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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulator of chromosome condensation 2

RCC2, TD-60, regulator of chromosome condensation-2
Top mentioned proteins: RCC1, CAN, XRCC1, Aurora, Rac1
Papers on RCC2
Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers.
Kennedy et al., Christchurch, New Zealand. In Pharmacogenomics J, Oct 2015
Exome-wide variant filtering highlighted four genes potentially associated with thiopurine metabolism (ENOSF1 and NFS1), transport (SLC17A4) or therapeutic action (RCC2).
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.
Lothe et al., Oslo, Norway. In Clin Cancer Res, Sep 2015
RESULTS: We identified the cell-cycle gene regulator of chromosome condensation 2 (RCC2) as a cancer biomarker.
Integration of the Rac1- and actin-binding properties of Coronin-1C.
Bass et al., Bristol, United Kingdom. In Small Gtpases, 2014
We recently reported 2 interactions that were unique to coronin-1C: binding of a Rac1 inhibitor, RCC2, to the unique linker region and Rac1 itself to the propeller domain in a manner that differs from that proposed for other coronins.
TD-60 links RalA GTPase function to the CPC in mitosis.
Earnshaw et al., Edinburgh, United Kingdom. In Nat Commun, 2014
TD-60 (also known as RCC2) is a highly conserved protein that structurally resembles the Ran guanine exchange factor (GEF) RCC1, but has not previously been shown to have GEF activity.
Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure.
Bass et al., Bristol, United Kingdom. In J Cell Sci, 2014
Here, we identify interactions between coronin-1C (Coro1C), RCC2 and Rac1 that focus active Rac1 to a single protrusion.
Effects of thermotherapy on Th1/Th2 cells in esophageal cancer patients treated with radiotherapy.
Zhou et al., Nanjing, China. In Asian Pac J Cancer Prev, 2013
Both groups received conventional radiotherapy using a cobalt-60 therapy apparatus (TD60-66Gy/30-33F).
TD-60 is required for interphase cell cycle progression.
Margolis et al., Los Angeles, United States. In Cell Cycle, 2013
We previously identified TD-60 (RCC2) as a mitotic centromere-associated protein that is necessary for proper completion of mitosis.
Melanoma risk loci as determinants of melanoma recurrence and survival.
Kirchhoff et al., New York City, United States. In J Transl Med, 2012
RESULTS: We identified significant associations for rs7538876 (RCC2) with RFS (HR=1.48,
MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2.
Moriyama et al., Ōita, Japan. In Mol Cancer, 2012
RCC2, PPIC and CDK6 were commonly downregulated in miR-29c-transfected MKN45, MKN7 and MKN74 cells, and all of the genes harbored miR-29c target sequences in the 3'-UTR of their mRNA.
Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells.
Fox et al., Charlottesville, United States. In J Proteomics, 2012
a complex containing cortactin and RCC2/TD60 complex that may play a functional role in cells undergoing mitosis.
Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage.
Marto et al., Boston, United States. In J Proteome Res, 2011
Studies indicated that DDX21, HNRNPC, and RCC2 were isolated from Ku86 multicomponent complex in response to DNA damage.
Proteomic analysis of integrin adhesion complexes.
Humphries et al., Manchester, United Kingdom. In Sci Signal, 2010
In particular, we identified regulator of chromosome condensation-2 (RCC2) as a component of fibronectin-activated signaling pathways that regulate directional cell movement.
A novel case of t(X;1)(p11.2;p34) in a renal cell carcinoma with TFE3 rearrangement and favorable outcome in a 57-year-old patient.
Pedeutour et al., Nice, France. In Cancer Genet Cytogenet, 2010
This incidence is underestimated in adults because its morphological similarities with clear-cell RCC or papillary RCC2,3, as well as immunohistochemical and cytogenetic analyses are not carried out systematically in adults.
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.
Humphries et al., Manchester, United Kingdom. In Sci Signal, 2008
Dysregulation of Rac1 and Arf6 function by RCC2 knockdown also abolished persistent migration along fibronectin fibers, indicating a functional role for RCC2 in directional cell movement.
Integrin proteomes reveal a new guide for cell motility.
Danen, Leiden, Netherlands. In Sci Signal, 2008
One of these, regulator of chromosome condensation-2 (RCC2), represents an unexpected molecular connection between integrins and the cell-migration machinery.
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2008
The 1p36 locus contains the candidate genes PADI4, PADI6, RCC2 and ARHGEF10L, and the gene nearest to the 1q42 locus is the ras-homolog RHOU.
Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation.
Stukenberg et al., Charlottesville, United States. In Science, 2008
First, Aurora-B activation in vitro requires two cofactors, telophase disc-60kD (TD-60) and microtubules.
The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.
Margolis et al., Grenoble, France. In Dev Cell, 2003
Data show that TD-60 is a member of the RCC1 family and that it binds preferentially the nucleotide-free form of the small G protein Rac1.
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