Give it a REST!
Edinburgh, United Kingdom. In Elife, 31 Dec 2015
The REST protein helps to prevent the premature activation of genes that are only expressed in mature neurons, and is now found to protect the genome of neural progenitor cells.
REST and stress resistance in ageing and Alzheimer's disease.
Boston, United States. In Nature, 2014
Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuron-restrictive silencer factor, NRSF) is a universal feature of normal ageing in human cortical and hippocampal neurons.