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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Retinoic acid receptor, beta

RARbeta, BAG-1, glutathione S-transferase fusion protein, HET
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, RAR, CAN, HAD, POLYMERASE
Papers on RARbeta
Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo.
New
Takeuchi et al., Ōsaka, Japan. In Neurogastroenterol Motil, Feb 2016
METHODS: To determine the role of NCX in gastrointestinal tissues, we examined electric field stimulation (EFS)-induced relaxations in the circular muscles of the gastric fundus in NCX1 and NCX2 heterozygote knockout mice (HET).
β-Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-κB Signaling Pathway.
New
Guan et al., Zhengzhou, China. In J Biochem Mol Toxicol, Feb 2016
Cav-1 protein was expressed only in ESCC cells, not in Het-1A cells.
NAP-1, Nucleosome assembly protein 1, a histone chaperone involved in Drosophila telomeres.
New
Casacuberta et al., Barcelona, Spain. In Insect Biochem Mol Biol, Jan 2016
The targeted transposition of the telomere transposons HeT-A, TART and TAHRE perform this function in Drosophila, while the telomerase mechanism elongates the telomeres in most eukaryotes.
Behavioural Effects of High Fat Diet in a Mutant Mouse Model for the Schizophrenia Risk Gene Neuregulin 1.
New
Karl et al., Copenhagen, Denmark. In Genes Brain Behav, Jan 2016
transmembrane domain Nrg1 mutant mice: Nrg1 HET).
Response of esophageal cancer cells to epigenetic inhibitors is mediated via altered thioredoxin activity.
New
Lassmann et al., Freiburg, Germany. In Lab Invest, Jan 2016
Also in vitro, nuclear Trx was only detectable in non-neoplastic Het-1A cells, but not in OE21/ESCC or OE33/EAC cell lines.
Genetic Association Between Angiotensinogen Polymorphisms and Lung Cancer Risk.
Review
New
Cao et al., Beijing, China. In Medicine (baltimore), Sep 2015
P values for heterogeneity test (Q-test) [P(Het)] = 0.382).
Biomarkers for efficacy of adjuvant chemotherapy following complete resection in NSCLC stages I-IIIA.
Review
New
Sørensen et al., Copenhagen, Denmark. In Eur Respir Rev, Jun 2015
A statistically significant prognostic impact was reported for: iNTR, TUBB3, RRM1, ERCC1, BRCA1, p53, MRP2, MSH2, TS, mucin, BAG-1, pERK1/2, pAkt-1, microRNA, TopIIA, 15-gene profile, 92-gene profile, 31-gene profile and 14-gene profile.
As a toxin dies a prion comes to life: A tentative natural history of the [Het-s] prion.
Review
Saupe et al., Bordeaux, France. In Prion, 2014
Herein, we recall the relation of the [Het-s] prion to the signal transduction pathway controlled by the NWD2 Nod-like receptor, leading to activation of the HET-S pore-forming cell death execution protein.
Traditional Japanese herbal medicines for treatment of odontopathy.
Review
Yamaguchi, Kagoshima, Japan. In Front Pharmacol, 2014
This review explains in more details Hozai such as Hochuekkito (HET), Juzendaihoto, and Ninjinyoeito (NYT) that are frequently used to improve both immunosuppression and deficiencies of Ki, Ketsu, and Sui in oral cancer patients.
Carboxylate-assisted ruthenium-catalyzed alkyne annulations by C-H/Het-H bond functionalizations.
Impact
Ackermann, Göttingen, Germany. In Acc Chem Res, 2014
To improve the atom- and step-economy of organic syntheses, researchers would like to capitalize upon the chemistry of otherwise inert carbon-hydrogen (C-H) bonds.
Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice.
Review
Clark et al., Fort Worth, United States. In Exp Eye Res, 2013
Ad5.hTGFβ2(226/228) (2.5 × 10(7) pfu) was injected intravitreally into one eye of homozygous (WT), heterozygous (HET), and homozygous (KO) 129-Smad3(tm1Par)/J mice (n = 9-10 mice/group), with the uninjected contralateral eye serving as the control.
Molecular structures of amyloid and prion fibrils: consensus versus controversy.
Review
Impact
Wickner et al., Bethesda, United States. In Acc Chem Res, 2013
The fungal HET-s prion protein has been shown to contain a β-helical structure.
Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα.
GeneRIF
Kawata et al., Kyoto, Japan. In J Cell Biochem, 2012
Results indicate that SAFB1 and SAFB2 are crucial repressors for ERalpha dynamics in association with the nuclear matrix and that their synergistic regulation of ERalpha mobility is sufficient for inhibiting ERalpha function.
Correlation between BRAF mutation and promoter methylation of TIMP3, RARβ2 and RASSF1A in thyroid cancer.
GeneRIF
Hoque et al., Baltimore, United States. In Epigenetics, 2012
In papillary thyroid cancer, significant correlations between the methylation status of the RARbeta2 gene and the V600E BRAF mutation were found.
Epstein-Barr Virus latent membrane protein 1 overcomes all-trans retinoic acid-induced apoptosis by inhibiting retinoic acid receptor-β₂ expression.
GeneRIF
Jang et al., Pusan, South Korea. In Biochem Biophys Res Commun, 2012
LMP1 overcomes all-trans retinoic acid-induced apoptosis by repressing RAR-b2 expression via DNA methylation.
[Correlation between RARbeta gene promoter methylation and P53 gene mutations in non-small cell lung cancer].
GeneRIF
Sun et al., Hangzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
RARbeta gene promoter methylation and P53 mutation were detected in 58.1% and 36.4% of tumors, respectively.
Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.
GeneRIF
Klinge et al., Louisville, United States. In Plos One, 2011
nucleolin plays a coregulatory role in transcriptional regulation of the tumor suppressor RARB2 by COUP-TFII
Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core.
Impact
Meier et al., Zürich, Switzerland. In Science, 2008
We present a structural model based on solid-state nuclear magnetic resonance restraints for amyloid fibrils from the prion-forming domain (residues 218 to 289) of the HET-s protein from the filamentous fungus Podospora anserina.
International Union of Pharmacology. LX. Retinoic acid receptors.
Review
Impact
Gronemeyer et al., Strasbourg, France. In Pharmacol Rev, 2006
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARalpha, RARbeta, and RARgamma), members of the nuclear hormone receptor superfamily.
Correlation of structural elements and infectivity of the HET-s prion.
Impact
Riek et al., Los Angeles, United States. In Nature, 2005
HET-s, the prion protein of P. anserina, contains a carboxy-terminal prion domain comprising residues 218-289.
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