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ATPase, H+ transporting, lysosomal accessory protein 2

renin receptor, M89
This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Renin, Angiotensin II, V1a, AT1, ATPase
Papers on renin receptor
(Pro)renin receptor contributes to regulation of renal epithelial sodium channel.
New
Siragy et al., Charlottesville, United States. In J Hypertens, Feb 2016
BACKGROUND: Recent studies reported increased (Pro)renin receptor (PRR) expression during low-salt intake.
(Pro)renin Receptor Blockade Ameliorates Cardiac Injury and Remodeling and Improves Function After Myocardial Infarction.
New
Richards et al., Christchurch, New Zealand. In J Card Fail, Jan 2016
BACKGROUND: The (pro)renin receptor [(P)RR] is implicated in the pathogenesis of cardiovascular disease.
Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia.
New
Seki et al., Saitama, Japan. In Placenta, Jan 2016
INTRODUCTION: The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling.
Activation of ENaC in Collecting Duct Cells by Prorenin and Its Receptor PRR: Involvement of Nox4-Derived Hydrogen Peroxide.
New
Yang et al., United States. In Am J Physiol Renal Physiol, Jan 2016
UNASSIGNED: The collecting duct (CD) has been recognized as an important source of prorenin/renin and it also expresses (pro)renin receptor (PRR).
Impairing effects of angiotensin-converting enzyme inhibitor Captopril on bone of normal mice.
New
Zhang et al., Nantong, China. In Eur J Pharmacol, Jan 2016
The expression of renin receptor and bradykinin B2 receptor (B2R) was significantly up-regulated in tibia of mice upon to the Captopril treatment, which decreased the ratio of OPG/RANKL and the expression of osteoblastic factor RUNX2.
Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism.
New
Danser et al., Bronkhorstspruit, South Africa. In Circ Res, Dec 2015
RATIONALE: The (pro)renin receptor [(P)RR] interacts with (pro)renin at concentrations that are >1000 times higher than observed under (patho)physiological conditions.
High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by Ceacam1 null deletion.
New
Siragy et al., Charlottesville, United States. In Am J Physiol Endocrinol Metab, Dec 2015
At baseline under regular feeding conditions, Cc1(-/-) mice exhibited higher blood pressure, urine albumin-to-creatinine ratio (UACR), and renal expression of angiotensinogen, renin/prorenin, angiotensin-converting enzyme, (pro)renin receptor, angiotensin subtype AT1 receptor, angiotensin II, and elevated PI3K phosphorylation, as detected by p85α (Tyr(508)) immunostaining, inflammatory response, and the expression of collagen I and collagen III.
[Atp6ap2/ (Pro) renin Receptor is Required for Laminar Formation during Retinal Development in Mice].
Review
New
Kanda, In Nihon Ganka Gakkai Zasshi, Nov 2015
(Pro) renin receptor [(P) RR], a key molecule for tissue renin-angiotensin system, was originally identified as Atp6ap2, an accessory subunit for vacuolar H(+)-ATPase that is a multi-subunit proton pump involved in fundamental cellular physiology.
[Pathogenic mechanism of primary hypertension].
New
Ichihara, In Nihon Rinsho, Nov 2015
Because the (pro)renin receptor is known to regulate the tissue renin-angiotensin system, brain (pro) renin receptor may be a novel therapeutic target for primary hypertension.
The Role of the (Pro)renin Receptor in Hypertensive Disease.
Review
New
Danser, Rotterdam, Netherlands. In Am J Hypertens, Oct 2015
The (pro)renin receptor ((P)RR), discovered in 2002, appeared a promising candidate, although its nanomolar affinity for renin/prorenin is many orders of magnitude above their levels in blood.
Roles of collecting duct renin and (pro)renin receptor in hypertension: mini review.
Review
New
Prieto et al., Valparaíso, Chile. In Ther Adv Cardiovasc Dis, Aug 2015
The recently named new member of the renin-angiotensin system (RAS), the (pro)renin receptor [(P)RR], is able to bind renin and the inactive prorenin, thus enhancing renin activity and fully activating prorenin.
Crosstalk between (Pro)renin receptor and COX-2 in the renal medulla during angiotensin II-induced hypertension.
Review
New
Yang, Guangzhou, China. In Curr Opin Pharmacol, Apr 2015
(Pro)renin receptor (PRR), a potential regulator of intrarenal RAS, is expressed in the intercalated cells of the collecting duct (CD) and induced by AngII, in parallel with increased renin in the principal cells of the CD.
Role of non-classical renin-angiotensin system axis in renal fibrosis.
Review
Liu et al., Nanjing, China. In Front Physiol, 2014
The new members have added new dimensions to RAS, including the ACE2/Ang(1-7)/Mas receptor axis, the prorenin/(pro)renin receptor(PRR)/intracelluar pathway axis, and the Angiotensin A (Ang A), alamandine-Mas-related G protein coupled receptor D(MrgD) axis.
Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin-angiotensin system.
Yang et al., Guangzhou, China. In Bmc Med, 2014
BACKGROUND: (Pro)renin receptor (PRR) is a new component of the renin-angiotensin system and regulates renin activity in vitro.
Brain-targeted (pro)renin receptor knockdown attenuates angiotensin II-dependent hypertension.
GeneRIF
Feng et al., New Orleans, United States. In Hypertension, 2012
Data indicate that (pro)renin receptor knockdown in the brain attenuates angiotensin II-dependent hypertension and is associated with a decrease in sympathetic tone and an improvement of the baroreflex sensitivity.
(Pro)renin receptor: another member of the system controlled by angiotensin II?
GeneRIF
Boim et al., São Paulo, Brazil. In J Renin Angiotensin Aldosterone Syst, 2012
(P)RR gene activity may be controlled by intracellular AngII.
Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway.
GeneRIF
Siragy et al., Charlottesville, United States. In Hypertension, 2012
Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway.
Renin- and prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor: does (pro)renin-(pro)renin receptor interaction actually occur?
GeneRIF
Danser et al., Rotterdam, Netherlands. In Hypertension, 2011
Angiotensin generation depending on prorenin-(P)RR interaction may occur in transgenic rodents overexpressing prorenin several 100-fold.
Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression.
GeneRIF
Harris et al., Nashville, United States. In J Am Soc Nephrol, 2011
increased expression of podocyte COX-2 predisposes to diabetic glomerular injury and the (pro)renin receptor may be one mediator for this increased susceptibility to injury
Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation.
Review
Impact
Siragy et al., Charlottesville, United States. In Endocr Rev, 2003
Here, we discuss recent advances in our understanding of the components and actions of the RAS, including local tissue RASs, a renin receptor, ANG-converting enzyme-2, ANG (1-7), the function of the ANG type 2 receptor, and ANG receptor heterodimerization.
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