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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Regulator of chromosome condensation 1

RCC1, Chromosome condensation
Papers using RCC1 antibodies
A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo
Supplier
Zheng Yixian et al., In The Journal of Cell Biology, 1999
... Human RCC1 was cloned into pEGFP-N3 (CLONTECH Laboratories, Inc.) and transfected ...
Papers on RCC1
Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts.
GeneRIF
Heald et al., Berkeley, United States. In Plos Biol, 2011
RCC1 can induce bipolar spindle formation. Remarkably, RCC1 beads oscillate within spindles from pole to pole, a behavior that could be converted to a more typical, stable association by the addition of a kinesin together with RCC1.
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
Impact
GeneRIF
Macara et al., Charlottesville, United States. In Nature, 2010
discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT).
RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complex.
GeneRIF
Tan et al., United States. In J Mol Biol, 2010
The authors find that RCC1 uses a conformationally flexible loop region we have termed the switchback loop in addition to its N-terminal tail to bind to the nucleosome.
Apoptotic histone modification inhibits nuclear transport by regulating RCC1.
Impact
GeneRIF
Li et al., Singapore, Singapore. In Nat Cell Biol, 2009
Therefore, we propose that RCC1 reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus.
Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1.
GeneRIF
Macara et al., Charlottesville, United States. In J Cell Biol, 2008
The N-terminal tail of RCC1 is essential for association with DNA but inhibits histone binding.
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