circ J, 2012
Investigation of the transcriptional regulation of cardiac genes revealed a transcriptional repressor, neuron-restrictive silencer factor (NRSF), also called repressor element-1 silencing factor (REST), to be an important regulator of multiple fetal cardiac genes.
Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.
Impact
Walsh et al., Boston, United States. In Cell, 2012
ZNF335 is a component of a vertebrate-specific, trithorax H3K4-methylation complex, directly regulating REST/NRSF, a master regulator of neural gene expression and cell fate, as well as other essential neural-specific genes.
REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells.
GeneRIF
Ballas et al., Stony Brook, United States. In Development, 2012
central role for REST during neural development in promoting neural stem/progenitor cell self-renewal while restricting the generation and maturation of neurons and oligodendrocytes
Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors.
GeneRIF
Roopra et al., Madison, United States. In Cancer Res, 2012
findings therefore show a critical role for the REST-LIN28A axis in tumor aggression and suggest a causative relationship between REST loss and tumorigenicity in vivo
The joint association of REST and NFKB1 polymorphisms on the risk of colorectal cancer.
GeneRIF
Chen et al., Hangzhou, China. In Ann Hum Genet, 2012
the present study found that mutation in the REST gene rather than the NFKB1 gene was associated with the risk of CRC.
Ubiquitination and deubiquitination of REST and its roles in cancers.
Review
GeneRIF
Bao et al., Cleveland, United States. In Febs Lett, 2012
role of REST in cancers
REST controls self-renewal and tumorigenic competence of human glioblastoma cells.
GeneRIF
Cattaneo et al., Milano, Italy. In Plos One, 2011
REST controls self-renewal and tumorigenic competence of human glioblastoma cells.
Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.
Impact
GeneRIF
Bao et al., Cleveland, United States. In Nat Cell Biol, 2011
These data demonstrate that HAUSP stabilizes REST through deubiquitylation and antagonizes beta-TrCP in regulating REST at the post-translational level.
Can controversies be put to REST?
Impact
Fisher et al., London, United Kingdom. In Nature, 2010
The contribution of REST to embryonic stem (ES) cell pluripotency has been uncertain.
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