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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Estrogen receptor binding site associated, antigen, 9

RCAS1, EBAG9
This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, V1a, AGE, CD25
Papers on RCAS1
Diagnostic value of soluble receptor-binding cancer antigen expressed on SiSo cells and carcinoembryonic antigen in differentiating malignant from benign pleural effusion.
New
Zhu et al., Hefei, China. In Tumour Biol, Nov 2015
The aim of this study was to evaluate the diagnostic value of combined detection of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) and carcinoembryonic antigen (CEA) in patients with MPE and benign pleural effusion (BPE).
Analysis of the intensity of immune cell infiltration and immunoreactivity of RCAS1 in diffuse large B-cell lymphoma of the palatine tonsil and its microenvironment.
New
Dutsch-Wicherek et al., Bydgoszcz, Poland. In Cell Tissue Res, Sep 2015
RCAS1 (receptor cancer-binding antigen expressed on SiSo cells) has been demonstrated to be associated with poor prognosis, the development of lymph node metastases and participation in tumor microenvironment remodeling.
Expression of RCAS1 correlates with urothelial bladder cancer malignancy.
Slominski et al., Bydgoszcz, Poland. In Int J Mol Sci, 2014
RCAS1 is a protein that participates in regulation of the tumor microenvironment and its immune responses, all in order to evade the immune system.
Clinical significance and prognostic value of serum RCAS1 in patients with non-small cell lung cancer.
Zhang et al., Nanjing, China. In Int J Biol Markers, 2014
UNASSIGNED: Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that induces cell-cycle arrest and apoptosis in cells.
Serum receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a diagnostic and prognostic marker for non-small cell lung cancer.
Zhang et al., In Tumori, 2014
BACKGROUND: Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that induces cell-cycle arrest and apoptosis in cells bearing the RCAS1 receptor.
The clinical and pathological significance of RCAS1 expression as a prognostic biomarker in non-small cell lung cancer.
Theocharis et al., Athens, Greece. In In Vivo, 2014
Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a protein that can be expressed in cancer cells and is involved in tumor cell escape from immune system surveillance.
Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma.
Nakamura et al., Fukuoka, Japan. In J Transl Med, 2013
BACKGROUND: Receptor-binding cancer antigen expressed on SiSo cell (RCAS1) is derived from uterine adenocarcinoma and can induce apoptosis in lymphocytes, allowing tumor cells to escape from immune surveillance.
EBAG9 modulates host immune defense against tumor formation and metastasis by regulating cytotoxic activity of T lymphocytes.
Inoue et al., Saitama, Japan. In Oncogenesis, 2013
Estrogen receptor-binding fragment-associated antigen 9 (EBAG9) is a primary estrogen-responsive gene that we previously identified in MCF-7 breast cancer cells using the CpG genomic binding-site cloning technique.
A disintegrin and metalloproteinase 9 is involved in ectodomain shedding of receptor-binding cancer antigen expressed on SiSo cells.
Kato et al., Fukuoka, Japan. In Biomed Res Int, 2013
In several human malignancies, the expression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is associated with aggressive characteristics and poor overall survival.
Creation of a suppressive microenvironment by macrophages and cancer-associated fibroblasts.
Review
Kazmierczak et al., Bydgoszcz, Poland. In Front Biosci, 2012
In the present review we discuss the role of various cells like tumor-associated macrophages and cancer-associated fibroblasts, expressing RCAS1, B7-H4 molecules, and MT in creating the suppressive profile of the cancer microenvironment and in the cancer microenvironment remodeling that enables both local tumor spread and the creation of metastases.
The immunohistochemical analysis of antigens such as RCAS1 and B7H4 in the cervical cancer nest and within the fibroblasts and macrophages infiltrating the cancer microenvironment.
GeneRIF
Wicherek et al., Kraków, Poland. In Am J Reprod Immunol, 2012
The intensity of the suppressive profile of the cervical cancer microenvironment indicated by the presence of both RCAS1 and B7H4 on the front of the tumor and in the macrophages and fibroblasts infiltrating the cancer stroma
Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions.
GeneRIF
Theocharis et al., Athens, Greece. In Med Sci Monit, 2012
RCAS1 protein may participate in thyroid neoplastic transformation and could be considered as a useful biomarker to improve diagnostic scrutiny.
Novel therapeutic strategies to target RCAS1, which induces apoptosis via ectodomain shedding.
Review
Sonoda, Fukuoka, Japan. In Histol Histopathol, 2011
The expression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is associated with aggressive characteristics and poor overall survival for 15 different human malignancies.
The analysis of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) immunoreactivity within the microenvironment of the ovarian cancer lesion relative to the applied therapeutic strategy.
GeneRIF
Wicherek et al., Bydgoszcz, Poland. In Cell Tissue Res, 2011
The immunoreactivity of RCAS1 on the cells present in the ovarian cancer microenvironment, was analysed.
RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical study.
GeneRIF
Sastre-Garau et al., Paris, France. In Med Sci Monit, 2011
Data suggest that RCAS1 may be involved in the early stages of tumor progression in mobile tongue squamous cell carcinoma.
Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region.
GeneRIF
Ariga et al., Sapporo, Japan. In Int J Oncol, 2011
EBAG9 overexpression can be causative in enhancing the malignant properties of tumor cells.
RCAS1, MT, and vimentin as potential markers of tumor microenvironment remodeling.
Review
Dutsch-Wicherek, Kraków, Poland. In Am J Reprod Immunol, 2010
For instance, RCAS1 is a protein responsible for tumor escape from host immunologic surveillance that additionally seems to be involved in the remodeling of the microenvironment.
Receptor-binding cancer antigen expressed on SiSo cells (RCAS1): a novel biomarker in the diagnosis and prognosis of human neoplasia.
Review
GeneRIF
Theocharis et al., Athens, Greece. In Histol Histopathol, 2009
tissue RCAS1 expression...considered as an informative biomarker in several types of human malignancy
The biological role of the unique molecule RCAS1: a bioactive marker that induces connective tissue remodeling and lymphocyte apoptosis.
Review
GeneRIF
Wake et al., Fukuoka, Japan. In Front Biosci, 2007
RCAS1 is a bioactive marker that induces connective tissue remodeling and lymphocyte apoptosis [review]
Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1.
Impact
Watanabe et al., Fukuoka, Japan. In Nat Med, 1999
Here we describe RCAS1 (receptor-binding cancer antigen expressed on SiSo cells), a membrane molecule expressed on human cancer cells.
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