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Ras association

The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MSP, V1a, MST2, Tec, SESN3
Papers on RASSF4
RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion.
Wang et al., Shenyang, China. In Tumour Biol, Dec 2015
UNASSIGNED: RASSF4 has been implicated as a tumor suppressor in several human cancers.
Decreased expression and frequent promoter hypermethylation of RASSF2 and RASSF6 correlate with malignant progression and poor prognosis of gastric cardia adenocarcinoma.
Yang et al., Shijiazhuang, China. In Mol Carcinog, Nov 2015
The present study investigated the role and methylation status of RASSF2, RASSF3, RASSF4, and RASSF6 in the pathogenesis and prognosis of GCA.
RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT.
Liu et al., Wuhan, China. In Biochem Biophys Res Commun, Apr 2015
As a member of the RAS association domain family (RASSFs), RASSF4 plays important roles in cell death, tumor development and signal transduction.
Promoter methylation status of Ras-association domain family members in pheochromocytoma.
Dammann et al., Gießen, Germany. In Front Endocrinol (lausanne), 2014
In this study, we observed inactivating DNA modifications for the RASSF members RASSF2, RASSF5A, RASSF9, and RASSF10, but not for the members RASSF3, RASSF4, RASSF5C, RASSF6, RASSF7, and RASSF8.
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
Linardic et al., In J Clin Invest, 2014
We have now found that this bypass occurs in part through PAX3-FOXO1-mediated upregulation of RASSF4, a Ras-association domain family (RASSF) member.
Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.
Sato et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2013
Expression of the tumor suppressor gene Ras association domain family member 4 (RASSF4) was found to be suppressed in SPRR1B-overexpressed cells.
Transdifferentiation of mesenchymal stem cells-derived adipogenic-differentiated cells into osteogenic- or chondrogenic-differentiated cells proceeds via dedifferentiation and have a correlation with cell cycle arresting and driving genes.
Ringe et al., Berlin, Germany. In Differentiation, 2013
However, the upregulation (CCND1, CHEK, HGF, HMGA2, SMAD3) and downregulation (CCPG1, RASSF4, RGS2) of these genes have an association with cell cycle progression and maybe motivate dedifferentiation of adipogenic-differentiated cells.
Combined RASSF1A and RASSF2A Promoter Methylation Analysis as Diagnostic Biomarker for Bladder Cancer.
Lautenschlaeger et al., Columbus, United States. In Mol Biol Int, 2011
In this paper, DNA promoter methylation of five C-terminal Ras-association family members (RASSF1A, RASSF2A, RASSF4, RASSF5, and RASSF6) was studied in 64 formalin-fixed paraffin-embedded (FFPE) bladder cancer and normal adjacent tissues using methylation-specific high-resolution melting (MS-HRM) analysis.
The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma.
Carén et al., Göteborg, Sweden. In Mol Cancer, 2011
RESULTS: In the current study, we found that several of the RASSF family genes (RASSF2, RASSF4, RASSF5, RASSF6, RASSF7, and RASSF10) to various degrees were methylated in neuroblastoma cell lines and primary tumors.
N-terminal RASSF family: RASSF7-RASSF10.
Latif et al., Birmingham, United Kingdom. In Epigenetics, 2011
RASSF1A (Ras Association Domain Family 1 isoform A) tumor suppressor gene is one of the most frequently epigenetically inactivated genes in a wide range of adult and children's cancers and could be a useful molecular marker for cancer diagnosis and prognosis.
Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences.
Dammann et al., Gießen, Germany. In Mol Cancer, 2009
BACKGROUND: The Ras association domain family (RASSF) encodes for distinct tumor suppressors and several members are frequently silenced in human cancer.
Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinoma.
Dammann et al., Gießen, Germany. In Oncol Rep, 2009
Here we analyzed the promoter methylation of 15 genes (RASSF1A, p16, MGMT, DAPK, RARbeta, MLH1, CDH1, GSTP1, RASSF2, RASSF4, RASSF5, MST1, MST2, LATS1, LATS2) in 54 HNSCC and in matching 23 normal tissues.
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
Relling et al., Memphis, United States. In Blood, 2009
Single nucleotide polymorphism in RASSF4 gene is associated with acute lymphoblastic leukemia.
Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
Williams et al., Cardiff, United Kingdom. In Am J Med Genet B Neuropsychiatr Genet, 2007
We studied 23 positional/functional candidate genes from our linkage region on chromosome 10 (APBB1IP, ALOX5, AD037, SLC18A3, DKK1, ZWINT, ANK3, UBE2D1, CDC2, SIRT1, JDP1, NET7, SUPV3L1, NEN3, SAR1, SGPL1, SEC24C, CAMK2G, PP3CB, SNCG, CH25H, PLCE1, ANXV111) in the MRC genetic resource for LOAD.
RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family.
Clark et al., Rockville, United States. In Cancer Res, 2005
We now identify a fifth member of this group, RASSF4 (AD037).
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