Astrocytic 5-HT(2B) receptor as in vitro and in vivo target of SSRIs.
Shenyang, China. In Recent Pat Cns Drug Discov, 2012
Chronic treatment with fluoxetine upregulates gene expression of cPLA₂, ADAR2, GluK2 and 5-HT(2B) receptors, and RNA editing of the later two in cultured astrocytes and in astrocytes obtained by fluorescence-activated cell sorting of cells from fluoxetinetreated mice.
ADAR proteins: structure and catalytic mechanism.
Davis, United States. In Curr Top Microbiol Immunol, 2011
While a crystal structure of the catalytic domain of human ADAR2 has been solved, we still lack structural data for an ADAR catalytic domain bound to RNA, and we lack any structural data for other ADARs.
A new function for the RNA-editing enzyme ADAR1.
Philadelphia, United States. In Nat Immunol, 2009
This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.