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RAS guanyl releasing protein 4

Rasgrp4
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: NF1, p38, LRP15, Neph3, ERK
Papers on Rasgrp4
Activity-dependent genes in mouse olfactory sensory neurons.
McClintock et al., Lexington, United States. In Chem Senses, 2014
Both unilateral naris occlusion of mice for 6 days and genetic silencing of OSNs decreased S100A5, Lrrc3b, Kirrel2, Slc17a6, Rasgrp4, Pcp4l1, Plcxd3, and Kcnn2 while increasing Kirrel3.
GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
GeneRIF
Stephens et al., Cambridge, United Kingdom. In Embo J, 2012
GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
Impact
Shannon et al., San Francisco, United States. In Nature, 2009
We cloned clone-specific retroviral integrations to identify candidate resistance genes including Rasgrp1, Rasgrp4 and Mapk14, which encodes p38alpha.
Possible involvement of RasGRP4 in leukemogenesis.
GeneRIF
Kitamura et al., Tokyo, Japan. In Int J Hematol, 2009
RasGRP4 cooperates with AML1 mutations in T cell leukemogenesis as a class I mutation
The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.
GeneRIF
Krilis et al., Australia. In J Biol Chem, 2008
RasGRP4 translocates to varied intracellular compartments via its DAG/PMA-binding domain to regulate signaling pathways that control gene and protein expression in MCs, including the cell's ability to respond to IL-13.
RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines.
GeneRIF
Stevens et al., Boston, United States. In J Biol Chem, 2003
RasGRP4 regulates the expression of prostaglandin D2 in mast cells
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function.
GeneRIF
Stevens et al., Boston, United States. In J Biol Chem, 2002
identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function
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