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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulator of chromosome condensation 1

RCC1, Chromosome condensation
Top mentioned proteins: RAN, CAN, ACID, importin, RanGAP1
Papers using RCC1 antibodies
A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo
Zheng Yixian et al., In The Journal of Cell Biology, 1999
... Human RCC1 was cloned into pEGFP-N3 (CLONTECH Laboratories, Inc.) and transfected ...
Papers on RCC1
Chromatin binding of RCC1 during mitosis is important for its nuclear localization in interphase.
Fukagawa et al., Mishima, Japan. In Mol Biol Cell, Feb 2016
RCC1, a guanine nucleotide exchange factor of the small GTPase Ran, plays various roles throughout the cell cycle.
Identification of Novel Fusion Genes in Testicular Germ Cell Tumors.
Skotheim et al., Oslo, Norway. In Cancer Res, Feb 2016
Two of the recurrent transcripts involved an intrachromosomal fusion between RCC1 and HENMT1 located 80 Mbp apart and an interchromosomal fusion between RCC1 and ABHD12B.
Compound heterozygous mutations in NEK8 in siblings with end-stage renal disease with hepatic and cardiac anomalies.
Spinner et al., Atlanta, United States. In Am J Med Genet A, Jan 2016
The mutations included a c.2069_2070insC variant (p.Ter693LeufsTer86), and a c.1043C>T variant (p.Thr348Met) in the highly conserved RCC1 (Regulation of Chromosome Condensation 1) domain.
Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects.
Kerem et al., Jerusalem, Israel. In Cell Stem Cell, Jan 2016
Here, we show that aneuploid hPSCs undergo DNA replication stress, resulting in defective chromosome condensation and segregation.
Stable Chromosome Condensation Revealed by Chromosome Conformation Capture.
Kornberg et al., Stanford, United States. In Cell, Dec 2015
Chemical cross-linking and DNA sequencing have revealed regions of intra-chromosomal interaction, referred to as topologically associating domains (TADs), interspersed with regions of little or no interaction, in interphase nuclei.
Lysine-acetylation as a fundamental regulator of Ran function: Implications for signaling of proteins of the Ras-superfamily.
Lammers et al., Köln, Germany. In Small Gtpases, Nov 2015
We recently reported that lysine-acetylation regulates nearly all aspects of Ran-function such as RCC1 catalyzed nucleotide exchange, intrinsic nucleotide hydrolysis, its interaction with NTF2 and the formation of import- and export-complexes.
Nucleosome functions in spindle assembly and nuclear envelope formation.
Funabiki et al., New York City, United States. In Bioessays, Oct 2015
Both processes require the generation of RanGTP by RCC1 recruited to nucleosomes but nucleosomes also acquire cell cycle stage specific regulators, Aurora B in mitosis and ELYS, the initiator of nuclear pore complex assembly, at mitotic exit.
Caffeine-Induced Premature Chromosome Condensation Results in the Apoptosis-Like Programmed Cell Death in Root Meristems of Vicia faba.
Balcerczyk et al., Łódź, Poland. In Plos One, 2014
We have demonstrated that the activation of apoptosis-like programmed cell death (AL-PCD) was a secondary result of caffeine (CF) induced premature chromosome condensation (PCC) in hydroxyurea-synchronized Vicia faba root meristem cells.
Structural maintenance of chromosome complex in bacteria.
Graumann et al., San Diego, United States. In J Mol Microbiol Biotechnol, 2013
Chromosome condensation is essential in all cells and ranges from 1,000- to more than 10,000-fold between bacterial and eukaryotic cells.
The role of the nucleosome acidic patch in modulating higher order chromatin structure.
Hansen et al., Fort Collins, United States. In J R Soc Interface, 2013
The co-structures of five different proteins with the nucleosome (LANA, IL-33, RCC1, Sir3 and HMGN2) recently have been examined by experimental and computational studies.
Spatiotemporal control of microtubule nucleation and assembly using magnetic nanoparticles.
Gueroui et al., Paris, France. In Nat Nanotechnol, 2013
Here, we show that magnetic nanoparticles conjugated with key regulatory proteins can artificially control, in time and space, the Ran/RCC1 signalling pathway that regulates the cell cytoskeleton.
Deciphering how the chromatin factor RCC1 recognizes the nucleosome: the importance of individuals in the scientific discovery process.
Tan, United States. In Biochem Soc Trans, 2012
My laboratory recently determined the structural basis for how the RCC1 (regulator of chromosome condensation 1) chromatin factor binds to the nucleosome, including the first atomic crystal structure of a chromatin protein complexed with the nucleosome core particle.
Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts.
Heald et al., Berkeley, United States. In Plos Biol, 2011
RCC1 can induce bipolar spindle formation. Remarkably, RCC1 beads oscillate within spindles from pole to pole, a behavior that could be converted to a more typical, stable association by the addition of a kinesin together with RCC1.
Genotype-phenotype associations and human eye color.
Rabago-Smith et al., Flint, United States. In J Hum Genet, 2011
Although there are about 16 different genes responsible for eye color, it is mostly attributed to two adjacent genes on chromosome 15, hect domain and RCC1-like domain-containing protein 2 (HERC2) and ocular albinism (that is, oculocutaneous albinism II (OCA2)).
Structure of RCC1 chromatin factor bound to the nucleosome core particle.
Tan et al., United States. In Nature, 2010
This concentration gradient is created by the chromatin-bound RCC1 (regulator of chromosome condensation) protein, which recruits Ran to nucleosomes and activates Ran's nucleotide exchange activity.
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
Macara et al., Charlottesville, United States. In Nature, 2010
discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT).
RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complex.
Tan et al., United States. In J Mol Biol, 2010
The authors find that RCC1 uses a conformationally flexible loop region we have termed the switchback loop in addition to its N-terminal tail to bind to the nucleosome.
Apoptotic histone modification inhibits nuclear transport by regulating RCC1.
Li et al., Singapore, Singapore. In Nat Cell Biol, 2009
Therefore, we propose that RCC1 reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus.
Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1.
Macara et al., Charlottesville, United States. In J Cell Biol, 2008
The N-terminal tail of RCC1 is essential for association with DNA but inhibits histone binding.
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