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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAD52 motif 1

This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: DRD1, POLYMERASE, CAN, STEP, ACID
Papers on RDM1
Angiosperms Are Unique among Land Plant Lineages in the Occurrence of Key Genes in the RNA-Directed DNA Methylation (RdDM) Pathway.
Leitch et al., London, United Kingdom. In Genome Biol Evol, Sep 2015
Six proteins were restricted to angiosperms, these being NRPD4/NRPE4, RDM1, DMS3 (defective in meristem silencing 3), SHH1 (SAWADEE homeodomain homolog 1), KTF1, and SUVR2, although we failed to find the latter three proteins in Fritillaria persica, a species with a giant genome.
The SET domain proteins SUVH2 and SUVH9 are required for Pol V occupancy at RNA-directed DNA methylation loci.
He et al., Beijing, China. In Plos Genet, 2014
Our results indicated that SUVH2 and/or SUVH9 not only interact with the chromatin-remodeling complex termed DDR (DMS3, DRD1, and RDM1) but also with the newly characterized complex composed of two conserved Microrchidia (MORC) family proteins, MORC1 and MORC6.
The ability to form homodimers is essential for RDM1 to function in RNA-directed DNA methylation.
Matzke et al., Taipei, Taiwan. In Plos One, 2013
RDM1 (RNA-DIRECTED DNA METHYLATION1) is a small plant-specific protein required for RNA-directed DNA methylation (RdDM).
Enhanced bioavailability and anthelmintic efficacy of mebendazole in redispersible microparticles with low-substituted hydroxypropylcellulose.
Bolás-Fernández et al., Madrid, Spain. In Drug Des Devel Ther, 2013
RDM-1:2.5 and RDM-1:5 resulted in increased maximum plasma concentration and area(s) under the curve (AUC)0-∞ values.
Differential expression of DNA repair genes in Hispanic women with breast cancer.
Suarez et al., Ponce, Puerto Rico. In Mol Cancer Biol, 2013
Those candidate genes were CHEK2, EME1 (MMS4L), ERCC3 (XPB), FANCM, H2AFX (H2AX), HMGB1, HUS1, MBD4, NEIL3, PCNA, RAD1, RAD23B, RAD51, RAD54B, RDM1 (RAD52B), SHFM1 (DSS1), TP1, UBE2N (UBC13) and XRCC5 (Ku80).
A transcription fork model for Pol IV and Pol V-dependent RNA-directed DNA methylation.
Cocklin et al., Bloomington, United States. In Cold Spring Harb Symp Quant Biol, 2011
A multiprotein complex (DRD1, DMS3, DMS11, RDM1) known to enable Pol V transcription might facilitate duplex unwinding via ATP-dependent DNA translocase, single-stranded DNA binding, and cohesin-like strand capture activities.
The important molecular markers on chromosome 17 and their clinical impact in breast cancer.
Yu et al., Shanghai, China. In Int J Mol Sci, 2010
Several famous oncogenes (HER2, TOP2A and TAU), tumor suppressor genes (p53, BRCA1 and HIC-1) or DNA double-strand break repair gene (RDM1) are located on chromosome 17.
Scattered regulatory regions of the chicken immunoglobulin-β gene and two adjacent promoters of ubiquitously expressed genes interact with the immunoglobulin-β promoter in DT40 cells.
Ono et al., Tokyo, Japan. In Biol Pharm Bull, 2010
We found that the Ig-β promoter also interacted with two downstream promoters of ubiquitously expressed genes, rad motif 1 (RDM1) and Plekhm1, to form a transcription factory, but not with three ubiquitously expressed genes, BAF60b, p45/SUG, and RRMJ3, located upstream of the Ig-β gene.
A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis.
Jacobsen et al., Los Angeles, United States. In Curr Biol, 2010
Through affinity purification of two known RdDM components, DEFECTIVE IN RNA-DIRECTED DNA METHYLATION 1 (DRD1) and DEFECTIVE IN MERISTEM SILENCING 3 (DMS3), we found that they copurify with each other and with a novel protein, RNA-DIRECTED DNA METHYLATION 1 (RDM1), forming a complex we term DDR.
An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.
Zhu et al., Riverside, United States. In Nature, 2010
Here we report a new regulator of RNA-directed DNA methylation (RdDM) in Arabidopsis: RDM1.
Subcellular distribution of human RDM1 protein isoforms and their nucleolar accumulation in response to heat shock and proteotoxic stress.
Van Dyck et al., Lyon, France. In Nucleic Acids Res, 2006
The identification of 11 human cDNAs encoding RDM1 protein isoforms which is generated by alternative pre-mRNA splicing and differential usage of two translational start sites.
Nucleic acid-binding properties of the RRM-containing protein RDM1.
Van Dyck et al., Lyon, France. In Biochem Biophys Res Commun, 2006
RDM1 (RAD52 Motif 1) is a vertebrate protein involved in the cellular response to the anti-cancer drug cisplatin.
RDM1, a novel RNA recognition motif (RRM)-containing protein involved in the cell response to cisplatin in vertebrates.
Van Dyck et al., Lyon, France. In J Biol Chem, 2005
RDM1 recognizes DNA distortions induced by cisplatin-DNA adducts in vitro; possible role in spermatogenesis
Acute effects of desmin mutations on cytoskeletal and cellular integrity in cardiac myocytes.
Klymkowsky et al., Boulder, United States. In Cell Motil Cytoskeleton, 2003
RDM-1 and RDM-2 blocked in vitro assembly at the unit-length filament stage, while RDM-3 had more subtle effects on assembly.
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