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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger, DHHC-type containing 2

REC, MCM8
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, Insulin
Papers using REC antibodies
Rearrangement enhancing element upstream of the mouse immunoglobulin kappa chain J cluster
Supplier
Hockett Richard D. et al., In The Journal of Experimental Medicine, 1995
... Internal human δREC probe was obtained by PCR amplification of cloned plasmid DNA with primers internal to those used for detecting rearrangements of transgenic human δREC ...
Papers on REC
Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: Evidence for an involvement of the neonatal Fc receptor.
New
Lang et al., Ulm, Germany. In Exp Eye Res, Feb 2016
Internalization of considerable amounts of bevacizumab by retinal endothelial (REC) and pigment epithelial cells has been observed which may affect their important functions.
In vivo characterization of the activation and interaction of the VanR/VanS two-component regulatory system controlling glycopeptide antibiotic resistance in two related Streptomyces species.
New
Hong et al., Cambridge, United Kingdom. In Antimicrob Agents Chemother, Jan 2016
A series of amino acid sequence modifications changing residues in the N-terminal receiver (REC) domain of VanRst to the corresponding residues present in VanRsc failed to create a protein capable of being activated by VanSsc and suggests that interaction of the response regulator with its cognate sensor kinase may require a more extended region than the REC domain.
NEREC, an effective brain mapping protocol for combined language and long-term memory functions.
New
Baciu et al., Grenoble, France. In Epilepsy Behav, Dec 2015
Concretely, NEREC is composed of two runs: (a) an intermixed language-memory task (confrontation naming associated with encoding in nonverbal items, NE) to map language (i.e., word retrieval and lexico-semantic processes) combined with simultaneous long-term verbal memory encoding (NE items named but also explicitly memorized) and (b) a memory retrieval task of items encoded during NE (word recognition, REC) intermixed with new items.
Genetics of primary ovarian insufficiency: new developments and opportunities.
Review
New
Chen et al., Jinan, China. In Hum Reprod Update, Nov 2015
Whole-exome sequencing in non-syndromic POI kindreds has only recently begun, revealing mutations in the Stromal antigen 3 (STAG3), Synaptonemal complex central element 1 (SYCE1), minichromosome maintenance complex component 8 and 9 (MCM8, MCM9) and ATP-dependent DNA helicase homolog (HFM1) genes.
A Scalable Genome-Editing-Based Approach for Mapping Multiprotein Complexes in Human Cells.
New
Doyon et al., Québec, Canada. In Cell Rep, Nov 2015
We uncovered subunits and interactions among well-characterized complexes and report the isolation of MCM8/9, highlighting the efficiency and robustness of the approach.
[Morphogenesis of Human Fetal Thymus during Weeks 22-27 of Development].
New
Nazarov et al., In Ontogenez, Jul 2015
Cell differentiation in the subcapsular and inner cortical zones of the thymus lobes was manifested as changes in parameters of expression of T-lymphocyte antigens CD1, CD2, and CD3 and ultrastructural features of reticuloepithelial cells (REC) type I and II forming a microenvironment for lymphocytes.
Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA.
Chen et al., Taipei, Taiwan. In Nat Commun, 2014
Phosphorylation of OmpR/PhoB response regulator induces the formation of a symmetric dimer in the N-terminal receiver domain (REC), promoting two C-terminal DNA-binding domains (DBDs) to recognize promoter DNA to elicit adaptive responses.
Reprogramming human endothelial cells to haematopoietic cells requires vascular induction.
Impact
Rafii et al., New York City, United States. In Nature, 2014
These endothelial cells that have been reprogrammed into human MPPs (rEC-hMPPs) acquire colony-forming-cell potential and durably engraft into immune-deficient mice after primary and secondary transplantation, producing long-term rEC-hMPP-derived myeloid (granulocytic/monocytic, erythroid, megakaryocytic) and lymphoid (natural killer and B cell) progenies.
The bioartificial kidney.
Review
Humes et al., Ann Arbor, United States. In Transl Res, 2014
Results also indicate REC therapy influences systemic leukocyte activation and the balance of inflammatory cytokines, suggesting that this REC therapy may improve morbidity and mortality by altering the proinflammatory state of patients.
Evolution of an MCM complex in flies that promotes meiotic crossovers by blocking BLM helicase.
Impact
Sekelsky et al., Chapel Hill, United States. In Science, 2013
We found that REC, an ortholog of MCM8 that evolved under strong positive selection in flies, interacts with MEI-217 and MEI-218, which arose from a previously undescribed metazoan-specific MCM protein.
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.
GeneRIF
Franceschini et al., Seattle, United States. In Hum Mol Genet, 2012
Single nucleotide polymorphism in MCM8 is associated with menopause and the length of reproductive lifespan.
DHHC2 is a protein S-acyltransferase for Lck.
GeneRIF
Magee et al., London, United Kingdom. In Mol Membr Biol, 2011
DHHC2 localizes primarily to the endoplasmic reticulum and Golgi apparatus suggesting that it is involved in S-acylation of newly-synthesized or recycling Lck involved in T cell signalling.
The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain.
GeneRIF
Chamberlain et al., Edinburgh, United Kingdom. In Mol Biol Cell, 2011
The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain
Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
GeneRIF
Blumer et al., Saint Louis, United States. In J Biol Chem, 2011
Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
Impact
Chasman et al., Boston, United States. In Nat Genet, 2009
For age at natural menopause, we identified 13 associated SNPs (P = 1 × 10(-7)-1 × 10(-21)) clustered at 20p12.3 (in the gene MCM8), 19q13.42
Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling.
GeneRIF
Zacharias et al., United States. In Mol Biol Cell, 2009
DHHC2-mediated palmitoylation of CKAP4 has a role in opposing cancer-related cellular behaviors.
Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression.
Impact
Lupu et al., Evanston, United States. In J Clin Oncol, 2006
METHODS: Using MCF-7 cells (Her-2 +/-) engineered to overexpress heregulin (MCF-7/HRG), a ligand for the Her-2/3/4 network, we investigated whether HRG-induced transactivation of Her-2 affected breast cancer cell sensitivity to chemotherapy and whether trastuzumab trigger receptor-enhanced chemosensitivity (REC) when combined with chemotherapy without Her-2 overexpression.
MCM proteins and DNA replication.
Review
Méchali et al., Montpellier, France. In Curr Opin Cell Biol, 2006
Recently this family expanded by the identification of two additional members that appear to be present only in multicellular organisms, MCM8 and MCM9.
MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation.
Impact
Méchali et al., Montpellier, France. In Cell, 2005
We show that the MCM2-7-related protein MCM8 is required to efficiently replicate chromosomal DNA in Xenopus egg extracts.
[Cell biology of intraocular vascular diseases].
Review
Ishibashi, In Nihon Ganka Gakkai Zasshi, 1999
The expression of tissue factor (TF), an initiator of extrinsic blood coagulation, was upregulated by VEGF in retinal vascular endothelial cells (REC).
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