REST and stress resistance in ageing and Alzheimer's disease.
Boston, United States. In Nature, 27 Apr 2014
Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuron-restrictive silencer factor, NRSF) is a universal feature of normal ageing in human cortical and hippocampal neurons.
REST: an oncogene or a tumor suppressor?
Milano, Italy. In Trends Cell Biol, Jun 2013
The Repressor Element-1 (RE-1) Silencing Transcription (REST) factor, which is highly expressed in stem cells and non-neural cells, with low expression in neurons and other neural cells, orchestrates neural differentiation and preserves the unique neural phenotype.
Epigenetics and epilepsy.
Madison, United States. In Epilepsia, 2012
One transcription factor in particular, repressor element 1-silencing transcription factor (REST), has received a lot of attention due to the possibility that it may control fundamental transcription patterns that drive circuit excitability, seizures, and epilepsy.