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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

RER1 Rer1p

rer1, Rer1p
The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009] (from NCBI)
Papers using rer1 antibodies
Rer1p competes with APH-1 for binding to nicastrin and regulates γ-secretase complex assembly in the early secretory pathway
Supplier
Annaert Wim et al., In The Journal of Cell Biology, 2004
... Polyclonal anti-murine Rer1p was generated in New Zealand white rabbits using the C-terminal sequence CKRRYKGKEDVGKTFAS coupled to KLH (Pierce Chemical Co.) as the antigen (PickCell Laboratories).
Papers on rer1
Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.
GeneRIF
Haass et al., München, Germany. In Embo Rep, 2007
Downregulation of Rer1 leads to increased surface localization of Pen2, whereas overexpression of Rer1 stabilizes unassembled Pen2. Rer1 is the first identified interaction partner of mammalian transmembrane-based retention/retrieval signals.
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