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ATPase, Na+/K+ transporting, alpha 3 polypeptide

RDP, Nuclear protein, ATP1A3, DYT12
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, ATPase, AGE
Papers using RDP antibodies
STRING 8–a global view on proteins and their functional interactions in 630 organisms.
Iwasaki Akiko, In PLoS Pathogens, 2008
... Nuclear fractions were isolated by Qproteome Nuclear Protein Isolation Kit (Qiagen) and the insoluble and ...
Papers on RDP
Delivering Single-Walled Carbon Nanotubes to the Nucleus Using Engineered Nuclear Protein Domains.
Dahl et al., In Acs Appl Mater Interfaces, Feb 2016
Here we report delivery of SWCNTs to the nucleus by non-covalently attaching the tail domain of the nuclear protein lamin B1 (LB1), which we engineer from the full-length LMNB1 cDNA.
Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5' End Processing Enzymes.
Koutmos et al., Bethesda, United States. In J Mol Biol, Jan 2016
UNASSIGNED: Protein-only RNase Ps (PRORPs) are a recently discovered class of RNA processing enzymes that catalyze maturation of the 5' end of precursor tRNAs in Eukaryotes.
Association of protein structure, protein and carbohydrate subfractions with bioenergy profiles and biodegradation functions in modeled forage.
Yu et al., Tianjin, China. In Spectrochim Acta A Mol Biomol Spectrosc, Jan 2016
The parameters included: protein structure amide I group, amide II group and their ratios; protein subfractions (PA1, PA2, PB1, PB2, PC); carbohydrate fractions (CA1, CA2, CA3, CA4, CB1, CB2, CC); biodegradable and undegradable fractions of protein (RDPA2, RDPB1, RDPB2, RDP; RUPA2 RUPB1, RUPB2, RUPC, RUP); biodegradable and undegradable fractions of carbohydrate (RDCA4, RDCB1, RDCB2, RDCB3, RDCHO; RUCA4, RUCB1; RUCB2; RUCB3 RUCC, RUCHO) and bioenergy profiles (tdNDF, tdFA, tdCP, tdNFC, TDN1×, DE3×, ME3×, NEL3×; NEm, NEg).
The stress protein TP53INP1 plays a tumor suppressive role by regulating metabolic homeostasis.
Carrier et al., Marseille, France. In Biochimie, Nov 2015
In the recent years, we have provided evidence that Tumor Protein 53-Induced Nuclear Protein 1 (TP53INP1) is a key stress protein with antioxidant-associated tumor suppressive function.
[ATP1A3 gene mutations in patients with alternating hemiplegia of childhood].
Wu et al., Beijing, China. In Zhonghua Er Ke Za Zhi, Nov 2015
OBJECTIVE: To analyze the ATP1A3 mutations in patients with alternating hemiplegia of childhood (AHC) and recognize its value in diagnosing atypical cases.
Isolated and combined dystonia syndromes - an update on new genes and their phenotypes.
Bhatia et al., London, United Kingdom. In Eur J Neurol, Apr 2015
Similarly, ATP1A3 mutations cause a wide phenotypic spectrum ranging from rapid-onset dystonia-parkinsonism to alternating hemiplegia of childhood.
The expanding spectrum of neurological phenotypes in children with ATP1A3 mutations, Alternating Hemiplegia of Childhood, Rapid-onset Dystonia-Parkinsonism, CAPOS and beyond.
Swoboda et al., Salt Lake City, United States. In Pediatr Neurol, 2015
BACKGROUND: ATP1A3 mutations have now been recognized in infants and children presenting with a diverse group of neurological phenotypes, including Rapid-onset Dystonia-Parkinsonism (RDP), Alternating Hemiplegia of Childhood (AHC), and most recently, Cerebellar ataxia, Areflexia, Pes cavus, Optic atrophy, and Sensorineural hearing loss (CAPOS) syndrome.
Nuclear protein in testis midline carcinoma with unusual elevation of α-fetoprotein and synaptophysin positivity: a case report and review of the literature.
Mirshahidi et al., Loma Linda, United States. In Expert Rev Anticancer Ther, 2014
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare cancer that displays a characteristic chromosomal rearrangement of BRD4-NUT t(15;19)(q14;q13.1).
Successful Recovery of Nuclear Protein-Coding Genes from Small Insects in Museums Using Illumina Sequencing.
Maddison et al., Corvallis, United States. In Plos One, 2014
In this paper we explore high-throughput Illumina sequencing of nuclear protein-coding, ribosomal, and mitochondrial genes in small, dried insects stored in natural history collections.
Distinct neurological disorders with ATP1A3 mutations.
ATP1A3 Working Group et al., Durham, United States. In Lancet Neurol, 2014
Genetic research has shown that mutations that modify the protein-coding sequence of ATP1A3, the gene encoding the α3 subunit of Na(+)/K(+)-ATPase, cause both rapid-onset dystonia parkinsonism and alternating hemiplegia of childhood.
Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expression.
Jung et al., Los Angeles, United States. In J Virol, 2012
the transcription elongation of KSHV OriLytL-K7 lytic genes is inhibited by NELF during latency, but can also be promptly reactivated in an RTA-independent manner upon external stimuli
Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study.
Gärtner et al., Göttingen, Germany. In Lancet Neurol, 2012
Mutation analysis of the ATP1A3 gene in patients who met clinical criteria.
De novo mutations in ATP1A3 cause alternating hemiplegia of childhood.
Goldstein et al., Durham, United States. In Nat Genet, 2012
This work identifies de novo ATP1A3 mutations as the primary cause of alternating hemiplagia of childhood and offers insight into disease pathophysiology by expanding the spectrum of phenotypes associated with mutations in ATP1A3.
Agrin-signaling is necessary for the integration of newly generated neurons in the adult olfactory bulb.
Cremer et al., Marseille, France. In J Neurosci, 2012
An interaction between agrin and alpha3-Na+K+-ATPase is of functional importance in newly generated neurons in the adult olfactory bulb.
Similarities between the Epstein-Barr Virus (EBV) Nuclear Protein EBNA1 and the Pioneer Transcription Factor FoxA: Is EBNA1 a "Bookmarking" Oncoprotein that Alters the Host Cell Epigenotype?
Minarovits et al., Regensburg, Germany. In Pathogens, 2011
EBNA1, a nuclear protein expressed in all EBV-associated neoplasms is indispensable for the maintenance of the viral episomes in latently infected cells.
Immunohistochemical analyses of alpha1 and alpha3 Na+/K+-ATPase subunit expression in medulloblastomas.
Lefranc et al., Brussels, Belgium. In Anticancer Res, 2011
There was overexpression of the alpha1 or alpha3 NaK subunits in more than half of the medulloblastomas.
Mutations in THAP1 (DYT6) and generalised dystonia with prominent spasmodic dysphonia: a genetic screening study.
Klein et al., Lübeck, Germany. In Lancet Neurol, 2009
This combination of symptoms might be a characteristic feature of DYT6 dystonia and could be useful in the differential diagnosis of DYT1, DYT4, DYT12, and DYT17 dystonia.
Structural basis for nuclear import complex dissociation by RanGTP.
Stewart et al., Cambridge, United Kingdom. In Nature, 2005
Nuclear protein import is mediated mainly by the transport factor importin-beta that binds cytoplasmic cargo, most often via the importin-alpha adaptor, and then transports it through nuclear pore complexes.
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