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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Adenosine deaminase, RNA-specific, B1

RED1, ADAR2, RNA editing enzyme
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PKI, CAN, ACID, V1a, APOBEC-1
Papers on RED1
Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA.
New
Cook et al., Edinburgh, United Kingdom. In Nucleic Acids Res, 27 Jan 2016
This complex shows surprising similarity to the tandem dsRBDs from an adenosine-to-inosine editing enzyme, ADAR2 in complex with a substrate RNA.
ADAR1, inosine and the immune sensing system: distinguishing self from non-self.
New
Walkley et al., Australia. In Wiley Interdiscip Rev Rna, 21 Jan 2016
This process is catalyzed by two of the three mammalian ADAR proteins (ADAR1 and ADAR2) both of which have essential functions for normal organismal homeostasis.
Differential A-to-I RNA editing of the serotonin-2C receptor G-protein-coupled, HTR2C, in porcine brain tissues.
New
Bendixen et al., Århus, Denmark. In Biochimie, 17 Jan 2016
The HTR2C mRNA is subject to A-to-I RNA editing mediated by adenosine deaminases acting on RNA 1 and 2 (ADAR1 and ADAR2).
Differential regulation of expression of RNA-editing enzymes, ADAR1 and ADAR2, by 5-aza-2'-deoxycytidine and trichostatin A in human neuronal SH-SY5Y cells.
New
Ito et al., Ōsaka, Japan. In Neuroreport, 16 Jan 2016
Adenosine deaminase acting on RNA (ADAR) enzymes, ADAR1 and ADAR2, mediates adenosine-to-inosine RNA editing, and their mRNA expressions are altered during developmental, physiological, and pathophysiological processes in the nervous system.
ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.
New
Galter et al., Bethesda, United States. In Rna Biol, 15 Jan 2016
Adar2 KO mice die of seizures shortly after birth, but if the Gria2 Q/R editing site is mutated to mimic the edited version then the animals are viable.
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.
New
Esteller et al., Barcelona, Spain. In Oncogene, 07 Jan 2016
UNASSIGNED: The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small.
Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish.
New
Appelbaum et al., Ramat Gan, Israel. In Plos Genet, 31 Dec 2015
The expression levels of the adar genes and Adar2 protein increased in fmr1-/- zebrafish.
A Phenotypic Screen for Functional Mutants of Human Adenosine Deaminase Acting on RNA 1.
New
Beal et al., Davis, United States. In Acs Chem Biol, 20 Dec 2015
ADAR1 and ADAR2 are two members of the family that have been shown to be catalytically active.
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.
New
Impact
Stetson et al., Seattle, United States. In Immunity, 17 Dec 2015
Mutations in ADAR, which encodes the ADAR1 RNA-editing enzyme, cause Aicardi-Goutières syndrome (AGS), a severe autoimmune disease associated with an aberrant type I interferon response.
Acquisition of conditioned fear is followed by region-specific changes in RNA editing of glutamate receptors.
Gaisler-Salomon et al., New York City, United States. In Stress, 2014
Additionally, we observed experience-dependent changes in mRNA expression of the RNA editing enzymes ADAR2 and ADAR1 in amygdala and hippocampus, and a learning-dependent increase in the alternatively spliced inactive form of ADAR2 in the amygdala.
ADAR1 Facilitates HIV-1 Replication in Primary CD4+ T Cells.
Kuijpers et al., Amsterdam, Netherlands. In Plos One, 2014
Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA editing enzyme that displays antiviral activity against several RNA viruses.
Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons.
GeneRIF
Kwak et al., Tokyo, Japan. In Neurobiol Dis, 2012
These results indicated that ADAR2 downregulation is a profound pathological change relevant to death of motor neurons in ALS.
Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects.
GeneRIF
O'Connell et al., Edinburgh, United Kingdom. In Embo J, 2011
ADAR2 protein levels and catalytic activity are coordinately regulated in a positive manner by Pin1 and negatively by WWP2 and this may have downstream effects on the function of glutamate receptor 2.
An essential role of RNA editing enzyme ADAR1 in mouse skin.
GeneRIF
Wang et al., In J Dermatol Sci, 2011
Through these gene knockout animal models we demonstrated for the first time that ADAR1 is an essential molecule for skin integrity.
Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects.
GeneRIF
O'Connell et al., Edinburgh, United Kingdom. In Nucleic Acids Res, 2011
The strong functional similarity of human ADAR2 and Drosophila Adar suggests rather that these are true orthologs.
Host response to polyomavirus infection is modulated by RNA adenosine deaminase ADAR1 but not by ADAR2.
GeneRIF
Samuel et al., Santa Barbara, United States. In J Virol, 2011
These results provide evidence that ADAR1, and not ADAR2, is the deaminase responsible for protection against virus-induced cytopathic effects, and that ADAR de fi ciency does not adversely affect PyV growth.
The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove.
Impact
Allain et al., Zürich, Switzerland. In Cell, 2010
Here, we report the solution structure of the ADAR2 double-stranded RNA-binding motifs (dsRBMs) bound to a stem-loop pre-mRNA encoding the R/G editing site of GluR-2.
A new function for the RNA-editing enzyme ADAR1.
Impact
Nishikura et al., Philadelphia, United States. In Nat Immunol, 2009
This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.
Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G.
Impact
Matsuo et al., Minneapolis, United States. In Nature, 2008
The human APOBEC3G (apolipoprotein B messenger-RNA-editing enzyme, catalytic polypeptide-like 3G) protein is a single-strand DNA deaminase that inhibits the replication of human immunodeficiency virus-1 (HIV-1), other retroviruses and retrotransposons.
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.
Impact
Chiba et al., Kyoto, Japan. In Nat Med, 2007
Here we show that infection of gastric epithelial cells with 'cag' pathogenicity island (cagPAI)-positive H. pylori induced aberrant expression of activation-induced cytidine deaminase (AID), a member of the cytidine-deaminase family that acts as a DNA- and RNA-editing enzyme, via the IkappaB kinase-dependent nuclear factor-kappaB activation pathway.
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