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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Renalase, FAD-dependent amine oxidase

renalase, RNLS
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, Presenilin-1, V1a
Papers on renalase
Genetics of long-term treatment outcome in bipolar disorder.
New
Serretti et al., Bologna, Italy. In Prog Neuropsychopharmacol Biol Psychiatry, Mar 2016
Promising findings without previous strong evidence were TRAF3IP2-AS1, NFYC, RNLS, KCNJ2, RASGRF1, NTF3 genes.
The catalytic function of renalase: A decade of phantoms.
Review
New
Moran, Milwaukee, United States. In Biochim Biophys Acta, Jan 2016
Ten years after the initial identification of human renalase the first genuinely catalytic substrates have been identified.
Renalase Levels in Children with Solitary Functioning Kidney.
New
Wasilewska et al., Białystok, Poland. In Indian Pediatr, Jan 2016
OBJECTIVE: To measure serum and urine renalase levels in children with a single kidney, and to compare with a reference group.
Establishing a low-expression renalase gene model in cardiac tissue of Sprague-Dawley rats.
New
Jiang et al., Changsha, China. In Herz, Dec 2015
CONCLUSION: LV-RNLS-RNAi (19813-1) can be used to establish an optimal renalase low-expression model for further research on the renalase system.
Effects of salt intake and potassium supplementation on renalase expression in the kidneys of Dahl salt-sensitive rats.
New
Xiao et al., Xi'an, China. In Exp Biol Med (maywood), Dec 2015
UNASSIGNED: Renalase is currently the only known amine oxidase in the blood that can metabolize catecholamines and regulate sympathetic activity.
[The history of renalase from amine oxidase to a a-NAD(P)H-oxidase/anomerase].
Review
New
Medvedev et al., Moscow, Russia. In Biomed Khim, Nov 2015
Abstract available from the publisher.
Circulating renalase, catecholamines, and vascular adhesion protein 1 in hypertensive patients.
New
Malyszko et al., Białystok, Poland. In J Am Soc Hypertens, Nov 2015
The aim of the study was to estimate and correlate circulating levels of renalase, vascular adhesion protein-1 (VAP-1), catecholamines in patients with primary hypertension.
Phenotypes of Recessive Pediatric Cataract in a Cohort of Children with Identified Homozygous Gene Mutations (An American Ophthalmological Society Thesis).
New
Alkuraya et al., Riyadh, Saudi Arabia. In Trans Am Ophthalmol Soc, Sep 2015
The remaining 12 families each had mutations in 12 different genes (CRYAA, CRYBA1, AKR1E2, AGK, BFSP2, CYP27A1, CYP51A1, EPHA2, GCNT2, LONP1, RNLS, WDR87) with unique phenotypes noted for CYP27A1 (bilateral juvenile fleck with anterior and/or posterior capsular cataract and later cerebrotendinous xanthomatosis), EPHA2 (bilateral anterior persistent fetal vasculature), and BFSP2 (bilateral flecklike with cloudy cortex).
Post-Transcriptional Regulation of Renalase Gene by miR-29 and miR-146 MicroRNAs: Implications for Cardiometabolic Disorders.
New
Mahapatra et al., Chennai, India. In J Mol Biol, Sep 2015
Renalase, a recently identified oxidoreductase, is emerging as a novel regulator of cardiovascular and metabolic disease states.
Renalase, kidney and cardiovascular disease: are they related or just coincidentally associated?
Review
New
Dobrzycki et al., Białystok, Poland. In Adv Med Sci, Mar 2015
It has been suggested that human kidney releases a protein named renalase into the bloodstream.
Effects of Renin-Angiotensin System Inhibitors on Renal Expression of Renalase in Sprague-Dawley Rats Fed With High Salt Diet.
Mu et al., Xi'an, China. In Kidney Blood Press Res, 2014
BACKGROUND/AIMS: The aim of our study was to investigate the effect of high-salt diet on the renal expression of renalase and the potential role of the local renin-angiotensin system in this process.
Recent insights on circulating catecholamines in hypertension.
Review
Hammes et al., Rochester, United States. In Curr Hypertens Rep, 2014
In an effort to target catecholamines as a means of treating hypertension, novel therapeutic options are being explored, including the generation of pharmacophores that mimic the suppressive effects of catestatin on catecholamine release as well as the use of renalase enhancers to increase catecholamine metabolism.
Serum Renalase Levels Correlate with Disease Activity in Lupus Nephritis.
Ni et al., Shanghai, China. In Plos One, 2014
Renalase is a novel, kidney-secreted cytokine-like protein that promotes cell survival.
The association study on renalase polymorphism and hypertension: a meta-analysis.
Wang et al., Chongqing, China. In Int J Clin Exp Med, 2014
Renalase is a recently discovered protein that expressed in kidney, heart, liver, and brain that metabolizes catecholamines, regulation of blood pressure in humans and animals.
Plasma renalase in chronic kidney disease: differences and similarities between humans and rats.
Review
Pestana et al., Porto, Portugal. In Curr Hypertens Rev, 2013
Renalase was described in 2005 as a new flavoprotein expressed mainly in the kidney that functions as a flavin adenine dinucleotide (FAD)- and nicotinamide adenine dinucleotide (NADH)-dependent amine oxidase.
Hypertension and kidney disease: is renalase a new player or an innocent bystander?
Review
GeneRIF
Banach et al., Białystok, Poland. In J Hypertens, 2012
polymorphisms of the renalase gene in hemodialysed patients were associated with hypertension [review]
Renalase gene polymorphisms in patients with type 2 diabetes, hypertension and stroke.
GeneRIF
Ksiazek et al., Lublin, Poland. In Neuromolecular Med, 2011
The renalase gene polymorphism was associated with hypertension in type 2 diabetes patients. The most interesting result was a strong association of the rs10887800 polymorphism with stroke in patients with and without diabetes.
Serum renalase depends on kidney function but not on blood pressure in heart transplant recipients.
GeneRIF
Mysliwiec et al., Kraków, Poland. In Transplant Proc, 2011
Renalase, highly elevated in heart transplant recipients, is predominantly dependent on kidney function, which deteriorates with time after heart transplantation and age.
Renalase, a novel regulator of blood pressure, is predicted by kidney function in renal transplant recipients.
GeneRIF
Mysliwiec et al., Białystok, Poland. In Transplant Proc, 2011
Renalase is highly elevated in kidney transplant recipients, predominantly dependent on kidney function, which deteriorates with time after kidney transplantation and age.
FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation.
GeneRIF
Aliverti et al., Milano, Italy. In J Mol Biol, 2011
Renalase adopts the p-hydroxybenzoate hydroxylase fold topology, comprising a Rossmann-fold-based flavin adenine dinucleotide (FAD)-binding domain and a putative substrate-binding domain.
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