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RNA binding motif, single stranded interacting protein

RBMS3, RNA-binding protein RBMS3
This gene encodes an RNA-binding protein that belongs to the c-myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] (from NCBI)
Papers on RBMS3
Rbms3, an RNA-binding protein, mediates the expression of Ptf1a by binding to its 3'UTR during mouse pancreas development.
Chiang et al., T'ai-chung-shih, Taiwan. In Dna Cell Biol, 2012
binding of Rbms3 to the 3'UTR of Ptf1a regulates the production of the Ptf1a protein
Genomewide pharmacogenetics of bisphosphonate-induced osteonecrosis of the jaw: the role of RBMS3.
Zavras et al., New York City, United States. In Oncologist, 2011
genetic susceptibility plays a role in the pathophysiology of Bisphosphonate-related osteonecrosis of the jaw (BRONJ), with RBMS3 having a significant effect in the risk.
Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma.
Guan et al., Guangzhou, China. In Cancer Res, 2011
a tumor suppression function for the human RBMS3 gene in esophageal squamous cell carcinoma, acting through c-Myc downregulation, with genetic loss of this gene contributing to poor outcomes in disease
RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1.
Stefanovic et al., Tallahassee, United States. In J Mol Biol, 2007
These results suggest that RBMS3, by binding Prx1 mRNA in a sequence-specific manner, controls Prx1 expression and indirectly collagen synthesis.
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