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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Resistant to dieldrin

Rdl, GABA, Leo1
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, HAD, OUT
Papers using Rdl antibodies
Heterogeneity of membrane properties in sympathetic preganglionic neurons of neonatal mice: evidence of four subpopulations in the intermediolateral nucleus
Supplier
Deuchars Susan A. et al., In Frontiers in Neurology, 2009
... Drugs, a GABAB agonist baclofen and an antagonist CGP55845 (both from Tocris Cookson, Bristol, UK), were ...
Long-lasting reactive changes observed in microglia in the striatal and substantia nigral of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Supplier
Hong Jau-Shyong et al., In Environmental Health Perspectives, 2006
... H]γ-aminobutyric acid (GABA; 90 Ci/mmol) from PerkinElmer Life Sciences (Boston, MA) ...
Deblurring of 3-dimensional patterns of evoked rat cerebellar cortical activity: a study using voltage-sensitive dyes and optical sectioning
Supplier
D'Angelo Egidio et al., In Frontiers in Cellular Neuroscience, 1991
... When needed, the extracellular solution was added with the GABA-A receptor blocker, 10 μM gabazine (SR-95531, Tocris Cookson), or the NMDA ...
Papers on Rdl
Chronic alcohol exposure disrupts CB1 regulation of GABAergic transmission in the rat basolateral amygdala.
New
Roberto et al., Los Angeles, United States. In Addict Biol, Feb 2016
The endogenous cannabinoid/type 1 cannabinoid receptor (eCB/CB1 ) system curbs BLA-driven anxiety and stress responses via a retrograde negative feedback system that inhibits neurotransmitter release, and BLA CB1 activation reduces GABA release and drives anxiogenesis.
KCC2 knockdown impairs glycinergic synapse maturation in cultured spinal cord neurons.
New
Kuhse et al., Heidelberg, Germany. In Histochem Cell Biol, Feb 2016
At the same time period of postnatal development, the transmembrane chloride gradient is changed due to increased expression of the potassium-chloride cotransporter (KCC2), thereby shifting the GABA- and glycine-mediated synaptic currents from mostly excitatory depolarization to inhibitory hyperpolarization.
Neuropathological relationship between major depression and dementia: A hypothetical model and review.
Review
New
Lafer et al., Toronto, Canada. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2016
This may be due to decreased neurogenesis from lower levels of brain-derived neurotrophic factor (BDNF), excitotoxicity from increased glutamate signaling, and lower levels of gamma-aminobutyric acid (GABA) signaling.
Involvement of opioid and gaba systems in the ventrolateral periaqueductal gray on analgesia associated with tonic immobility.
New
Ramírez-San Juan et al., Mexico. In Pharmacol Biochem Behav, Feb 2016
The aim of this study was to assess the role of the opioid and the GABA systems in TI-elicited analgesia.
Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites.
Review
New
Selzer et al., Glasgow, United Kingdom. In Chemmedchem, Feb 2016
Ligand-gated chloride channels (LGCCs) modulated by γ-aminobutyric acid (GABA) and glutamate have been identified as suitable molecular targets, and several classes of potent parasiticides have been devised.
Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs.
New
Aoyama et al., Nagano, Japan. In J Food Sci Technol, Jan 2016
CoQ10, GABA/rutin, and GABA/IP6 were abundant in broccoli, buckwheat, and germinated soybean PSs, respectively.
Glia as drivers of abnormal neuronal activity.
Review
New
Sontheimer et al., Roanoke, United States. In Nat Neurosci, Jan 2016
New research now extends the role of astrocytes, suggesting that they may drive the disease process by impairing the inhibitory action of neuronal GABA receptors.
Rational search for genes in familial cortical myoclonic tremor with epilepsy, clues from recent advances.
Review
New
Luo et al., Hangzhou, China. In Seizure, Jan 2016
Clues from neuropathological, clinical, neurophysiological and neuroimaging studies indicate that the candidate causative genes should be expressed in the cerebellum, especially in Purkinje cells, and be associated with calcium signaling and GABA receptors.
Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.
New
Impact
Broccoli et al., Milano, Italy. In Cell Stem Cell, Jan 2016
iGABA-INs display progressively maturing firing patterns comparable to cortical INs, form functional synapses, and release GABA.
Identification of a Group of GABAergic Neurons in the Dorsomedial Area of the Locus Coeruleus.
New
Jiang et al., Atlanta, United States. In Plos One, Dec 2015
Although GABA is the major inhibitory neurotransmitter of LC neurons, the modulation of LC neuronal firing activity by local GABAergic interneurons remains poorly understood with respect to their precise location, intrinsic membrane properties and synaptic modulation.
Arithmetic and local circuitry underlying dopamine prediction errors.
New
Impact
Uchida et al., Cambridge, United States. In Nature, Oct 2015
Furthermore, selectively exciting and inhibiting neighbouring GABA (γ-aminobutyric acid) neurons in the ventral tegmental area reveals that these neurons are a source of subtraction: they inhibit dopamine neurons when reward is expected, causally contributing to prediction-error calculations.
FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders.
New
Impact
Vaccarino et al., New Haven, United States. In Cell, Aug 2015
Autism spectrum disorder (ASD) is a disorder of brain development.
Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders.
Review
New
Impact
Paspalas et al., New Haven, United States. In Pharmacol Rev, Jul 2015
These effects likely involve hyperpolarization-activated cyclic nucleotide-gated channel opening, activation of GABA interneurons, and reduced glutamate release.
The Involvement of GABAB signaling in the Antipsychotic-like Action of the Novel Orthosteric Agonist of mGlu4 Receptor, LSP4-2022.
Review
New
Wieronska et al., Kraków, Poland. In Curr Neuropharmacol, Jun 2015
UNASSIGNED: Because ligands of metabotropic glutamate and GABA receptors may exert beneficial effects in schizophrenia, we have assessed the actions of the first mGlu4-selective orthosteric agonist, LSP4-2022in several tests reflecting positive, negative and cognitive symptoms of schizophrenia, and we investigated the possible involvement of GABAB receptors in LSP4-2022-induced actions.Hyperactivity induced by MK-801 or amphetamine and DOI-induced head twitches induced in mice were used as the models for positive symptoms.
Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.
New
Impact
Cancedda et al., Genova, Italy. In Nat Med, Apr 2015
Our findings demonstrate that GABA is excitatory in adult DS mice and identify a new therapeutic approach for the potential rescue of cognitive disabilities in individuals with DS.
Antagonistic regulation of PAF1C and p-TEFb is required for oligodendrocyte differentiation.
GeneRIF
Huh et al., Ansan, South Korea. In J Neurosci, 2012
results indicate that antagonistic regulation of gene expression by PAF1Cand p-TEFb plays a crucial role in oligodendrocyte development in the CNS.
Leo1 subunit of the yeast paf1 complex binds RNA and contributes to complex recruitment.
GeneRIF
Buratowski et al., Boston, United States. In J Biol Chem, 2010
Leo1 subunit of the yeast paf1 complex binds RNA and contributes to complex recruitment
Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene.
GeneRIF
French et al., Rotterdam, Netherlands. In Genes Chromosomes Cancer, 2010
Screened glioblastomas and oligodendrogliomas for fusion genes by identifying aberrant 5'-3' expression of genes that lie over regions of a copy number change. A fusion gene between exon 11 of LEO1 and exon 10 of SLC12A1 was identified.
Molecular characterization of agonists that bind to an insect GABA receptor.
GeneRIF
Lummis et al., Cambridge, United Kingdom. In Biochemistry, 2010
model of the insect GABA receptor binding site and the location of agonists within it
Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila.
GeneRIF
Nässel et al., Stockholm, Sweden. In Plos One, 2009
insulin-like peptides express the metabotropic GABA(B) receptor (GBR), but not the ionotropic GABA(A) receptor subunit RDL
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