High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by Ceacam1 null deletion.
Charlottesville, United States. In Am J Physiol Endocrinol Metab, Dec 2015
At baseline under regular feeding conditions, Cc1(-/-) mice exhibited higher blood pressure, urine albumin-to-creatinine ratio (UACR), and renal expression of angiotensinogen, renin/prorenin, angiotensin-converting enzyme, (pro)renin receptor, angiotensin subtype AT1 receptor, angiotensin II, and elevated PI3K phosphorylation, as detected by p85α (Tyr(508)) immunostaining, inflammatory response, and the expression of collagen I and collagen III.
[Pathogenic mechanism of primary hypertension].
In Nihon Rinsho, Nov 2015
Because the (pro)renin receptor is known to regulate the tissue renin-angiotensin system, brain (pro) renin receptor may be a novel therapeutic target for primary hypertension.
The Role of the (Pro)renin Receptor in Hypertensive Disease.
Rotterdam, Netherlands. In Am J Hypertens, Oct 2015
The (pro)renin receptor ((P)RR), discovered in 2002, appeared a promising candidate, although its nanomolar affinity for renin/prorenin is many orders of magnitude above their levels in blood.
Role of non-classical renin-angiotensin system axis in renal fibrosis.
Nanjing, China. In Front Physiol, 2014
The new members have added new dimensions to RAS, including the ACE2/Ang(1-7)/Mas receptor axis, the prorenin/(pro)renin receptor(PRR)/intracelluar pathway axis, and the Angiotensin A (Ang A), alamandine-Mas-related G protein coupled receptor D(MrgD) axis.