gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RecQ protein-like 5

The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Sponsored links
Top mentioned proteins: Blm, WRN, CAN, POLYMERASE, Rad51
Papers on RecQ5
Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.
Madhusudan et al., Nottingham, United Kingdom. In Carcinogenesis, Jan 2016
RECQL5 is a member of the RecQ family of DNA helicases and has key roles in homologous recombination, base excision repair, replication and transcription.
RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability.
Mullally et al., Cambridge, United Kingdom. In Cell Rep, Jan 2016
In this study, we address this paradox by identifying the DNA helicase RECQL5 as a suppressor of genomic instability in MPNs.
RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins.
Bohr et al., Baltimore, United States. In Dna Repair (amst), Jan 2016
RECQL5 possesses relatively strong annealing activity on long or small duplexed substrates compared to the other RecQs.
Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.
Bohr et al., Baltimore, United States. In Mol Cell Biol, Jan 2016
Furthermore, we define the effects that PARP1, PARylated PARP1, and PAR have on RECQL5 and WRN, using both in vitro and in vivo assays.
Decreased RECQL5 correlated with disease progression of osteosarcoma.
Ma et al., Xi'an, China. In Biochem Biophys Res Commun, Dec 2015
Human RecQ helicase family, consisting of RECQL, RECQL4, RECQL5, BLM and WRN, has critical roles in genetic stability and tumorigenesis.
Chk1 phosphorylated at serine(345) is a predictor of early local recurrence and radio-resistance in breast cancer.
Madhusudan et al., Nottingham, United Kingdom. In Mol Oncol, Nov 2015
In 1755 early stage breast cancers, DDR signalling [ATM, ATR, total Ckh1, Chk1 phosphorylated at serine(345) (pChk1), Chk2, p53], base excision repair [PARP1, POLβ, XRCC1, FEN1, SMUG1], non-homologous end joining (Ku70/Ku80, DNA-PKcs) and homologous recombination [RAD51, BRCA1, γH2AX, BLM, WRN, RECQL5, PTEN] protein expression was correlated to time to early local recurrence.
RecQ helicases and PARP1 team up in maintaining genome integrity.
Mangerich et al., Konstanz, Germany. In Ageing Res Rev, Sep 2015
RecQL helicases (i.e., RECQL1, WRN, BLM, RECQL4, RECQL5) as well as poly(ADP-ribose) polymerases (PARPs, in particular PARP1) represent two central quality control systems to preserve genome integrity in mammalian cells.
Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population.
Lu et al., Xinxiang, China. In Genet Mol Res, 2014
We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls.
RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability.
Liu et al., Duarte, United States. In Nat Commun, 2014
RECQ5 helicase promotes TOP1 SUMOylation by facilitating the interaction between PIAS1, SRSF1 and TOP1.
RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress.
Svejstrup et al., London, United Kingdom. In Cell, 2014
RECQL5 is the sole member of the RECQ family of helicases associated with RNA polymerase II (RNAPII).
Exploring the pathophysiology behind the more common genetic and acquired lipodystrophies.
Nolis, Canada. In J Hum Genet, 2014
In the acquired forms, genes such as LMNA, PPARG, CIDEC (cell-death-inducing DNA fragmentation factor a-like effector c) and PLIN1 are heavily involved in familial partial lipodystrophy (FPLD) type 2 (also known as the Dunnigan-Variety) and WRN along with RECQL5 in Werner Syndrome (WS).
Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability.
Bohr et al., Baltimore, United States. In Crit Rev Biochem Mol Biol, 2013
The biological role of human RECQL5 is only partially understood and RECQL5 has not yet been associated with any human disease.
RecQ Helicases: Conserved Guardians of Genomic Integrity.
Hickson et al., Copenhagen, Denmark. In Adv Exp Med Biol, 2012
In humans, five RecQ family members have been identified: BLM, WRN, RECQ4, RECQ1 and RECQ5.
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.
Wang et al., Baltimore, United States. In J Biol Chem, 2012
Data indicate taht BRC repeat is a common RAD51 recombinase interaction module that can either promote homologous recombination (HR), as in the case of BRCA2, or to suppress HR, as in RECQL5 helicase.
Recruitment and retention dynamics of RECQL5 at DNA double strand break sites.
Bohr et al., Baltimore, United States. In Dna Repair (amst), 2012
the recruitment of RECQL5 to laser-induced DSB sites is independent of functional activities of its interacting partners, MRE11 and RNA polymerase II.
Anaphase DNA bridges induced by lack of RecQ5 in Drosophila syncytial embryos.
Kawasaki et al., Hirakata, Japan. In Febs Lett, 2011
lack of RecQ5 leads to spontaneous double-stranded DNA breaks
The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability.
Liu et al., New Haven, United States. In Mol Cell Biol, 2011
study provides novel insights into a mechanism by which RECQ5 regulates the transcription machinery via its dynamic interaction with RNAPII, thereby preventing genome instability
Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase
Maloney et al., Bethesda, United States. In Unknown Journal, 2011
The first-in-class probe molecule described herein (ML216) displays low micromolar potency and selectivity over related helicases, such as RECQ1, RECQ5, and E. coli UvrD helicases.
[Role of RecQ5 in syncytial blastoderm of the Drosophila embryo].
Sakurai, Hirakata, Japan. In Yakugaku Zasshi, 2010
Lack of RecQ5 causes spontaneous double-strand DNA breaks. RecQ5 may thus function in the resolution of anaphase DNA bridges during mitosis in syncytial embryo.(review)
Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome.
Furuichi et al., Kamakura, Japan. In Nat Genet, 1999
We recently cloned two new human helicase genes, RECQL4 at 8q24.3 and RECQL5 at 17q25, which encode members of the RecQ helicase family.
share on facebooktweetadd +1mail to friends