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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Retinoic acid receptor, alpha

RAR, RARalpha, RARA
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: ACID, PML, CAN, V1a, HAD
Papers using RAR antibodies
A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein
Supplier
Le Beau Michelle M. et al., In Oncogene, 2002
... Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute ...
Activated Polymorphonuclear Leukocytes Rapidly Synthesize Retinoic Acid Receptor-α
Supplier
Zimmerman Guy A. et al., In The Journal of Experimental Medicine, 1993
... PAF, AM-580 (an RAR-α–specific agonist), and the anti–human RAR-α monoclonal antibody were purchased from BioMol.
Papers on RAR
Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple negative breast cancer.
New
Sukumar et al., Hopkins, United States. In Cancer Res, Feb 2016
UNASSIGNED: Efforts to induce the differentiation of cancer stem cells through treatment with all-trans retinoic acid (ATRA) have yielded limited success, partially due to the epigenetic silencing of the retinoic acid receptor (RAR)-β.
The leukemic oncoprotein NPM1-RARA inhibits TP53 activity.
New
Redner et al., Pittsburgh, United States. In Leuk Lymphoma, Feb 2016
UNASSIGNED: The variant acute promyelocytic leukemia (APL) translocation t(5;17)(q35;q21) fuses the N-terminus of nucleophosmin (NPM1) to the retinoic acid receptor alpha (RARA).
Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.
New
Impact
So et al., Hong Kong, Hong Kong. In Nat Med, Dec 2015
Here we demonstrate that AML driven by repressive transcription factors, including AML1-ETO (encoded by the fusion oncogene RUNX1-RUNX1T1) and PML-RARα fusion oncoproteins (encoded by PML-RARA) are extremely sensitive to poly (ADP-ribose) polymerase (PARP) inhibition, in part owing to their suppressed expression of key homologous recombination (HR)-associated genes and their compromised DNA-damage response (DDR).
Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium.
New
Hizawa et al., Tsukuba, Japan. In Plos One, Dec 2015
Transcription factor RAR-related orphan receptor gamma t (RORγt) is known as the master regulator for Th17 cell development.
[Significance of PLSCR1 in Matrine Induced Differentiation of ATRA Resistant APL Cells].
New
Zhou et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
CONCLUSION: MAT combined ATRA could significantly induce the differentiation of NB4-R1 cells, and inhibit the expression of PML/RARalpha fusion gene/protein, which might be associated with up-regulating PLSCR1 expression.
Genomic landscapes of breast fibroepithelial tumors.
New
Impact
Teh et al., Singapore, Singapore. In Nat Genet, Nov 2015
First, we frequently observed MED12 and RARA mutations in both fibroadenomas and phyllodes tumors, emphasizing the importance of these mutations in fibroepithelial tumorigenesis.
Role of retinoids in the prevention and treatment of colorectal cancer.
Review
New
Lane et al., San Marcos, United States. In World J Gastrointest Oncol, Nov 2015
Retinoids affect these pathways by various mechanisms, many involving retinoic acid receptors (RAR).
Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice.
Review
New
Romagnani et al., Genova, Italy. In Eur J Immunol, Aug 2015
ILC3s express the retinoic acid receptor (RAR) related orphan receptor RORγt and the signature cytokines IL-22 and IL-17.
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.
New
Impact
Lu et al., Boston, United States. In Nat Med, May 2015
ATRA-induced Pin1 ablation degrades the protein encoded by the fusion oncogene PML-RARA and treats APL in APL cell and animal models as well as in human patients.
Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis.
Review
Zhang et al., Changchun, China. In Int J Ophthalmol, 2014
Retinoic acid receptor α (RAR α), retinoic acid receptor γ (RAR γ), and retinoid X receptor α (RXR α) are expressed in the cornea and immune cells.
Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.
Review
Chen et al., Wuhan, China. In Int J Mol Sci, 2014
RAR/RXR heterodimers or RXR/RXR homodimers bind to RA response element in the promoters of RA target genes and regulate their expressions upon ligand binding.
Inhibition by a retinoic acid receptor γ agonist of extracellular matrix remodeling mediated by human Tenon fibroblasts.
Sonoda et al., Ube, Japan. In Mol Vis, 2014
The effects of the retinoic acid receptor (RAR) γ agonist R667 on the contractility of human Tenon fibroblasts (HTFs) cultured in a three-dimensional collagen gel as well as on intraocular pressure (IOP) in a rat model of glaucoma filtration surgery were investigated.
Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure.
Impact
de Thé et al., Paris, France. In Nat Med, 2014
Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)-retinoic acid receptor-α (PML-RARA) fusion protein, which interferes with nuclear receptor signaling and PML nuclear body (NB) assembly.
Molecular Mechanisms of Retinoid Receptors in Diabetes-Induced Cardiac Remodeling.
Review
Baker et al., Temple, United States. In J Clin Med, 2013
Retinoic acid, the active metabolite of vitamin A, is involved in a wide range of biological processes, through binding and activation of nuclear receptors: retinoic acid receptors (RAR) and retinoid X receptors (RXR).
Vitamin a metabolism, action, and role in skeletal homeostasis.
Review
Impact
Lerner et al., Umeå, Sweden. In Endocr Rev, 2013
RAR-retinoid X receptor heterodimers function as transcription factors, binding RAR-responsive elements in promoters of different genes.
A retinoic acid receptor RARα pool present in membrane lipid rafts forms complexes with G protein αQ to activate p38MAPK.
GeneRIF
Rochette-Egly et al., Illkirch-Graffenstaden, France. In Oncogene, 2012
a novel paradigm in which a fraction of the cellular RARalpha pool is present in membrane lipid rafts, where it forms complexes with G protein alpha Q (Galphaq) in response to RA
PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells.
GeneRIF
Tschan et al., Bern, Switzerland. In Blood, 2012
HK3 is: (1) directly activated by PU.1, (2) repressed by PML-RARA, and (3) functionally involved in neutrophil differentiation and cell viability of acute promyelocytic leukemia cells.
TRIM32 promotes retinoic acid receptor α-mediated differentiation in human promyelogenous leukemic cell line HL60.
GeneRIF
Hatakeyama et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
These findings suggest that TRIM32 functions as one of the coactivators for RARalpha-mediated transcription in acute promyelogenous leukemia cells.
Infantile acute promyelocytic leukemia without an RARα rearrangement.
GeneRIF
Tsutsumi et al., Sapporo, Japan. In Pediatr Int, 2011
APL lacking an RARalpha rearrangement may possess an alternative mechanism mediating the differentiation block that causes APL.
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