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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transcriptional regulating factor 1

This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CsA, mTOR, HAD, CD4
Papers using RAPA antibodies
Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability
Dello Russo Cinzia et al., In Journal of Neuroinflammation, 1997
... Rapamycin (RAPA) was purchased from Tocris Bioscience (Bristol, UK) ...
Papers on RAPA
Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice.
Hellerstein et al., Berkeley, United States. In Aging Cell, Feb 2016
To determine whether changes in these processes may contribute to or predict delayed aging in mammals, we measured cell proliferation rates and the synthesis and replacement rates (RRs) of over a hundred hepatic proteins in vivo in three different mouse models of extended maximum lifespan (maxLS): Snell Dwarf, calorie-restricted (CR), and rapamycin (Rapa)-treated mice.
IL-35 inhibits acute graft-versus-host disease in a mouse model.
Huang et al., Beijing, China. In Int Immunopharmacol, Dec 2015
We observed that treatment with IL-35 and RAPA could reduce the incidence of aGVHD.
Preparation of Porous Core-Shell Poly L-Lactic Acid/Polyethylene Glycol Superfine Fibres Containing Drug.
Ji et al., In J Nanosci Nanotechnol, Dec 2015
In this paper, poly L-lactic acid (PLLA) blended with polyethylene glycol (PEG) was dissolved in methylene dichloride solution as the shell solution, and rapamycin (RAPA), was encapsulated inside the core of PLLA micro/nano fibres as a model drug.
Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo.
Ray et al., Columbia, United States. In Apoptosis, Dec 2015
Further, combination of LUT and SIL inhibited rapamycin (RAPA)-induced autophagy, a survival mechanism, with suppression of PKCα and promotion of apoptosis through down regulation of iNOS and significant increase in expression of the tumor suppressor miR-7-1-3p in glioblastoma cells.
Autophagy activation attenuates angiotensin II-induced cardiac fibrosis.
Jiang et al., Guangzhou, China. In Arch Biochem Biophys, Dec 2015
In rat CFs, co-treated with rapamycin (Rapa), an autophagy inducer, Ang II-induced the upregulation of type I collagen (Col-I), fibronectin (FN) was decreased.
mTOR in Brain Physiology and Pathologies.
Marin et al., Montpellier, France. In Physiol Rev, Oct 2015
TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an effort to understand the mechanisms of action of the immunosuppressant drug rapamycin extracted from a bacterium of the Easter Island (Rapa Nui) soil.
Phosphatidylethanolamine-binding protein 4 promotes lung cancer cells proliferation and invasion via PI3K/Akt/mTOR axis.
Mi et al., Jiangyin, China. In J Thorac Dis, Oct 2015
Furthermore, the effect of mTOR inhibitor rapamycin (RAPA) on the expressions of PI3K/Akt/mTOR pathway components under the effect of PEBP4 was determined using Western blotting, and the effects of RAPA on the cell viability, proliferation, and migration capabilities under the overexpression of PEBP4 were determined using MTT method, flow cytometry, and Transwell migration assay.
[Rapamycin-conditioned dendritic cells induced immune tolerance through the regulation of Treg/Th17 cells in mice].
Zhang et al., Beijing, China. In Zhonghua Yi Xue Za Zhi, Sep 2015
OBJECTIVE: To investigate the effect of tolerogenic dendritic cells (Tol-DC) generated by Rapamycin (Rapa) on the differentiation of Treg/Th17 cells and explore the possible mechanism of tolerance induction.
Evolving perspectives of mTOR complexes in immunity and transplantation.
Thomson et al., Pittsburgh, United States. In Am J Transplant, Apr 2015
Since the discovery of Rapamycin (RAPA) and its immunosuppressive properties, enormous progress has been made in characterizing the mechanistic target of rapamycin (mTOR).
The Impact of Paeoniflorin on α-Synuclein Degradation Pathway.
Li et al., Xinpu, China. In Evid Based Complement Alternat Med, 2014
Cell viability significantly improved after 24 h exposure to RAPA and PF in the MPP+ group (all P < 0.01).
Rapamycin Protects from Type-I Peritoneal Membrane Failure Inhibiting the Angiogenesis, Lymphangiogenesis, and Endo-MT.
Liappas et al., Madrid, Spain. In Biomed Res Int, 2014
We demonstrate that mice undergoing a combined PD and Rapamycin treatment (PDF + Rapa group) presented a reduced PM thickness and lower number of submesothelial blood and lymphatic vessels, as well as decreased MMT and Endo-MT, comparing with their counterparts exposed to PD alone (PDF group).
The effects of rapamycin on regulatory T cells: its potential time-dependent role in inducing transplant tolerance.
Chen et al., Chengdu, China. In Immunol Lett, 2014
The immunosuppressive drug rapamycin (RAPA) has been used clinically to prevent graft rejection since 1999 because of its suppressive effects on T cell activation and proliferation.
Structure and function of RapA: a bacterial Swi2/Snf2 protein required for RNA polymerase recycling in transcription.
Ji et al., Frederick, United States. In Biochim Biophys Acta, 2011
A bacterial Swi2/Snf2 protein named RapA from Escherichia coli is a unique addition to these studies.
The effects of immunosuppressive drugs on CD4(+) CD25(+) regulatory T cells: a systematic review of clinical and basic research.
Li et al., Chengdu, China. In J Evid Based Med, 2010
The immunosuppressive drugs studied were calcineurin inhibitors (CNIs), Rapa, anti-metabolism drugs, IL-2 receptor-blocking antibodies, T-cell depleting antibodies, and co-stimulation blockade antibodies.
TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone.
Staels et al., Lille, France. In Mol Cell Biol, 2006
identify TReP-132 as a coactivator of progesterone receptor mediating the growth-inhibitory and differentiation effects of progesterone on breast cancer cells
TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1.
Hum et al., Québec, Canada. In Mol Cell Biol, 2005
TReP-132 is a basal cell cycle regulatory protein interacting with Sp1 to activate the p21 and p27 gene promoters.
The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells.
Hum et al., Québec, Canada. In J Mol Endocrinol, 2004
TReP-132 is a trans-acting factor of genes involved in adrenal glucocorticoid, C(19) steroid and estrogen production.
Cloning of murine TReP-132, a novel transcription factor expressed in brain regions involved in behavioral and psychiatric disorders.
Rivest et al., Canada. In Mol Psychiatry, 2003
cloning and characterization; expression of both mTReP-132 and P450scc provides anatomical evidence that mTReP-132 may regulate this key steroidogenic enzyme within specific regions of the brain involved in behavioral and psychiatric disorders
Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression.
Hum et al., Québec, Canada. In Endocr Res, 2002
TReP-132 interacts with steroidogenic factor-1 (SF-1) through specific domains; and along with the interaction with CBP/p300 these factors are postulated to form a complex to regulate expression of the P450scc gene.
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor.
Geissler et al., Regensburg, Germany. In Nat Med, 2002
In the present study we show that the new immunosuppressive drug rapamycin (RAPA) may reduce the risk of cancer development while simultaneously providing effective immunosuppression.
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