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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ubiquitin interaction motif containing 1

RAP80, UIMC1
Top mentioned proteins: Iris, Ubiquitin, RNF8, CAN, CCDC98
Papers on RAP80
RAP80 regulates epithelial mesenchymal transition related with metastasis and malignancy of cancer.
New
Lee et al., Taejŏn, South Korea. In Cancer Sci, Feb 2016
Here, we showed that EMT is induced by the down-regulation of RAP80, a well-known regulator for DNA damage response.
A novelly synthesized phenanthroline derivative is a promising DNA-damaging anticancer agent inhibiting G1/S checkpoint transition and inducing cell apoptosis in cancer cells.
New
Yu et al., Shanghai, China. In Cancer Chemother Pharmacol, Jan 2016
Moreover, it is a DNA-damaging agent, interrupting the cell cycle G1/S checkpoint transition and inducing cell apoptosis by not only activating ATM/CHK1 signaling pathway, but also targeting CHK1 to reduce the expression of RAP80 and PARP-1 to compromise the DNA damage repair in tumor cells.
Molecular Basis for Phosphorylation Dependent SUMO Recognition by the DNA Repair Protein RAP80.
New
Spyracopoulos et al., Canada. In J Biol Chem, Jan 2016
RAP80 is a component of the BRCA1 A complex, and plays a key role in the recruitment process through the binding of K63-linked polyUb chains by tandem Ub interacting motifs (UIM).
ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screen.
New
Lavin et al., Australia. In Mol Cell Proteomics, Jan 2016
Two of these 11 were previously described as ATM substrates (HMGA1 and UIMCI/RAP80), another five were identified in a whole cell extract phosphoproteomic screens and the remaining four proteins had not been identified previously in DNA damage response screens.
TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.
New
Kim et al., Suwŏn, South Korea. In Nat Commun, Dec 2015
RAP80 localizes to sites of DNA insults to enhance the DNA-damage responses.
PALB2: the hub of a network of tumor suppressors involved in DNA damage responses.
Review
Andreassen et al., Cincinnati, United States. In Biochim Biophys Acta, 2014
The recruitment of PALB2 to DNA double-strand breaks at the head of this network is via a ubiquitin-dependent signaling pathway that involves the RAP80, Abraxas and BRCA1 tumor suppressors.
DNA DSB repair pathway choice: an orchestrated handover mechanism.
Review
Jeggo et al., Brighton, United Kingdom. In Br J Radiol, 2014
K63-linked ubiquitin chains, which also form at IRIF, are also repositioned as well as receptor-associated protein 80 (RAP80), a ubiquitin binding protein.
Predictive models for customizing chemotherapy in advanced non-small cell lung cancer (NSCLC).
Review
Bonanno, Padova, Italy. In Transl Lung Cancer Res, 2013
In addition, the mRNA levels of expression of RAP80, encoding for a protein cooperating with BRCA1 in homologous recombination (HR), have demonstrated to further sub-classify low BRCA1 NSCLC tumors, improving the predictive model.
Customized chemotherapy in metastatic non-small cell lung cancer (NSCLC).
Review
Rosell et al., Nanjing, China. In Transl Lung Cancer Res, 2013
In one attempt to demonstrate the role of tailoring chemotherapy, the Spanish Lung Cancer Group (SLCG) phase II customized chemotherapy trial (NCT00883480) showed that RAP80, a component of the BRCA1-A complex, influenced outcome in patients with low BRCA1 expression treated with cisplatin/gemcitabine, and in patients with intermediate/high BRCA1 levels receiving cisplatin/docetaxel or docetaxel alone.
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.
GeneRIF
Durocher et al., Toronto, Canada. In Mol Cell, 2012
We show that RNF168, its paralog RNF169, RAD18, and the BRCA1-interacting RAP80 protein accumulate at DNA double strand break sites through the use of bipartite modules composed of ubiquitin binding domains.
Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates.
GeneRIF
Wang et al., Houston, United States. In J Biol Chem, 2012
a model in which SUMO and Ub modification is coordinated to recruit Rap80 and BRCA1 to DNA damage sites.
RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo.
GeneRIF
Yu et al., Ann Arbor, United States. In J Biol Chem, 2012
Mechanistically, loss of RAP80 suppresses recruitment of the BRCA1-A complex to DNA damage sites and abrogates the DNA damage repair process at DNA damage sites.
Degradation of human RAP80 is cell cycle regulated by Cdc20 and Cdh1 ubiquitin ligases.
GeneRIF
Kim et al., Suwŏn, South Korea. In Mol Cancer Res, 2012
APC/C(Cdc20) or APC/C(Cdh1) complexes regulate RAP80 stability during mitosis to the G(1) phase, and these events are critical for a novel function of RAP80 in mitotic progression.
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Impact
Lunetta et al., Rotterdam, Netherlands. In Nat Genet, 2012
Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)).
Recruitment of proteins to DNA double-strand breaks: MDC1 directly recruits RAP80.
GeneRIF
Goldberg et al., Jerusalem, Israel. In Cell Cycle, 2011
MDC1 is required for the recruitment of RAP80 to DNA double-strand breaks.
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.
Impact
Mailand et al., Copenhagen, Denmark. In Nat Cell Biol, 2010
Consequently, knockdown of HERC2 abrogates ubiquitin-dependent retention of repair factors such as 53BP1, RAP80 and BRCA1.
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
Impact
Chasman et al., Boston, United States. In Nat Genet, 2009
(in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L).
RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.
Review
GeneRIF
Jetten et al., United States. In Cancer Lett, 2008
Depletion of RAP80 or RNF8 impairs the translocation of BRCA1 to DNA damage sites and results in defective cell cycle checkpoint control and DSB repair
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.
Impact
GeneRIF
Greenberg et al., Boston, United States. In Science, 2007
data support a model wherein ubiquitin chains at DNA damage sites are used as a targeting mechanism by specific BRCA1 complexes; RAP80 may represent a new class of DNA repair proteins that uses tandem UIM domains as part of its recruitment to DSBs
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.
Impact
GeneRIF
Yu et al., New Haven, United States. In Science, 2007
identification of receptor-associated protein 80 (RAP80) as a BRCA1-interacting protein in humans
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