Integration of the Rac1- and actin-binding properties of Coronin-1C.
Bristol, United Kingdom. In Small Gtpases, 2014
We recently reported 2 interactions that were unique to coronin-1C: binding of a Rac1 inhibitor, RCC2, to the unique linker region and Rac1 itself to the propeller domain in a manner that differs from that proposed for other coronins.
TD-60 links RalA GTPase function to the CPC in mitosis.
Edinburgh, United Kingdom. In Nat Commun, 2014
TD-60 (also known as RCC2) is a highly conserved protein that structurally resembles the Ran guanine exchange factor (GEF) RCC1, but has not previously been shown to have GEF activity.
Proteomic analysis of integrin adhesion complexes.
Manchester, United Kingdom. In Sci Signal, 2010
In particular, we identified regulator of chromosome condensation-2 (RCC2) as a component of fibronectin-activated signaling pathways that regulate directional cell movement.