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Retinol binding protein 4, plasma

RBP, RBP4
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, CAN, HAD, AGE, fibrillin-1
Papers using RBP antibodies
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Supplier
Kong Ling-Dong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... The enzyme-linked immunosorbent assay (ELISA) kits for L-carnitine (KA0860, Abnova), retinol-binding protein (RBP, E90929Ra, Uscn), β2-microglobulin (β2-MG, E0260r, EIAab) and uromodulin (UMOD, E96918Ra, ...
Papers on RBP
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
New
Girkontaitė et al., Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
RESULTS: Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls.
Orthogonal matrix factorization enables integrative analysis of multiple RNA binding proteins.
New
Curk et al., Ljubljana, Slovenia. In Bioinformatics, Feb 2016
To model protein-RNA interactions by considering all available sources of information, it is necessary to integrate the rapidly growing RBP experimental data with the latest genome annotation, gene function, RNA sequence and structure.
High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.
New
Penalva et al., San Antonio, United States. In Rna Biol, Feb 2016
However, due to the complex nature of RNA-binding proteins, these studies are incomplete without assays that characterize the impact of RBP binding on mRNA target expression.
RNA-binding proteins, neural development and the addictions.
Review
New
Yazdani et al., Boston, United States. In Genes Brain Behav, Jan 2016
Key challenges include identifying the biological functions of the dynamic RBP targetomes from specific cell types throughout subcellular space (e.g. the nuclear spliceome vs. the synaptic translatome) and time and manipulating RBP programs through post-transcriptional modifications to prevent or reverse aberrant neurodevelopment and plasticity underlying the addictions.
A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes.
New
Impact
Taylor et al., Basel, Switzerland. In Cancer Cell, Jan 2016
Genetic inactivation of RBP-Jκ, a key Notch mediator, or Notch1 and Notch2 receptors accelerates PDGF-driven glioma growth in mice.
Development of an Assay for the Identification of Receptor Binding Proteins from Bacteriophages.
New
Szymanski et al., Edmonton, Canada. In Viruses, Dec 2015
When phage P22 was screened using this assay, Gp9 was the only RBP discovered, confirming previous predictions that this is the sole RBP encoded by this phage.
Retinol Binding Protein 4 in Relation to Diet, Inflammation, Immunity, and Cardiovascular Diseases.
Review
New
Mahmoudi et al., Tehrān, Iran. In Adv Nutr, Nov 2015
Retinol binding protein 4 (RBP4), previously called retinol binding protein (RBP), is considered a specific carrier of retinol in the blood.
Emerging Roles of Disordered Sequences in RNA-Binding Proteins.
Review
New
Richard et al., Montréal, Canada. In Trends Biochem Sci, Nov 2015
RBP-RNA interactions form ribonucleoprotein (RNP) complexes and emerging evidence indicates that RNPs form higher structures or lattices, promoting territories of phase transitions.
The role of TARBP2 in the development and progression of cancers.
Review
New
Li et al., Beijing, China. In Tumour Biol, Nov 2015
UNASSIGNED: TARBP2 is a RNA-binding protein (RBP) involved in miRNA processing and maturation.
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization.
New
Impact
Taylor et al., Memphis, United States. In Cell, Oct 2015
Here, we demonstrate that the disease-related RBP hnRNPA1 undergoes liquid-liquid phase separation (LLPS) into protein-rich droplets mediated by a low complexity sequence domain (LCD).
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
New
Impact
Dotto et al., Lausanne, Switzerland. In Nat Cell Biol, Sep 2015
Loss or downmodulation of the Notch effector CSL (also known as RBP-Jκ) in dermal fibroblasts is sufficient for CAF activation and ensuing keratinocyte-derived tumours.
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD.
New
Impact
Wong et al., Baltimore, United States. In Science, Sep 2015
However, a limited understanding of this RNA-binding protein (RBP) impedes the clarification of pathogenic mechanisms underlying TDP-43 proteinopathy.
Biochemical Basis for Dominant Inheritance, Variable Penetrance, and Maternal Effects in RBP4 Congenital Eye Disease.
New
Impact
Glaser et al., Ann Arbor, United States. In Cell, May 2015
We identified missense mutations in RBP4, encoding serum retinol binding protein, in three families with eye malformations of differing severity, including bilateral anophthalmia.
Sitagliptin downregulates retinol-binding protein 4 and upregulates glucose transporter type 4 expression in a type 2 diabetes mellitus rat model.
Fang et al., Hefei, China. In Int J Clin Exp Med, 2014
The present study was designed to investigate the effects of sitagliptin on metabolic parameters as well as the expression levels of retinol-binding protein 4 (RBP4) and glucose transporter type 4 (GLUT4) in a rat model of type 2 diabetes mellitus.
A Comparison of the Effects of Aerobic and Intense Exercise on the Type 2 Diabetes Mellitus Risk Marker Adipokines, Adiponectin and Retinol Binding Protein-4.
Review
Cobbold et al., Cardiff, United Kingdom. In Int J Chronic Dis, 2013
Plasma levels of two adipocyte-originating cytokines, adiponectin and retinol binding protein 4 (RBP-4), alter following exercise.
Association among retinol-binding protein 4, small dense LDL cholesterol and oxidized LDL levels in dyslipidemia subjects.
GeneRIF
Wang et al., Nanjing, China. In Clin Biochem, 2012
RBP4 may play an important role in lipid metabolism of atherosclerosis, particularly in formation of sdLDL.
Are plasma levels of visfatin and retinol-binding protein 4 (RBP4) associated with body mass, metabolic and hormonal disturbances in women with polycystic ovary syndrome?
GeneRIF
Skałba et al., Katowice, Poland. In Eur J Obstet Gynecol Reprod Biol, 2012
RBP4 level reflects visceral body fat content in non-polycystic ovary syndrome women.
Metabolic manifestations of polycystic ovary syndrome in nonobese adolescents: retinol-binding protein 4 and ectopic fat deposition.
GeneRIF
Oberfield et al., New York City, United States. In Fertil Steril, 2012
Suggest that RBP4 may be involved in the dyslipidemia associated with polycystic ovary syndrome in nonobese adolescents and that there may be an independent relationship between RBP4 and triglycerides but not between RBP4 and insulin resistance.
Alterations in systemic concentrations of progesterone during the early luteal phase affect RBP4 expression in the bovine uterus.
GeneRIF
Crowe et al., Galway, Ireland. In Reprod Fertil Dev, 2011
progesterone modulates uterine RBP4 mRNA and protein abundance in a time- and concentration-dependent manner.
Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children.
GeneRIF
Rosenbaum et al., New York City, United States. In J Pediatr Endocrinol Metab, 2010
In early- to mid-adolescents, circulating concentrations of RBP4 are correlated with multiple risk factors for adiposity-related co-morbidities.
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