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Regulator of G-protein signaling 1

regulator of G protein signaling, RGS1
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RGS, RGS4, CAN, RGS2, V1a
Papers on regulator of G protein signaling
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.
Review
New
Hepler et al., Atlanta, United States. In Mol Pharmacol, Feb 2016
The regulator of G protein signaling (RGS) family of proteins serves critical roles in G protein-coupled receptor (GPCR) and heterotrimeric G protein signal transduction.
The angiotensin II receptor antagonist, losartan, enhances regulator of G protein signaling 2 mRNA expression in vascular smooth muscle cells of Wistar rats.
New
Uehara et al., Shijiazhuang, China. In Hypertens Res, Feb 2016
UNASSIGNED: Angiotensin II (Ang II) reportedly enhances regulator of G-protein signaling 2 (RGS2), thus making a negative feedback loop for Ang II signal transduction.
Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
New
Kimura et al., Chiba, Japan. In J Recept Signal Transduct Res, Feb 2016
UNASSIGNED: R4/B subfamily RGS (regulator of G protein signaling) proteins play roles in regulation of many GPCR-mediated responses.
Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase-Extracellular Signal-Regulated Protein Kinase 1/2 Signaling.
Review
New
Yuan et al., Changsha, China. In Hypertension, Jan 2016
Regulator of G-protein signaling 10 (RGS10) is an important member of the RGS family and produces biological effects in multiple organs.
Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.
New
Jones et al., Cambridge, United States. In Chem Biol, Jan 2016
In addition, the CBP bromodomain inhibitor modulated the mRNA level of the regulator of G-protein signaling 4 (RGS4) gene in neurons, suggesting a potential therapeutic opportunity for CBP inhibitors in the treatment of neurological disorders.
Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation.
New
Sedding et al., Hannover, Germany. In Arterioscler Thromb Vasc Biol, Jan 2016
OBJECTIVE: Regulator of G-protein signaling 5 (RGS5) is abundantly expressed in vascular smooth muscle cells (SMCs) and inhibits G-protein signaling by enhancing the guanosine triphosphate-hydrolyzing activity of Gα-subunits.
COLD1 confers chilling tolerance in rice.
New
Impact
Chong et al., Beijing, China. In Cell, Apr 2015
COLD1 encodes a regulator of G-protein signaling that localizes on plasma membrane and endoplasmic reticulum (ER).
Regulator of G Protein Signaling 14: A Molecular Brake on Synaptic Plasticity Linked to Learning and Memory.
Review
Hepler et al., Atlanta, United States. In Prog Mol Biol Transl Sci, 2014
In the brain, regulator of G protein signaling 14 (RGS14) is enriched in neurons in the hippocampus where the mRNA and protein are highly expressed.
Keeping the Balance Right: Regulator of G Protein Signaling 5 in Vascular Physiology and Pathology.
Review
Ganss, Perth, Australia. In Prog Mol Biol Transl Sci, 2014
There has been a recent surge in studies on modulators of GPCR activity, so-called regulator of G protein signaling (RGS) molecules, due to their potential as pharmacological targets.
RGS-Insensitive G Proteins as In Vivo Probes of RGS Function.
Review
Neubig, East Lansing, United States. In Prog Mol Biol Transl Sci, 2014
Gi/o proteins are negatively regulated by regulator of G protein signaling (RGS) proteins.
Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations.
Liu et al., Hohhot, China. In Genet Mol Res, 2014
Genetic variants of the RGS5 gene are believed to be risk factors for hypertension and cardiovascular diseases.
Endocytosis of the seven-transmembrane RGS1 protein activates G-protein-coupled signalling in Arabidopsis.
Impact
Jones et al., Chapel Hill, United States. In Nat Cell Biol, 2012
The Arabidopsis thaliana heterotrimeric Gα protein self-activates without accessory proteins, and is kept in its resting state by the negative regulator, AtRGS1 (regulator of G-protein signalling 1), which is the prototype of a seven-transmembrane receptor fused with an RGS domain.
Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.
GeneRIF
Hayday et al., London, United Kingdom. In J Immunol, 2011
Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines
Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana.
GeneRIF
Dohlman et al., Chapel Hill, United States. In J Biol Chem, 2011
Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana.
Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs.
GeneRIF
Kehrl et al., Bethesda, United States. In Genes Immun, 2010
Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organs.
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.
GeneRIF
International Multiple Sclerosis Genetics Conssortium (IMSGC), In Genes Immun, 2010
RGS1 is a novel multiple sclerosis susceptibility loci, shared with celieac disease.
Glucose attenuation of auxin-mediated bimodality in lateral root formation is partly coupled by the heterotrimeric G protein complex.
GeneRIF
Jones et al., Chapel Hill, United States. In Plos One, 2009
GPA1, AGB1, AGG and RGS1 are involved in glucose attenuation of auxin-mediated lateral root formation.
Role of layer 6 of V2 visual cortex in object-recognition memory.
Impact
Khan et al., Málaga, Spain. In Science, 2009
Using the protein regulator of G protein signaling-14 (RGS-14) as a tool, we found that the expression of this protein into layer 6 neurons of rat-brain area V2 promoted the conversion of a normal short-term ORM that normally lasts for 45 minutes into long-term memory detectable even after many months.
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Impact
Todd et al., Cambridge, United Kingdom. In N Engl J Med, 2009
RESULTS: Three celiac disease loci--RGS1 on chromosome 1q31, IL18RAP on chromosome 2q12, and TAGAP on chromosome 6q25--were associated with type 1 diabetes (P<1.00x10(-4)).
Newly identified genetic risk variants for celiac disease related to the immune response.
Impact
van Heel et al., London, United Kingdom. In Nat Genet, 2008
Six regions harbor genes controlling immune responses, including CCR3, IL12A, IL18RAP, RGS1, SH2B3 (nsSNP rs3184504) and TAGAP.
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