Rods Feed Cones to Keep them Alive.
Basel, Switzerland. In Cell, Jun 2015
Aït-Ali et al. describe a molecular mechanism by which RdCVF, a factor normally released by rods, controls glucose entry into cones, enhancing their survival.
Gene therapy for the eye focus on mutation-independent approaches.
Paris, France. In Curr Opin Neurol, Feb 2015
To extend gene therapy's promise to a large number of patients, evidence suggests retina-specific trophic factors, such as rod-derived cone viability factor, can be used to slow down loss of cone cells responsible for our high acuity vision.
[Neuroprotection of photoreceptor cells in rod-cone dystrophies: from cell therapy to cell signalling].
Paris, France. In C R Biol, 2005
Our group has (1) established and confirmed the existence of non cell autonomous mechanisms promoting cone cell viability; (2) shown that rod cell protection or replacement provides a mean to extend the survival of cones; (3) demonstrated that rod-cone trophic interactions are mediated by diffusible proteins; (4) identified by expression cloning a protein mediating such interactions: RdCVF (Rod-derived Cone Viability Factor).