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RAS protein activator like 1

RASAL, RASAL1, RAS protein activator like-1
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: GAP, CAN, CAPRI, Sar1, ERK1
Papers on RASAL
EBP1 suppresses growth, migration, and invasion of thyroid cancer cells through upregulating RASAL expression.
Zhang et al., Linyi, China. In Tumour Biol, Nov 2015
Knockdown RASAL by transduction of RASAL1 shRNA lentiviral particles markedly reduced RASAL levels with restoration of EBP1, and RASAL1 knockdown abrogated the effects of forced EBP1 expression on cell growth, migration, and invasiveness of thyroid tumor cells.
Mycophenolic acid reverses TGF beta-induced cell motility, collagen matrix contraction and cell morphology in vitro.
Oellerich et al., Göttingen, Germany. In Cell Biochem Funct, Oct 2015
The following assays were applied: cell proliferation, viability, collagen matrix contraction, scratch wound closure, spindle index, FACS with anti-CD29 and anti-CD326, promoter demethylation of RAS protein activator like 1 (RASAL1), as well as gene expression of RASAL1, integrin 1ß (ITGB1) (CD29) and epithelial cell adhesion molecule (EpCam) (CD326).
Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy.
Hinton et al., Los Angeles, United States. In Invest Ophthalmol Vis Sci, Aug 2015
Expression of RASAL1 mRNA and its promoter region methylation were evaluated by real-time PCR and methylation-specific PCR.
Spijker et al., Amsterdam, Netherlands. In J Biol Chem, Jul 2015
DBA mice showed a prominent decrease in the Ras-GAP calcium-sensing protein RASAL1.
Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.
Zeisberg et al., Göttingen, Germany. In Cardiovasc Res, Apr 2015
METHODS AND RESULTS: In human coronary endothelial cells, TGFβ1 causes aberrant methylation of RASAL1 promoter, increased Ras-GTP activity, and EndMT.
Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease.
Zeisberg et al., Göttingen, Germany. In Ebiomedicine, 2015
Here, we report that transcriptional silencing of the Ras-GTP suppressor RASAL1 contributes causally to progression of kidney fibrosis and we identified that circulating methylated RASAL1 promoter DNA fragments in peripheral blood correspond with levels of intrarenal levels of RASAL1 promoter methylation and degree of fibrosis in kidney biopsies, enabling non-invasive longitudinal analysis of intrarenal CpG island methylation.
Chromosome 12 long arm rearrangement covering MDM2 and RASAL1 is associated with aggressive craniofacial juvenile ossifying fibroma and extracranial psammomatoid fibro-osseous lesions.
de Pinieux et al., Tours, France. In Mod Pathol, 2015
To investigate possible polysomy of chromosome 12, we studied RASAL1 amplification, a gene telomeric to MDM2 on the long arm of chromosome 12.
Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.
Castellone et al., Napoli, Italy. In Plos One, 2014
Interestingly, the mRNA expression analyses indicated that SOD3 regulated the expression of guanine nucleotide-exchange factors (RHO GEF16, RAL GEF RGL1), GTPase-activating proteins (ARFGAP ADAP2, RAS GAP RASAL1, RGS4), and a Rho guanine nucleotide-disassociation inhibitor (RHO GDI 2) in a dose dependent manner, thus controlling signaling through the small G protein GTPases.
Effect of DNA demethylation in experimental encapsulating peritoneal sclerosis.
Park et al., Taegu, South Korea. In Ther Apher Dial, 2014
Methylation-specific polymerase chain reaction (PCR) for Ras GTPase activating-like protein 1 (RASAL1) was performed with measurement of RASAL1 protein expression.
RASAL1 attenuates gastric carcinogenesis in nude mice by blocking RAS/ERK signaling.
Wang et al., Nanjing, China. In Asian Pac J Cancer Prev, 2014
Recent studies have suggested that the RAS protein activator like-1 (RASAL1) functions as a tumor suppressor in vitro and may play an important role in the development of gastric cancer.
Germline alterations in RASAL1 in Cowden syndrome patients presenting with follicular thyroid cancer and in individuals with apparently sporadic epithelial thyroid cancer.
Eng et al., Cleveland, United States. In J Clin Endocrinol Metab, 2014
CONTEXT: RASAL1 has recently been identified as an important tumor suppressor for sporadic thyroid tumorigenesis, particularly for follicular thyroid cancer (FTC) and anaplastic thyroid cancer.
RASAL1 influences the proliferation and invasion of gastric cancer cells by regulating the RAS/ERK signaling pathway.
Zhang et al., Nanjing, China. In Hum Cell, 2014
The aim of this study was to investigate the biological characteristics of the RASAL1 gene in a well-differentiated gastric cancer cell line MKN-28 and a poorly differentiated gastric cancer cell line BGC-823 cells, using RNA interference and gene transfection technology, respectively.
Reduced expression of RAS protein activator like-1 in gastric cancer.
Omata et al., Tokyo, Japan. In Int J Cancer, 2011
Reduced expression of RAS protein activator like-1 is associated with gastric cancer.
Methylation determines fibroblast activation and fibrogenesis in the kidney.
Zeisberg et al., Boston, United States. In Nat Med, 2010
We demonstrate here that hypermethylation of RASAL1, encoding an inhibitor of the Ras oncoprotein, is associated with the perpetuation of fibroblast activation and fibrogenesis in the kidney.
Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression.
Omata et al., Tokyo, Japan. In Gastroenterology, 2009
Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression.
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
Tao et al., Hong Kong, Hong Kong. In Proc Natl Acad Sci U S A, 2007
RASAL constitutes a tumor suppressor gene and therefore further emphasized the importance of Ca(2+) in the regulation of Ras signaling and has established that deregulation of this pathway is an important step in Ras-mediated tumorigenesis
CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.
Lockyer et al., Cambridge, United Kingdom. In J Cell Biol, 2005
RASAL preservs of Ca2+ frequency information
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity.
Agami et al., Amsterdam, Netherlands. In Cell, 2005
Finally, we identified RASAL1, a RAS-GTPase-activating protein, as a transcription target through which PITX1 affects RAS function.
RASA1: variable phenotype with capillary and arteriovenous malformations.
Vikkula et al., Brussels, Belgium. In Curr Opin Genet Dev, 2005
Thus, RASA1 defects probably cause abnormal angiogenic remodeling of the primary capillary plexus that cannot be compensated for by other RasGAPs: RASA2, RASAL and NF1.
Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.
Stork et al., Portland, United States. In J Biol Chem, 2002
Galpha and Gbeta gamma require distinct Src-dependent pathways for its activation
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