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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RAP2A, member of RAS oncogene family

Rap2, Rap2A
human homolog is a GTPase and member of the RAS oncogene family [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rap1, RAP, ACID, CAN, HAD
Papers using Rap2 antibodies
Signaling endosome hypothesis: A cellular mechanism for long distance communication.
Supplier
Linden Rafael, In PLoS ONE, 2003
... (Millipore, Billerica, MA), anti-rabbit IgG HRP and anti-mouse IgG HRP (GE Healthcare; Piscataway, NJ), and anti-Rap2 (BD Biosciences, San Jose, CA) ...
Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
Supplier
Johnson Keith R. et al., In The Journal of Cell Biology, 2002
... mAb, anti-Pyk2 mouse mAb, anti-phosphotyrosine (PY20) mouse mAb, anti-p130CAS mouse mAb, anti-JNK1 mouse mAb, and anti-Rap2 mouse mAb were obtained from BD Biosciences.
Papers on Rap2
E-type cyclins modulate telomere integrity in mammalian male meiosis.
New
Wolgemuth et al., New York City, United States. In Chromosoma, Jan 2016
We show that their telomeres exhibited an aberrant DNA damage repair response during pachynema and that the shelterin complex proteins TRF2 and RAP2 were significantly decreased in the proximal telomeres.
Arabidopsis NRT1.5 mediates the suppression of nitrate starvation-induced leaf senescence by modulating foliar potassium level.
New
Gong et al., Shanghai, China. In Mol Plant, Jan 2016
Nitrate starvation also down-regulated the expression of HAK5, RAP2.11 and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5.
Redundant ERF-VII transcription factors bind an evolutionarily-conserved cis-motif to regulate hypoxia-responsive gene expression in Arabidopsis.
New
Mustroph et al., Riverside, United States. In Plant Cell, Jan 2016
Here, by use of single- and double-null mutants, the constitutively synthesized ERF-VIIs RELATED TO APETELA2 2 (RAP2.2) and RAP2.12 are shown to act redundantly as principle activators of hypoxia-responsive genes; constitutively expressed RAP2.3 contributes to this redundancy, whereas the hypoxia-induced HYPOXIA REPSONSIVE ERF1 (HRE1) and HRE2 play minor roles.
A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of JA in Arabidopsis.
New
Zhou et al., Shanghai, China. In J Integr Plant Biol, Oct 2015
To identify components involved in Arabidopsis wound and JA signaling pathway, we screened for mutants with abnormal expression of a luciferase reporter which is under the control of a wound-responsive promoter of an ethylene response factor (ERF) transcription factor gene, RAP2.6 (Related to APetala 2.6).
RAP-PCR fingerprinting reveals time-dependent expression of development-related genes following differentiation process of Bacillus thuringiensis.
New
Guan et al., Fuzhou, China. In Can J Microbiol, Sep 2015
RAP2 was homologous to a ClpX protease and an ATP-dependent protease La (LonB), which likely acted as virulence factors.
An immunomics approach for the analysis of natural antibody responses to Plasmodium vivax infection.
New
Hu et al., Shanghai, China. In Mol Biosyst, Aug 2015
Pv34, SUB1, RAP2 and MSP4).
Constitutively expressed ERF-VII transcription factors redundantly activate the core anaerobic response in Arabidopsis thaliana.
New
Licausi et al., Pisa, Italy. In Plant Sci, Jul 2015
When the activity of each transcription factor was tested on a set of hypoxia-responsive promoters, RAP2.2,
The structure and conformational switching of Rap1B.
New
Unzai et al., Yokohama, Japan. In Biochem Biophys Res Commun, Jul 2015
Unlike other Ras family proteins such as H-Ras and Rap2A, Rap1B crystallizes in an intermediate state when bound to a non-hydrolyzable GTP analog.
Molecular and physiological mechanisms regulating tissue reunion in incised plant tissues.
Review
New
Satoh et al., Utsunomiya, Japan. In J Plant Res, May 2015
Ethylene and jasmonic acid modulate the expression of ANAC071 and RAP2.6L, respectively, and auxin signaling via ARF6/8 is essential for the expression of these transcription factors.
Rap2A links intestinal cell polarity to brush border formation.
Impact
GeneRIF
Bos et al., Utrecht, Netherlands. In Nat Cell Biol, 2012
Rap2A and TNIK control brush border formation by apical recruitment of MST4 and the subsequent phosphorylation of Ezrin
Making sense of low oxygen sensing.
Review
van Dongen et al., Riverside, United States. In Trends Plant Sci, 2012
Oxygen-dependent sequestration at the plasma membrane maintains at least one of these proteins, RAP2.12, under normoxia.
Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization.
Impact
van Dongen et al., Potsdam, Germany. In Nature, 2011
We identified a conserved amino-terminal amino acid sequence of the ethylene response factor (ERF)-transcription factor RAP2.12 to be dedicated to an oxygen-dependent sequence of post-translational modifications, which ultimately lead to degradation of RAP2.12 under aerobic conditions.
CBF-dependent signaling pathway: a key responder to low temperature stress in plants.
Review
Lin et al., Shanghai, China. In Crit Rev Biotechnol, 2011
RAP2.1 and RAP2.6 are the downstream regulators under CBFs.
RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange.
GeneRIF
Tazebay et al., Ankara, Turkey. In Febs J, 2009
analyzed residues that allow RasGEF1 proteins to discriminate between Rap1 and Rap2, and identified Phe39 in the switch I region of Rap2 as a specificity residue.
Beta2 integrins target Rap GTPases to the plasma membrane by means of degranulation.
GeneRIF
Andersson et al., Belfast, United Kingdom. In Biochem Biophys Res Commun, 2008
The beta2 integrin-dependent exocytosis of specific and gelatinase B-containing granules is responsible for the translocation of Rap1 and Rap2 to the plasma membrane in human neutrophils.
Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction.
GeneRIF
Sheng et al., Cambridge, United States. In J Neurosci, 2008
Study presents evidence of fewer spines and reduced signaling in Rap2 transgenic mice, consistent with an inhibitory role for Rap2 at synapses.
Redox signal integration: from stimulus to networks and genes.
Review
Dietz, Bielefeld, Germany. In Physiol Plant, 2008
Gene activity regulation by transcription factors such as TGA, Athb-9 and RAP2 directly or indirectly is controlled by the redox state.
Rap2 regulates androgen sensitivity in human prostate cancer cells.
GeneRIF
Theodorescu et al., Charlottesville, United States. In Prostate, 2007
Rap2 is involved in androgen-mediated transcriptional and growth responses of human prostate cancer cells.
Ras and relatives--job sharing and networking keep an old family together.
Review
Schrader et al., Vancouver, Canada. In Exp Hematol, 2002
Besides the four p21 Ras proteins, the Ras subfamily of the Ras superfamily includes R-Ras, TC21 (R-Ras2), M-Ras (R-Ras3), Rap1A, Rap1B, Rap2A, Rap2B, RalA, and RalB.
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