KCC2 knockdown impairs glycinergic synapse maturation in cultured spinal cord neurons.
Heidelberg, Germany. In Histochem Cell Biol, Feb 2016
At the same time period of postnatal development, the transmembrane chloride gradient is changed due to increased expression of the potassium-chloride cotransporter (KCC2), thereby shifting the GABA- and glycine-mediated synaptic currents from mostly excitatory depolarization to inhibitory hyperpolarization.
The Long and Winding Road to Gamma-Amino-Butyric Acid as Neurotransmitter.
Montréal, Canada. In Can J Neurol Sci, Feb 2016
Starting with the early studies that established GABA as an inhibitory neurotransmitter at central synapses, we summarize the results pointing at the GABA receptor as a drug target as well as more recent evidence showing that GABAA receptor signaling plays a surprisingly active role in neuronal network synchronization, both during development and in the adult brain.
Arithmetic and local circuitry underlying dopamine prediction errors.
Cambridge, United States. In Nature, Oct 2015
Furthermore, selectively exciting and inhibiting neighbouring GABA (γ-aminobutyric acid) neurons in the ventral tegmental area reveals that these neurons are a source of subtraction: they inhibit dopamine neurons when reward is expected, causally contributing to prediction-error calculations.
The Involvement of GABAB signaling in the Antipsychotic-like Action of the Novel Orthosteric Agonist of mGlu4 Receptor, LSP4-2022.
Kraków, Poland. In Curr Neuropharmacol, Jun 2015
UNASSIGNED: Because ligands of metabotropic glutamate and GABA receptors may exert beneficial effects in schizophrenia, we have assessed the actions of the first mGlu4-selective orthosteric agonist, LSP4-2022in several tests reflecting positive, negative and cognitive symptoms of schizophrenia, and we investigated the possible involvement of GABAB receptors in LSP4-2022-induced actions.Hyperactivity induced by MK-801 or amphetamine and DOI-induced head twitches induced in mice were used as the models for positive symptoms.