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RNA binding motif protein, Y-linked, family 1, member A1

RBMY, RBM1, YRRM1
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: DAZ, MEN, CAN, POLYMERASE, HAD
Papers on RBMY
RBMY, a novel inhibitor of glycogen synthase kinase 3β, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma.
New
Chang et al., Taipei, Taiwan. In Hepatology, Nov 2015
The discovery of oncogenic activation of RBMY (RNA-binding motif on Y chromosome), which is absent in normal hepatocytes but present in male HCC tissues, sheds light on this issue.
Combination with third-generation bisphosphonate (YM529) and interferon-alpha can inhibit the progression of established bone renal cell carcinoma.
New
Furihata et al., Kōchi, Japan. In Cancer Sci, Aug 2015
For the in vivo study, male athymic BALB/cA Jc1-nu nude mice bearing human RCC cell line RBM1-IT4 cells were treated with YM529 and/or IFN-α.
Copy number variation in the human Y chromosome in the UK population.
New
Xue et al., Sanger, United States. In Hum Genet, Jul 2015
These included a large duplication encompassing the AMELY and TBL1Y genes that probably has no phenotypic effect, partial deletions of the TSPY cluster and AZFc region that may influence spermatogenesis, and other variants with unknown functional implications, including abundant variation in the number of RBMY genes and/or pseudogenes, and a novel complex duplication of two segments overlapping the AZFa region and including the 3' end of the UTY gene.
Straightforward access to spisulosine and 4,5-dehydrospisulosine stereoisomers: probes for profiling ceramide synthase activities in intact cells.
Delgado et al., Barcelona, Spain. In J Org Chem, 2013
Among the sphingoid bases described in this work, spisulosine (ES285), RBM1-77, and RBM1-73 were the most suitable ones because of their highest acylation rates.
Expression analysis of RNA-binding motif gene on Y chromosome (RBMY) protein isoforms in testis tissue and a testicular germ cell cancer-derived cell line (NT2).
Sabbaghian et al., Tehrān, Iran. In Iran Biomed J, 2013
BACKGROUND: RNA-binding motif gene on Y chromosome (RBMY), a germ cell-specific nuclear protein, is known as a key factor in spermatogenesis and disorders associated with this protein have been recognized to be related to male infertility.
Cellular ontogeny of RBMY during human spermatogenesis and its role in sperm motility.
Modi et al., Mumbai, India. In J Biosci, 2013
The Y-chromosome-encoded gene RBMY (RNA-binding motif on Y) is a male germline RNA-binding protein and is postulated to be a RNA-splicing regulator.
Expression of Tra2 β in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis.
Elliott et al., Newcastle upon Tyne, United Kingdom. In Int J Cell Biol, 2012
Tra2 β protein is also known to interact directly with the RBMY protein which is implicated in liver cancer.
A rare Y chromosome constitutional rearrangement: a partial AZFb deletion and duplication within chromosome Yp in an infertile man with severe oligoasthenoteratozoospermia.
Huang et al., Nanjing, China. In Int J Androl, 2011
The patient, who showed a 46,XY karyotype, had an approximate 2.4 Mb inherited duplication region in Yp11.2 and a de novo partial AZFb deletion, which spanned 5.25 Mb including eight protein coding genes and four non-coding transcripts, but did not remove the RBMY gene family.
Identifying mRNAs bound by human RBMY protein in the testis.
GeneRIF
Ma et al., Chengdu, China. In J Reprod Dev, 2011
investigation of role of RBMY in spermatogenesis: isolation and identification of RBMY target mRNAs in testis; RBMY binds to only transcript variant 2 of Nek10; RBMY may take part in alternative splicing of Nek10
Male germ cell-specific RNA binding protein RBMY: a new oncogene explaining male predominance in liver cancer.
Chang et al., Taipei, Taiwan. In Plos One, 2010
The RNA binding motif gene on the Y chromosome (RBMY), encoding a male germ cell-specific RNA splicing regulator during spermatogenesis, is aberrantly activated in human male liver cancers.
[46, XX testicular disorder of sex development: report of 2 cases and review of the literature].
Review
Zhou et al., Nanjing, China. In Zhonghua Nan Ke Xue, 2010
METHODS: We obtained the history of 2 patients with 46, XX testicular disorder of sex development, examined the cavitas pelvis by type-B ultrasonography, analyzed the karyotype of the chromosome, and detected the genes SRY, YRRM1, DYS240 and DAZ by PCR amplification.
Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}.
GeneRIF
Stévenin et al., Illkirch-Graffenstaden, France. In J Cell Sci, 2010
regulates germline-specific splicing events
The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.
GeneRIF
Elliott et al., Newcastle upon Tyne, United Kingdom. In Plos Genet, 2009
germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein.
Identification of target messenger RNA substrates for mouse RBMY.
GeneRIF
Ma et al., Chengdu, China. In Mol Hum Reprod, 2008
mRBMY protein may have high affinity to oligo(A) rich sequences; mRBMY protein can bind to the testis and sperm-specific spa17 mRNA
Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis.
GeneRIF
Castro et al., Santiago, Chile. In Mol Hum Reprod, 2007
Patients with complete Sertoli cell-only syndrome (SCOS) did not exhibit RBMY1 gene expression.
The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis.
Review
Elliott, Newcastle upon Tyne, United Kingdom. In Int J Androl, 2004
Investigations into the RBM gene family are uncovering networks of protein interactions which regulate RNA processing, and which might operate downstream of signal transduction pathways.
Y chromosome microdeletions and alterations of spermatogenesis.
Review
Impact
Ferlin et al., Padova, Italy. In Endocr Rev, 2001
Deletions in these regions remove one or more of the candidate genes (DAZ, RBMY, USP9Y, and DBY) and cause severe testiculopathy leading to male infertility.
RBMY genes and AZFb deletions.
Review
Elliott, Edinburgh, United Kingdom. In J Endocrinol Invest, 2000
These include a number of RBMY genes, which are clustered in the AZFb deletion interval.
A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome.
Impact
Graves et al., Australia. In Nat Genet, 1997
Three genes, RBM1, DAZ and TSPY, map to a small region of the long arm of the human Y chromosome which is deleted in azoospermic men.
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