REST represses a subset of the pancreatic endocrine differentiation program.
Lausanne, Switzerland. In Dev Biol, 05 Aug 2015
UNASSIGNED: To contribute to devise successful beta-cell differentiation strategies for the cure of Type1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developing pancreas.
REST and stress resistance in ageing and Alzheimer's disease.
Boston, United States. In Nature, Apr 2014
Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuron-restrictive silencer factor, NRSF) is a universal feature of normal ageing in human cortical and hippocampal neurons.
HOTAIR: a cancer-related long non-coding RNA.
In Neoplasma, 2013
Recent studies revealed HOX transcript antisense RNA, a lncRNA with regulatory functions of transcription, could bind PRC2 and LSD1/CoREST/REST complexes and direct to the specific gene sites, resulted in H3K27 methylation and H3K4 demethylation and ultimately gene silencing.